Abstract: Long-acting glucagon like peptide 1 receptor agonists (GLP-1r agonists) reduce and inhibit pathological processes that give rise to long-term neurological impairment. A biotinylated and/or lipidated GLP-1r agonist analogs with enhanced enzymatic stability needed for gastrointestinal absorption, improved bioavailability and pharmacokinetics are described. In preferred embodiments, the GLP-1r agonist analogs have the amino acid sequence of any one of SEQ ID NOs: 9-35. The compositions are typically administered via oral or parenteral routes. The compositions are particularly suited for treating, alleviating, and/or preventing one or more neurological diseases or disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). Methods of treating a human subject having AD or PD or at risk of AD or PD are provided.

Abstract: Disclosed are a vehicle back beam capable of maximizing impact performance and reducing product weight; and a vehicle including same. According to one embodiment of the present invention, provided is a vehicle back beam which includes: a back beam body; and a back beam reinforcing part which is formed in at least one section of the back beam body and composed of a highly deformable composite material.

Abstract: A prepreg preparation device and a prepreg preparation method using the same are disclosed. According to an embodiment of the present invention, the prepreg preparation device comprises: a flow path-type impregnation part for impregnating, with a resin, a reinforced fiber transferred along a flow path; and a box-type impregnation part for impregnating, with the resin, the reinforced fiber transferred through a box-type space by passing through the flow path-type impregnation part.

Abstract: Disclosed are a vehicle back beam capable of maximizing impact performance and reducing product weight; and a vehicle including same. According to one embodiment of the present invention, provided is a vehicle back beam which includes: a back beam body; and a back beam reinforcing part which is formed in at least one section of the back beam body and composed of a highly deformable composite material.

Abstract: Provided is a reinforced composite material, comprising: a laminate of a plurality of fiber reinforced sheets; and a surface material on at least one surface of the laminate. Each of the fiber reinforced sheets comprises: a fiber reinforcing material having orientation; and a resin base material. The plurality of fiber reinforced sheets comprise: at least one first fiber reinforced sheet including a fiber reinforcing material having directionality in a first direction having an angle of +1° to +44° with respect to a reinforcement required direction; and at least one second fiber reinforced sheet including a fiber reinforcing material having directionality in a second direction having an angle of ?1° to ?44° with respect to the reinforcement required direction. The surface material comprises a metal sheet having a mesh structure. Also provided is an article including the reinforced composite material.

Abstract: Disclosed herein is a method for manufacturing a sound insulation material, a sound insulation material manufactured using this manufacturing method, and a carpet for a vehicle using the sound insulation material, and the sound insulation material is manufactured using a composite resin composition including 30 parts by weight to 70 parts by weight of aluminum oxide, 10 parts by weight to 20 parts by weight of nanoclay, 0.2 parts by weight to 0.8 parts by weight of an antioxidant, and 0.1 parts by weight to 0.5 parts by weight of a lubricant, with respect to 100 parts by weight of a base resin including PE, and the carpet for a vehicle is manufactured by coating the sound insulation material on a carpet fabric material and drying the result.

Abstract: The present disclosure relates to methods and compositions for treating and/or preventing autoimmune fibrosis, such as systemic sclerosis (SSc; scleroderma). The method includes administering to a subject in need thereof an effective amount of a death receptor agonist. Suitable death receptor agonists include tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), agonistic death receptor antibodies, and variants, analogues, or derivatives thereof. The administration of the death receptor agonist blocks fibroblast or profibrogenic cell activation, and/or reduces or depletes myofibroblasts, thereby reducing or preventing systemic sclerosis.

Abstract: Disclosed are a prepreg manufacturing device and a prepreg manufacturing method using the same. A prepreg manufacturing device according to an embodiment of the present invention comprises: a first resin inflow part which is formed inside an upper mold, receives a resin supplied from an extruder, and discharges the resin to a reinforced fiber flowing to a lower part in the upper mold; and a second resin inflow part which is formed inside a lower mold, receives the resin supplied from the extruder, and discharges the resin to the reinforced fiber flowing to an upper part of the lower mold.

Abstract: Provided is a reinforced composite material, comprising: a laminate of a plurality of fiber reinforced sheets; and a surface material on at least one surface of the laminate. Each of the fiber reinforced sheets comprises: a fiber reinforcing material having orientation; and a resin base material. The plurality of fiber reinforced sheets comprise: at least one first fiber reinforced sheet including a fiber reinforcing material having directionality in a first direction having an angle of +1° to +44° with respect to a reinforcement required direction; and at least one second fiber reinforced sheet including a fiber reinforcing material having directionality in a second direction having an angle of ?1° to ?44° with respect to the reinforcement required direction. The surface material comprises a metal sheet having a mesh structure. Also provided is an article including the reinforced composite material.

Abstract: A method for engine drivability robustness includes: dividing, by an engine controller, an engine state into a starting condition, a stop condition, and a deceleration condition; dividing an injection mode index of a fuel injection into a suction compression injection of the starting condition, a suction split injection of the stop condition, and a suction compression split injection of the deceleration condition, respectively, depending on a low volatile fuel condition; and performing a variable indexing mode to prevent an engine off by applying a lambda control factor for a rich lambda control by an increase in fuel amount to the deceleration condition.

