Patents by Inventor Jong Seog Ahn
Jong Seog Ahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240025845Abstract: Provided is a metastasis-inhibiting composition containing a methylsulfonamide-based derivative compound as an active ingredient. More specifically, the compounds inhibit the activity of chromosome segregation 1-like (CSE1L), and suppress intracellular nuclear transport to inhibit the movement and/or invasion of cancer cells, and thus effectively inhibit metastasis.Type: ApplicationFiled: September 7, 2021Publication date: January 25, 2024Inventors: Jong Seog AHN, Sung Kyun KO, Jae Hyuk JANG, Jun Pil JANG, Jae Kyung JUNG, Nam Doo KIM, Bo Yeon KIM, Joon Suk PARK
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Patent number: 11446281Abstract: The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.Type: GrantFiled: January 11, 2019Date of Patent: September 20, 2022Assignee: Korea Research Institute Of Bioscience And BiotechnologyInventors: Bo Yeon Kim, Joonsung Hwang, Nak Kyun Soung, Jong Seog Ahn, Kyung Ho Lee, Jiyun Mun, Srinivasrao Ganipisetti, Hyunjoo Cha, Mija Ahn, Hee Gu Lee, Jae-Hyuk Jang, In Ja Ryoo, Sung-Kyun Ko
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Publication number: 20220151959Abstract: A composition containing colchicine and its uses are disclosed. The composition enhances the expression amount of filaggrin that is highly related to the onset of allergic skin diseases, enhances skin moisturizing effects to thereby improve the skin barrier function, and in addition, controls inflammatory responses by allergic skin diseases. Therefore, methods for prevention and/or treatment of allergic skin diseases and/or pruritus cutaneous and skin moisturization and skin condition improvement are disclosed.Type: ApplicationFiled: February 24, 2020Publication date: May 19, 2022Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Bo Yeon KIM, Joonsung HWANG, In Ja RYOO, Nak Kyun SOUNG, Jong Seog AHN, Min Sik WOO, Kyung Ho LEE, Hee Gu LEE, Hyunjoo CHA
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Publication number: 20210292306Abstract: The present invention relates to: an indole derivative, which is a novel cell mitosis inhibitor; a stereoisomer thereof or a pharmaceutically acceptable salt thereof; a use thereof as a therapeutic agent; a composition containing the same and a treatment method using the composition; and a preparation method therefor. According to the present invention, the indole derivative, the stereoisomer thereof or the pharmaceutically acceptable salt thereof, inhibits the tubulin polymerization during mitosis so as to induce apoptosis, and has an excellent anti-cancer effect also in cancer cells having multiple drug resistance.Type: ApplicationFiled: February 13, 2017Publication date: September 23, 2021Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Bo Yeon KIM, Nak Kyun SOUNG, Srinivas Rao GANIPISETTI, Jong Seog AHN, Jae-Hyuk JANG, Sung-kyun KO, In Ja RYOO, Hyunjoo CHA, Joon Sung HWANG, Kyung Ho LEE
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Publication number: 20210030716Abstract: The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.Type: ApplicationFiled: January 11, 2019Publication date: February 4, 2021Inventors: Bo Yeon KIM, Joonsung HWANG, Nak Hyun SOUNG, Jong Seog AHN, Kyung Ho LEE, Jiyun MUN, Srinivasrao GANIPISETTI, Hyunjoo CHA, Mija AHN, Hee Gu LEE, Jae-Hyuk JANG, In Ja RYOO, Sung-Kyun KO
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Patent number: 9643959Abstract: The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.Type: GrantFiled: April 22, 2014Date of Patent: May 9, 2017Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Bo Yeon Kim, Thimmegowda N.R., Sun Ok Kim, Nak Kyun Soung, Krisada Sakchaisri, InJa Ryoo, Chan-Mi Park, Jong Seog Ahn, Jae-Hyuk Jang
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Patent number: 9433607Abstract: The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.Type: GrantFiled: March 6, 2015Date of Patent: September 6, 2016Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Bo Yeon Kim, Krisada Sakchaisri, Sun Ok Kim, Ramegowda Thimmegowda Naraganahalli, Nak Kyun Soung, Jong Seog Ahn, Joonsung Hwang, In Ja Ryoo, Jae-Hyuk Jang
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Publication number: 20160102078Abstract: The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60%, or higher, leading to a very high yield, thereby providing an effective synthesis method.Type: ApplicationFiled: April 22, 2014Publication date: April 14, 2016Inventors: Bo Yeon KIM, Thimmegowda N.R., Sun Ok KIM, Nak Kyun SOUNG, Krisada SAKCHAISRI, InJa RYOO, Chan-Mi PARK, Jong Seog AHN, Jae-Hyuk JANG
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Publication number: 20150182502Abstract: The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.Type: ApplicationFiled: March 6, 2015Publication date: July 2, 2015Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Bo Yeon Kim, Krisada Sakchaisri, Sun Ok Kim, Ramegowda Thimmegowda Naraganahalli, Nak Kyun Soung, Jong Seog Ahn, Joonsung Hwang, In Ja Ryoo, Jae-Hyuk Jang
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Patent number: 8916602Abstract: The present invention relates to novel fusarisetin compounds separated from Fusarium sp. FN080326 and having an anticancer activity, and to the use thereof. In detail, novel fusarisetin compounds separated and purified from Fusarium sp. FN080326, which is in turn separated from a soil sample, have an inhibitory activity on the proliferation and transfer of cancer cells such as breast cancer cells, liver cancer cells or myeloid leukemic cells. Therefore, the compounds can be effectively used for anticancer compositions containing the compounds as active ingredients.Type: GrantFiled: July 20, 2011Date of Patent: December 23, 2014Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Jong Seog Ahn, Jae-Hyuk Jang, Bo Yeon Kim, JunPhil Jang, Yukihiro Asami, Hyuncheol Oh
