Patents by Inventor Jonathan William Larson
Jonathan William Larson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260117283Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: October 20, 2025Publication date: April 30, 2026Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20250362211Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.Type: ApplicationFiled: June 6, 2025Publication date: November 27, 2025Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Link, Mark Weary
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Patent number: 12454718Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: GrantFiled: January 13, 2022Date of Patent: October 28, 2025Assignee: Bio-Rad Laboratories, Inc.Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Patent number: 12378598Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: GrantFiled: September 12, 2023Date of Patent: August 5, 2025Assignee: Bio-Rad Laboratories, Inc.Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Patent number: 12351860Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: GrantFiled: November 22, 2022Date of Patent: July 8, 2025Assignee: Bio-Rad Laboratories, Inc.Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Patent number: 12352673Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.Type: GrantFiled: January 24, 2022Date of Patent: July 8, 2025Assignee: Bio-Rad Laboratories, Inc.Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Link, Mark Weary
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Patent number: 12241116Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: GrantFiled: December 12, 2023Date of Patent: March 4, 2025Assignee: BIO-RAD LABORATORIES, INC.Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Patent number: 12031175Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: GrantFiled: November 20, 2023Date of Patent: July 9, 2024Assignee: Bio-Rad Laboratories, Inc.Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20240132939Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: December 12, 2023Publication date: April 25, 2024Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20240093271Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: November 20, 2023Publication date: March 21, 2024Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20240002910Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: September 12, 2023Publication date: January 4, 2024Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20230086845Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: November 22, 2022Publication date: March 23, 2023Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20220213530Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: ApplicationFiled: January 13, 2022Publication date: July 7, 2022Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Publication number: 20220143617Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.Type: ApplicationFiled: January 24, 2022Publication date: May 12, 2022Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Link, Mark Weary
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Patent number: 11268887Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.Type: GrantFiled: January 2, 2020Date of Patent: March 8, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Roy Link, Mark Weary
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Patent number: 11254968Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.Type: GrantFiled: August 28, 2017Date of Patent: February 22, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Jonathan William Larson, Qun Zhong, Darren Roy Link
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Patent number: 11077415Abstract: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.Type: GrantFiled: November 5, 2018Date of Patent: August 3, 2021Assignee: Bio-Rad Laboratories, Inc.Inventors: Yevgeny Yurkovetsky, Darren Roy Link, Jonathan William Larson
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Publication number: 20200225129Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.Type: ApplicationFiled: January 2, 2020Publication date: July 16, 2020Inventors: Benjamin Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Roy Link, Mark Weary
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Patent number: 10527529Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.Type: GrantFiled: August 10, 2017Date of Patent: January 7, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Benjamin J. Miller, Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren Roy Link, Mark Weary
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Publication number: 20190134581Abstract: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.Type: ApplicationFiled: November 5, 2018Publication date: May 9, 2019Inventors: Yevgeny Yurkovetsky, Darren Roy Link, Jonathan William Larson
