Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.

Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.

Abstract: The present invention relates to a linear polyureaurethane polymer, produced without the use of any chain extender. The hard block of the resulting polymer thus consists of diisocyante groups linked to each other via without the presence of any chain extender component. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.

Abstract: The present invention relates to a linear polyureaurethane polymer, comprising in its hard blocks, at least two urea groups. The hard block of the polyureaurethane material is preferably synthesized by using diisocyante groups in the form of lysine diisocyanate (LDI). The soft block component of the polyureaurethane material is preferably poly(epsilon-caprolactone) (PCL). The invention also relates to a method of producing a polyureaurethane polymer, which in short comprises the steps of reacting a soft block component with a diisocyante group in order to prepare a prepolymer component, combining the prepolymer component with a catalyst in order to define a reaction solution and adding water to the reaction solution, preferably carried to the reaction solution in vapour phase.

Abstract: The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.

Abstract: A linear polysiloxane copolymer has at least one terminal hydroxyalkyl group. The copolymer is preparable by a process comprising a combination of a base-catalysed polymerisation with an acid-catalysed redistribution, and is suitable for preparing ophthalmic compositions for forming an intraocular lens in situ.