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Publication number: 20130116297Abstract: The present invention relates to novel fusarisetin compounds separated from Fusarium sp. FN080326 and having an anticancer activity, and to the use thereof. In detail, novel fusarisetin compounds separated and purified from Fusarium sp. FN080326, which is in turn separated from a soil sample, have an inhibitory activity on the proliferation and transfer of cancer cells such as breast cancer cells, liver cancer cells or myeloid leukemic cells. Therefore, the compounds can be effectively used for anticancer compositions containing the compounds as active ingredients.Type: ApplicationFiled: July 20, 2011Publication date: May 9, 2013Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Jong Seog Ahn, Jae-Hyuk Jang, Bo Yeon Kim, JunPhil Jang, Yukihiro Asami, Hyuncheol Oh
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Publication number: 20100159038Abstract: The present invention relates to an antibacterial composition including a fermented garlic solution that is fermented by lactic acid bacteria. More specifically, it provides an antibacterial substance active against gram-positive and gram-negative bacteria, yeast, and antibiotic-resistant bacteria. An antibacterial composition according to the present invention that includes a fermented garlic solution that is fermented by lactic acid bacteria as an active ingredient controls the growth of bacteria or fungi, and is thereby able to prevent and treat infections thereof.Type: ApplicationFiled: March 5, 2010Publication date: June 24, 2010Applicants: Liisna Inc., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Jong-Hwa LEE, Ji-Hyoung Woo, Ah-Rum Lee, Hyo-Bin Lim, Jung-Sook Lee, Jong-Seog Ahn
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Publication number: 20100159039Abstract: An antiviral substance including a fermentation product of garlic that is fermented by lactic acid bacteria is provided. More specifically, an antiviral agent including a fermentation product of garlic, that is fermented by lactic acid bacteria, as an active ingredient is provided. The antiviral agent including a fermentation product of garlic fermented by lactic acid bacteria is useful as a preventing or treating agent of viral infection by inhibiting viruses.Type: ApplicationFiled: March 5, 2010Publication date: June 24, 2010Applicants: Liisna Inc., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Jong-Hwa LEE, Ji-Hyoung WOO, Jung-Sook LEE, Jong-Seog AHN
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Publication number: 20100143514Abstract: An antiviral substance including a fermentation product of garlic that is fermented by lactic acid bacteria is provided. More specifically, an antiviral agent including a fermentation product of garlic, that is fermented by lactic acid bacteria, as an active ingredient is provided. The antiviral agent including a fermentation product of garlic fermented by lactic acid bacteria is useful as a preventing or treating agent of viral infection by inhibiting viruses.Type: ApplicationFiled: December 9, 2008Publication date: June 10, 2010Applicants: Liisna Inc., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Jong-Hwa LEE, Ji-Hyoung Woo, Jung-Sook Lee, Jong-Seog Ahn
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Publication number: 20090285920Abstract: The present invention relates to an antibacterial composition including a fermented garlic solution that is fermented by lactic acid bacteria. More specifically, it provides an antibacterial substance active against gram-positive and gram-negative bacteria, yeast, and antibiotic-resistant bacteria. An antibacterial composition according to the present invention that includes a fermented garlic solution that is fermented by lactic acid bacteria as an active ingredient controls the growth of bacteria or fungi, and is thereby able to prevent and treat infections thereof.Type: ApplicationFiled: August 27, 2008Publication date: November 19, 2009Applicants: Liisna Inc., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Jong-Hwa LEE, Ji-Hyoung Woo, Ah-Rum Lee, Hyo-Bin Lim, Jung-Sook Lee, Jong-Seog Ahn
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Patent number: 7060714Abstract: The invention is aimed at discovering a new type of anti-cancer compound which can exert an excellent inhibitory activity against the heparanase. A fungal strain Acremonium sp. MT70646 (KCTC 8973P) was isolated from the soil. From the culture of the isolated fungal strain, novel compounds that can inhibit both heparinase and heparanase was purified. Therefore, the present invention regards to provide a newly isolated fungal strain Acremonium sp. MT70646 (KCTC 8973P), its new products, and pharmaceutical agents such as a heparinase inhibitor, a heparanase inhibitor, a metastasis inhibitor and an angeiogenesis inhibitor all of which contain the above new compounds produced by the fungal strain as an active ingredient.Type: GrantFiled: December 19, 2000Date of Patent: June 13, 2006Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Jong Seog Ahn, Bo Yeon Kim, Won Keun Oh, Tae Ick Mheen, Dae Ook Kang, Hack Ryong Ko
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Publication number: 20030032603Abstract: The invention is aimed at discovering a new type of anti-cancer compound which can exert an excellent inhibitory activity against the heparanase. A fungal strain Acremonium sp. MT70646 (KCTC 8973P) was isolated from the soil. From the culture of the isolated fungal strain, novel compounds that can inhibit both heparinase and heparanase was purified. Therefore, the present invention regards to provide a newly isolated fungal strain Acremonium sp. MT70646 (KCTC 8973P), its new products, and pharmaceutical agents such as a heparinase inhibitor, a heparanase inhibitor, a metastasis inhibitor and an angeiogenesis inhibitor all of which contain the above new compounds produced by the fungal strain as an active ingredient.Type: ApplicationFiled: June 21, 2002Publication date: February 13, 2003Inventors: Jong Seog Ahn, Bo Yeon Kim, Won Keun Oh, Tae Ick Mheen, Soon Cheol Ahn, Dae Ook Kang, Hack Ryong Ko, Hwan Mook Kim