Abstract: A prepreg preparation device and a prepreg preparation method using the same are disclosed. According to an embodiment of the present invention, the prepreg preparation device comprises: a flow path-type impregnation part for impregnating, with a resin, a reinforced fiber transferred along a flow path; and a box-type impregnation part for impregnating, with the resin, the reinforced fiber transferred through a box-type space by passing through the flow path-type impregnation part.

Abstract: Disclosed are a prepreg manufacturing device and a prepreg manufacturing method using the same. A prepreg manufacturing device according to an embodiment of the present invention comprises: a first resin inflow part which is formed inside an upper mold, receives a resin supplied from an extruder, and discharges the resin to a reinforced fiber flowing to a lower part in the upper mold; and a second resin inflow part which is formed inside a lower mold, receives the resin supplied from the extruder, and discharges the resin to the reinforced fiber flowing to an upper part of the lower mold.

Abstract: The present disclosure relates to methods and compositions for treating and/or preventing autoimmune fibrosis, such as systemic sclerosis (SSc; scleroderma). The method includes administering to a subject in need thereof an effective amount of a death receptor agonist. Suitable death receptor agonists include tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), agonistic death receptor antibodies, and variants, analogues, or derivatives thereof. The administration of the death receptor agonist blocks fibroblast or profibrogenic cell activation, and/or reduces or depletes myofibroblasts, thereby reducing or preventing systemic sclerosis.

Abstract: A method for engine drivability robustness includes: dividing, by an engine controller, an engine state into a starting condition, a stop condition, and a deceleration condition; dividing an injection mode index of a fuel injection into a suction compression injection of the starting condition, a suction split injection of the stop condition, and a suction compression split injection of the deceleration condition, respectively, depending on a low volatile fuel condition; and performing a variable indexing mode to prevent an engine off by applying a lambda control factor for a rich lambda control by an increase in fuel amount to the deceleration condition.

Abstract: Disclosed herein is a method for manufacturing a sound insulation material, a sound insulation material manufactured using this manufacturing method, and a carpet for a vehicle using the sound insulation material, and the sound insulation material is manufactured using a composite resin composition including 30 parts by weight to 70 parts by weight of aluminum oxide, 10 parts by weight to 20 parts by weight of nanoclay, 0.2 parts by weight to 0.8 parts by weight of an antioxidant, and 0.1 parts by weight to 0.5 parts by weight of a lubricant, with respect to 100 parts by weight of a base resin including PE, and the carpet for a vehicle is manufactured by coating the sound insulation material on a carpet fabric material and drying the result.

Abstract: Provided is a long fiber reinforced plastic composite material comprising: a thermoplastic plastic resin; and long fibers dispersed so as to have unidirectional orientation, wherein the content of the unidirectionally oriented long fibers is 70 to 100% by weight in the total content of the long fibers.

Abstract: A magnetic encoder type hub bearing unit may include a sealed cap which is coupled to a knuckle for fixing a hub bearing located on a hub so that an inner space for blocking the hub bearing to the outside is defined, an inner housing made of a steel material being exposed toward the inner space, an encoder which is located in the inner space while being spaced apart from a surface of the inner housing, and a WSS (Wheel Speed Sensor) which is inserted into the sealed cap such that a sensor head portion is located toward the surface of the inner housing, wherein an air gap is formed by a distance between the encoder and the surface of the inner housing and a thickness of the inner housing.

Abstract: Disclosed is a thermosetting resin composition for steel inserts, the composition including a thermosetting resin composite and a glass fiber. The thermosetting resin composite preferably includes 100 PHR of an unsaturated polyester resin, about 30 to 40 PHR of a low shrinkage agent, about 5 to 8 PHR of a release agent, about 130 to 140 PHR of a filler, about 2 to 8 PHR of a thickening agent, and about 1 to 2 PHR of a curing agent, based on 100 PHR of the unsaturated polyester resin. The thermosetting resin composition provides reduced costs and weight as compared to a steel material composed of only steel, and also exhibits physical properties comparable to the steel material.

Abstract: An ambient temperature determining modeling method using distorted ambient temperature compensation may include, (A) a distortion compensation factor applying step of applying a coolant temperature, an intake air temperature, an air volume, a vehicle speed, a soak time, and a gradient to ambient temperature determining modeling, (B) an ambient temperature learning prohibiting step of checking a “Hot Soak” condition and a “Long Idle” condition, and setting ambient temperature model learning prohibition when the “Hot Soak” condition and the “Long Idle” condition are satisfied at the same time, and (C) an ambient temperature distortion removing step of determining ambient temperature update conditions when the “Hot Soak” condition and the “Long Idle” condition are not satisfied at the same time, and adding the gradient to determine an ambient temperature.

Abstract: A magnetic encoder type hub bearing unit may include a sealed cap which is coupled to a knuckle for fixing a hub bearing located on a hub so that an inner space for blocking the hub bearing to the outside is defined, an inner housing made of a steel material being exposed toward the inner space, an encoder which is located in the inner space while being spaced apart from a surface of the inner housing, and a WSS (Wheel Speed Sensor) which is inserted into the sealed cap such that a sensor head portion is located toward the surface of the inner housing, wherein an air gap is formed by a distance between the encoder and the surface of the inner housing and a thickness of the inner housing.