Patents by Inventor Jonnes Theodorus Maria Linders

Jonnes Theodorus Maria Linders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-14 oxidation of morphine derivatives
    Publication number: 20050038250
    Abstract: The present invention relates to process for the preparation of a 14-hydroxynormorphinone derivative of formula IV comprising reacting the compound of formula III, with a cobalt (II) oxidant in the presence of a mild base and air or oxygen as the cooxidant; wherein R1 is (1C-7C)alkyl optionally substituted with one or more chlorines, butenyl, vinyl, benzyl, phenyl or naphthyl; and R2 is benzyl or benzyl substituted with one or more (1C-6C)alkoxy group or benzyl substituted with one or more halogen. The process is very suitable in the production of noroxymorphone.
    Type: Application
    Filed: August 15, 2002
    Publication date: February 17, 2005
    Inventors: Jonnes Theodorus Maria Linders, Pieter Vrijhof