Patents by Inventor Jonathan William Medley

Jonathan William Medley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRAS G12D MODULATING COMPOUNDS
    Publication number: 20250136621
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: December 23, 2024
    Publication date: May 1, 2025
    Inventors: Chaodi Dai, Juan A. Guerrero, Darryl Kato, Scott E. Lazerwith, Jonathan William Medley, Thomas C.J. Mies, Hyung-Jung Pyun, Hayato Shiotsu, Maoqun Tian, William J. Watkins, Jennifer R. Zhang
  • PD-1/PD-L1 inhibitors
    Patent number: 12269812
    Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: April 8, 2025
    Assignee: Gilead Sciences, Inc.
    Inventors: Evangelos Aktoudianakis, Aesop Cho, Michael Graupe, Lateshkumar Thakorlal Lad, Paulo A. Machicao Tello, Jonathan William Medley, Samuel E. Metobo, Devan Naduthambi, Barton W. Phillips, Scott Preston Simonovich, Peiyuan Wang, William J. Watkins, Jie Xu, Kin Shing Yang, Christopher Allen Ziebenhaus
  • KRAS G12D MODULATING COMPOUNDS
    Publication number: 20250109147
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 6, 2024
    Publication date: April 3, 2025
    Inventors: Chaodi Dai, Juan A. Guerrero, Darryl Kato, Scott E. Lazerwith, Jonathan William Medley, Thomas C.J. Mies, Hyung-Jung Pyun, Hayato Shiotsu, Maoqun Tian, William J. Watkins, Jennifer R. Zhang
  • KRAS G12D MODULATING COMPOUNDS
    Publication number: 20250101042
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 5, 2024
    Publication date: March 27, 2025
    Inventors: Wilian Augusto Cortopassi Coelho, Chaodi Dai, Juan A. Guerrero, Hongyan Guo, Darryl Kato, Scott E. Lazerwith, Jonathan William Medley, Hyung-Jung Pyun, Maoqun Tian, William J. Watkins, Jennifer R. Zhang
  • KRAS MODULATING COMPOUNDS
    Publication number: 20250059208
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: June 27, 2024
    Publication date: February 20, 2025
    Inventors: Wilian Augusto Cortopassi Coelho, Julie Farand, Michael Graupe, Juan A. Guerrero, Darryl Kato, Irene N. Kiburu, James B.C. Mack, Joshua L. Martin, Erik P. McAuley, Jonathan William Medley, Vickie H. Tsui, William J. Watkins
  • KRAS MODULATING COMPOUNDS
    Publication number: 20250042922
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: June 27, 2024
    Publication date: February 6, 2025
    Inventors: Chaodi Dai, Julie Farand, Juan A. Guerrero, Tezcan Guney, Hongyan Guo, Jason R. Hudlicky, Darryl Kato, Irene N. Kiburu, Scott E. Lazerwith, Paulo A. Machicao Tello, James B.C. Mack, Erik P. McAuley, Jessica L. McKinley, Jonathan William Medley, Hyung-Jung Pyun, Thomas P. Stratton, Maoqun Tian, Jeremy R. Tuck, William J. Watkins, Jie Xu, Jennifer R. Zhang
  • Phospholipid compounds and uses thereof
    Patent number: 12208110
    Abstract: The present disclosure relates to compounds of Formula I, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for treatment of viral infections, for example for treatment of paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: January 28, 2025
    Assignee: Gilead Sciences, Inc.
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Thomas P. Stratton, Peiyuan Wang
  • MCL1 inhibitors
    Patent number: 12202842
    Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.
    Type: Grant
    Filed: March 9, 2023
    Date of Patent: January 21, 2025
    Assignee: Gilead Sciences, Inc.
