Abstract: The present disclosure provides, inter alia, methods for treating infectious diseases, e.g., a microsporidia infection caused by Nosema ceranae, in a subject such as, e.g., a honeybee, using proteasome inhibitors including Ixazomib. Methods for monitoring the progress of a microsporidia infection in a subject, and methods for measuring the intensity of a microsporidia infection in a subject, are also provided.

Abstract: There is provided a method of, computer programs for and apparatus for providing and accessing digital content such as a news item. A news provider generates a news item, creates a digitally signed version of the news item and packages them together with a digital certificate issued by a certificate authority containing the public key required to decrypt the digitally signed version. The package is posted to a server and is transmitted, or made available or transmission, over a public data network together with a computer program for verifying the news item. A receiving party receives, over the public data network, the package at a client device and is provided with means for launching, and if necessary first downloading, the verifying program. The verifying program uses the public key contained in the certificate to verify the digitally signed news item.

Abstract: A process for preparing benzimidazole thiophenes including 5-{6-[(4-methylpiperazin-1-yl)methyl]-1H-benzimidazol-1-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide.

Abstract: Methods, apparatus, and systems for deploying and retrieving sensors downhole are provided. The apparatus can include an outer tubular member disposed about one or more inner tubular members coupled to a fluid directional controller. The fluid directional controller may include a housing separating an interior cavity from an external environment of the wellbore. One end of the outer tubular member and at least one end of an inner tubular member may communicate with the interior cavity. The housing may also include a passageway configured to provide fluid communication between the interior cavity and the external environment. A flow control device may selectively facilitate fluid flow through the passageway. Accordingly, a sensor located in the interior cavity may be selectively exposed to fluid from the external environment. Sensors may be deployed by flowing fluid through a particular tubular member in one direction and retrieved by flowing fluid in another direction.

Abstract: A process for preparing benzimidazole thiophenes including 5-{6-[(4-methylpiperazin-1-yl)methyl]-1H-benzimidazol-1-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide.

Abstract: Financial news distribution apparatus comprising: a first terminal (10) comprising means (14, 17) for displaying a selected one of a plurality of data entry screens (1000) associated with news items of different types, each said data entry screen comprising: a plurality of data entry fields (1004) for entry of respective data items of a new said news item, and respective data item label text fields (1002) each containing text describing the corresponding data entry field in a source language, selection means (12) for selecting at least one of a plurality of target languages; translation means (50) for translating the source language text of said data item label text fields (1002) into corresponding text in said at least one target language; means (12) for inputting data specifying a type of news item and a subject of a new news item; a computer (30) remote to said first terminal (10), said computer (40) being arranged to read a store (40) containing a database of previous news items, accessible by type and su

Abstract: A method of preparing a compound of formula (I), and pharmaceutically acceptable salts and solvates thereof.

Abstract: The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5? monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.

Abstract: The invention is a sealing system, such as a packer, that is used in a wellbore to seal against an exterior surface, such as a casing or open wellbore. The sealing system includes a swellable material that swells from an unexpanded state to an expanded state thereby creating a seal when the swellable material comes into contact with a triggering fluid.

Abstract: A method of preparing a compound of formula (I), and pharmaceutically acceptable salts and solvates thereof. Polymorphs of this compound and their use as PPAR ligands are also disclosed.

Abstract: A process for the preparation of a compound of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR4R5; R1 and R2 are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5, (CH2)nSC1-6alkyl or C(O)NR4R5; with the proviso that when R0 is at the 4-position and is halogen, at least one of R1 and R2 is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR4R5 or (CH2)nSC1-6alkyl, C(O)NR4R5; R3 is C1-6alkyl or NH2; R4 and R5 are independently selected from H, or C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; and

Abstract: There is provided a method of, computer programs for and apparatus for providing and accessing digital content such as a news item. A news provider generates a news item, creates a digitally signed version of the news item and packages them together with a digital certificate issued by a certificate authority containing the public key required to decrypt the digitally signed version. The package is posted to a server and is transmitted, or made available or transmission, over a public data network together with a computer program for verifying the news item. A receiving party receives, over the public data network, the package at a client device and is provided with means for launching, and if necessary first downloading, the verifying program. The verifying program uses the public key contained in the certificate to verify the digitally signed news item.

Abstract: Financial news distribution apparatus comprising: a first terminal (10) comprising means (14, 17) for displaying a selected one of a plurality of data entry screens (1000) associated with news items of different types, each said data entry screen comprising: a plurality of data entry fields (1004) for entry of respective data items of a new said news item, and respective data item label text fields (1002) each containing text describing the corresponding data entry field in a source language, selection means (12) for selecting at least one of a plurality of target languages; translation means (50) for translating the source language text of said data item label text fields (1002) into corresponding text in said at least one target language; means (12) for inputting data specifying a type of news item and a subject of a new news item; a computer (30) remote to said first terminal (10), said computer (40) being arranged to read a store (40) containing a database of previous news items, accessible by type and su

Abstract: 1

Abstract: The invention relates to a diastereoselective process for the preparation of compounds of formula (1), wherein W is S, S═O, SO2 or O; X is S, S═O, SO2 or O; R1 is hydrogen or acyl, and R2 is a purine or pyrimidine base or an analogue or derivative thereof.

Abstract: The invention relates to a diastereoselective process for the preparation of compounds of formula (I), wherein W is S, S.dbd.O, SO.sub.2 or O; X is S, S.dbd.O, SO.sub.2 or O; R.sub.1 is hydrogen or acyl, and R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof.