Patents by Inventor Jong Hee Choi

Jong Hee Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12285399
    Abstract: When used as an active ingredient, bornyl acetate or a pharmaceutically acceptable salt thereof according to the present invention exhibits the effects of alleviating behavioral scales in an animal model, inhibiting the activation of microglia and the generation of inflammatory factors (COX-2 and iNOS), and lowering nerve excitability for responsiveness to cell-neural stimuli. Thus, bornyl acetate or a pharmaceutically acceptable salt thereof is found to have an excellent stress modulating potential and to be useful for the prevention and treatment of stress-related diseases, especially, depression, thereby finding advantageous applications in related industries.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: April 29, 2025
    Assignee: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    Inventors: Ik-Hyun Cho, Jong-Hee Choi
  • Publication number: 20220151971
    Abstract: When used as an active ingredient, bornyl acetate or a pharmaceutically acceptable salt thereof according to the present invention exhibits the effects of alleviating behavioral scales in an animal model, inhibiting the activation of microglia and the generation of inflammatory factors (COX-2 and iNOS), and lowering nerve excitability for responsiveness to cell-neural stimuli. Thus, bornyl acetate or a pharmaceutically acceptable salt thereof is found to have an excellent stress modulating potential and to be useful for the prevention and treatment of stress-related diseases, especially, depression, thereby finding advantageous applications in related industries.
    Type: Application
    Filed: March 18, 2020
    Publication date: May 19, 2022
    Applicant: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    Inventors: Ik-Hyun CHO, Jong-Hee CHOI
  • Patent number: 9522911
    Abstract: The present invention relates to a novel crystalline acid salt of a tricyclic derivative or a hydrate thereof and a production method thereof. The crystalline acid salt or the hydrate thereof according to the present invention is stable with respect to humidity and stable with respect to hygroscopicity, and the quality control during manufacturing drugs is favorable. In addition, the crystalline acid salt or the hydrate thereof may be used in a pharmaceutical composition for preventing or treating neuropathic pain, epilepsy, stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, schizophrenia, chronic and acute pain, ischemic brain injury, neuronal loss after hypoxia, trauma and nerve damage, which are medical conditions induced by PARP overactivity.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: December 20, 2016
    Assignee: JEIL PHARMACEUTICAL CO., LTD.
    Inventors: In-Hae Ye, Chun-Ho Park, Jong-Hee Choi, Dong-il Kang
  • Patent number: 8906395
    Abstract: A pharmaceutical composition includes lipid nanoparticles which include two or more of a phospholipid, cholesterol, and an ionic lipid, and a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. It is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: December 9, 2014
    Assignee: Jeil Pharmaceutical Co., Ltd.
    Inventors: Myung-Hwa Kim, Kwang-Woo Chun, In-Hae Ye, Jong-Hee Choi
  • Publication number: 20140350007
    Abstract: The present invention relates to a novel crystalline acid salt of a tricyclic derivative or a hydrate thereof and a production method thereof. The crystalline acid salt or the hydrate thereof according to the present invention is stable with respect to humidity and stable with respect to hygroscopicity, and the quality control during manufacturing drugs is favorable. In addition, the crystalline acid salt or the hydrate thereof may be used in a pharmaceutical composition for preventing or treating neuropathic pain, epilepsy, stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, schizophrenia, chronic and acute pain, ischemic brain injury, neuronal loss after hypoxia, trauma and nerve damage, which are medical conditions induced by PARP overactivity.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 27, 2014
    Inventors: In-Hae YE, Chun-Ho PARK, Jong-Hee CHOI, Dong-il KANG
  • Patent number: 8815891
    Abstract: The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: August 26, 2014
    Assignee: Je Il Pharmaceutical Co., Ltd.
    Inventors: Myung-Hwa Kim, Seung-Hyun Kim, Sae-Kwang Ku, Chun-Ho Park, Bo-Young Joe, Kwang-Woo Chun, In-Hae Ye, Jong-Hee Choi, Dong-Kyu Ryu, Ji-Seon Park, Han-Chang Lee, Ji-So Choi, Young-Chul Kim
  • Patent number: 8742160
    Abstract: The present invention relates to a method for preparing a tricyclic derivative, and more particularly, to a method for preparing a tricyclic derivative intermediate with high yield and purity, the method including: introducing a hydroxy group by esterifying and substituting 2-fluoroisophthalic acid compound; introducing a piperidyl group; introducing a hydroxy group through reduction reaction; and then hydrolyzing the resultant compound, and to a method for preparing the tricyclic derivative using said intermediate. According to the method of the present invention, it is possible to provide a tricyclic derivative and an intermediate thereof with high productivity and economic feasibility as well as high purity and yield, by purifying a compound using re-crystallization unlike typical methods of using column chromatography.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: June 3, 2014
    Assignee: JE IL Pharmaceutical Co., Ltd.
    Inventors: Myung-Hwa Kim, In-Hae Ye, Jong-Hee Choi
  • Publication number: 20130101647
    Abstract: A pharmaceutical composition includes lipid nanoparticles which include two or more of a phospholipid, cholesterol, and an ionic lipid, and a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. It is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.
    Type: Application
    Filed: June 23, 2011
    Publication date: April 25, 2013
    Applicant: JEIL PHARMACEUTICAL CO., LTD.
    Inventors: Myung-Hwa Kim, Kwang-Woo Chun, In-Hae Ye, Jong-Hee Choi
  • Publication number: 20120101296
    Abstract: The present invention relates to a method for preparing a tricyclic derivative, and more particulary, to a method for preparing a tricyclic derivative inetermediate with high yield and purity, the method including: introducing a hydroxy group by esterifying and substituting 2-fluoroisophthalic acid compound; introducing a piperidyl group; introducing a hydroxy group through reduction reaction; and then hydrolyzing the resultant compound, and to a method for preparing the tricyclic derivative using said intermediate. According to the method of the present invention, it is possible to provide a tricyclic derivative and an intermediate thereof with high productivity and economic feasibility as well as high purity and yield, by purifying a compound using re-crystallization unlike typical methods of using column chromatography.
    Type: Application
    Filed: June 29, 2010
    Publication date: April 26, 2012
    Applicant: JE IL PHARMACEUTICAL CO., LTD.
    Inventors: Myung-Hwa Kim, In-Hae Ye, Jong-Hee Choi
  • Publication number: 20110218193
    Abstract: The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.
    Type: Application
    Filed: November 11, 2009
    Publication date: September 8, 2011
    Applicant: JE IL PHARMACEUTICAL CO., LTD.
    Inventors: Myung-Hwa Kim, Seung-Hyun Kim, Sae-Kwang Ku, Chun-Ho Park, Bo-Young Joe, Kwang-Woo Chun, In-Hae Ye, Jong-Hee Choi, Dong-Kyu Ryu, Ji-Seon Park, Han-Chang Lee, Ji-So Choi, Young-Chul Kim
  • Patent number: 6087722
    Abstract: A multi-chip stack package does not include a die pad. The elimination of the die pad provides more room for elements in the package which. Thus, a balanced inner package structure can be achieved, and a poor molding which may expose one of the package elements can be avoided. In the package, an upper chip is bonded to the top surface of a lower chip. To stabilize the chips, auxiliary or inner leads of a lead frame attach to the top surface of a lower chip. This shortens wire lengths between the chips and the inner leads. The shorter wires reduce wire loop heights and thus reduce the probability of exposing wires in a subsequent transfer-molding. A multi-chip stack package which includes an auxiliary lead(s) is also disclosed. The auxiliary leads attach to the top surface of the lower chip and can provide a stable support of a semiconductor chip and prevent the chip from tilting and shifting in transfer-molding. An auxiliary lead can be between the lower and upper chips.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: July 11, 2000
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kwan Jai Lee, Young Jae Song, Do Soo Jeong, Tae Je Cho, Suk Hong Chang, Chang Cheol Lee, Beung Seuck Song, Jong Hee Choi