Patents by Inventor Jonathan ZARZAR

Jonathan ZARZAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYDROXYPROPYL METHYL CELLULOSE DERIVATIVES TO STABILIZE POLYPEPTIDES
    Publication number: 20230364020
    Abstract: The present invention provides formulations comprising polypeptides and hydroxypropyl methylcellulose acetate succinate (HPMCAS) derivatives. The formulations are stable; for example, during high temperature processing and in possible low pH environments. In addition, the HPMCAS derivatives provide protection to a pH sensitive protein against acidic degradation products from aqueous hydrolysis of poly(lactic-co-glycolic acid) (PLGA) in PLGA-based delivery systems.
    Type: Application
    Filed: March 31, 2023
    Publication date: November 16, 2023
    Inventors: Purnendu Kumar NAYAK, Debby Pei-Shan CHANG, Karthikan RAJAGOPAL, Jonathan ZARZAR
  • ANTIBODY FORMULATIONS
    Publication number: 20200179516
    Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.
    Type: Application
    Filed: December 20, 2019
    Publication date: June 11, 2020
    Inventors: Yatin GOKARN, Isidro E. ZARRAGA, Jonathan ZARZAR, Thomas PATAPOFF
  • ANTIBODY FORMULATIONS
    Publication number: 20180280514
    Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.
    Type: Application
    Filed: October 18, 2017
    Publication date: October 4, 2018
    Inventors: Yatin GOKARN, Isidro E. ZARRAGA, Jonathan ZARZAR, Thomas PATAPOFF, Christine WURTH
  • Antibody formulations
    Patent number: 10010611
    Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 3, 2018
    Assignee: GENENTECH, INC.
    Inventors: Yatin Gokarn, Isidro E. Zarraga, Jonathan Zarzar, Thomas Patapoff
  • Antibody formulations
    Patent number: 9821065
    Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 21, 2017
    Assignee: GENENTECH, INC.
    Inventors: Yatin Gokarn, Isidro E. Zarraga, Jonathan Zarzar, Thomas Patapoff, Christine Wurth
  • ANTIBODY FORMULATIONS
    Publication number: 20140314748
    Abstract: The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 23, 2014
    Applicants: F. Hoffmann-La Roche AG, Genentech, Inc.
    Inventors: Yatin GOKARN, Isidro E. ZARRAGA, Jonathan ZARZAR, Thomas PATAPOFF, Christine WURTH