    Inventors: Hang Chu, Juan A. Guerrero, Anna E. Hurtley, Lan Jiang, Darryl Kato, Tetsuya Kobayashi, David W. Lin, Jonathan William Medley, Devan Naduthambi, Vickie H. Tsui, Chandrasekar Venkataramani, William J. Watkins, Hong Yang, Qingming Zhu
  • Substituted pyrrolizine compounds and uses thereof
    Patent number: 12161625
    Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: December 10, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Jinfa Du, Joshua A. Kaplan, Thorsten A. Kirschberg, Tetsuya Kobayashi, Scott E. Lazerwith, Rick Andrew Lee, Jonathan William Medley, Michael L. Mitchell, Philip Anthony Morganelli, Hyung-Jung Pyun, Sophia L. Shevick, Neil H. Squires, William J. Watkins
  • DIACYLGLYCEROL KINASE MODULATING COMPOUNDS
    Publication number: 20240400568
    Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
    Type: Application
    Filed: April 25, 2024
    Publication date: December 5, 2024
    Inventors: Masaaki Sawa, Mai Arai, Ryoko Nakai, Hirokazu Matsumoto, Catherine Pugh, Eric Hu, Juan Guerrero, Jesse Jacobsen, Jonathan William Medley, Jie Xu, Latesh Lad, Leena Patel, Michael Graupe, Qingming Zhu, Stephen Holmbo, Tetsuya Kobayashi, Will Watkins, Yasamin Moazami, Suet C. Yeung, Julian A. Codelli, Heath A. Weaver
  • KRAS Modulating Compounds
    Publication number: 20240383922
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: April 10, 2024
    Publication date: November 21, 2024
    Inventors: Wilian Augusto Cortopassi Coelho, Chaodi Dai, Katherine De La Fuente, Julie Farand, Juan A. Guerrero, Tezcan Guney, Hongyan Guo, Safaa S. Jamshed, Darryl Kato, Irene N. Kiburu, Scott E. Lazerwith, James B.C. Mack, Joshua L. Martin, Jessica L. McKinley, Jonathan William Medley, Hyung-Jung Pyun, Thomas P. Stratton, Rhiannon Thomas-Tran, Maoqun Tian, Vickie H. Tsui, William J. Watkins, Jie Xu, Adam D. Zajdlik, Jennifer R. Zhang
  • Diacylglycerol kinase modulating compounds
    Patent number: 12054490
    Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
    Type: Grant
    Filed: August 16, 2023
    Date of Patent: August 6, 2024
    Assignees: Gilead Sciences, Inc., Carna Biosciences, Inc.
    Inventors: Masaaki Sawa, Mai Arai, Ryoko Nakai, Hirokazu Matsumoto, Jonathan William Medley, Leena Patel, Qingming Zhu, Tetsuya Kobayashi
  • Phospholipid compounds and uses thereof
    Patent number: 12030904
    Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: July 9, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang
  • DIACYLGLYCEROL KINASE MODULATING COMPOUNDS
    Publication number: 20240182476
    Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
    Type: Application
    Filed: August 16, 2023
    Publication date: June 6, 2024
    Inventors: Masaaki Sawa, Mai Arai, Ryoko Nakai, Hirokazu Matsumoto, Catherine Pugh, Eric Hu, Juan Guerrero, Jesse Jacobsen, Jonathan William Medley, Jie Xu, Latesh Lad, Leena Patel, Michael Graupe, Qingming Zhu, Stephen Holmbo, Tetsuya Kobayashi, Will Watkins, Yasamin Moazami, Suet C. Yeung, Julian A. Codelli, Heath A. Weaver
  • Diacylglycerol kinase modulating compounds
    Patent number: 11999733
    Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: June 4, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Julian A. Codelli, Jonathan William Medley
  • Phospholipid compounds and uses thereof
    Patent number: 11963967
    Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Grant
    Filed: April 20, 2023
    Date of Patent: April 23, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Thomas P. Stratton, Peiyuan Wang
  • Diacylglyercol kinase modulating compounds
    Patent number: 11926628
    Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: March 12, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Julian A. Codelli, Michael Graupe, Juan A. Guerrero, Jesse M. Jacobsen, Tetsuya Kobayashi, Jonathan William Medley, Yasamin Moazami, Leena B. Patel, Jie Xu, Suet C. Yeung
  • PHOSPHOLIPID COMPOUNDS AND USES THEREOF
    Publication number: 20240025932
    Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
    Type: Application
    Filed: June 9, 2023
    Publication date: January 25, 2024
    Inventors: Scott E. Lazerwith, Jonathan William Medley, Philip A. Morganelli, Devan Naduthambi, Thomas P. Stratton, Peiyuan Wang
  • Diacylglycerol kinase modulating compounds
    Patent number: 11845723
    Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: December 19, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Masaaki Sawa, Mai Arai, Ryoko Nakai, Hirokazu Matsumoto, Catherine Pugh, Eric Hu, Juan Guerrero, Jesse Jacobsen, Jonathan William Medley, Jie Xu, Latesh Lad, Leena Patel, Michael Graupe, Qingming Zhu, Stephen Holmbo, Tetsuya Kobayashi, Will Watkins, Yasamin Moazami, Suet C. Yeung, Julian A. Codelli, Heath A. Weaver
  • KRAS G12D MODULATING COMPOUNDS
    Publication number: 20230374036
    Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
    Type: Application
    Filed: April 20, 2023
    Publication date: November 23, 2023
    Inventors: Chaodi Dai, Juan A. Guerrero, Tezcan Guney, Hongyan Guo, Darryl Kato, Irene N. Kiburu, Scott E. Lazerwith, Jessica L. McKinley, Jonathan William Medley, Hyung-Jung Pyun, Maoqun Tian, Vickie H. Tsui, William J. Watkins, Adam D. Zajdlik, Jennifer R. Zhang