Abstract: Provided is a device or method for detection of leukocytes in a disease state or leukocytes in an abnormal state, or diagnosing a leukocyte-related disease, according to the device or method according to an aspect, it is possible to detect leukocytes in a disease state or leukocytes in an abnormal state at an early stage using a small amount of sample isolated from a subject, and thus, there is an effect that allows diagnosis of a leukocyte-related disease, for example, inflammation, an infectious disease, an immune disease, a metabolic disease, or cancer, etc.

Abstract: A method of removing harmful substances in blood according to an embodiment of the present disclosure is performed by a fluidic device including an inlet into which isolated blood is injected and at least one blood-clot generating and fixing unit, and the method includes injecting isolated blood into the inlet and removing harmful substances in blood by generating blood clots in the at least one blood-clot generating and fixing unit from the injected blood and fixing the blood clots.

Abstract: Provided are magnetic immunoparticles and use thereof, specifically, magnetic immunoparticles including a cell membrane capable of capturing a pathogenic material and magnetic particles attached to the cell membrane, a method of detecting pathogenic materials using the magnetic immunoparticles, and a method of diagnosing and treating an infectious disease using the magnetic immunoparticles. The magnetic immunoparticles according to an aspect may include cell membranes capable of capturing pathogenic materials, and thus may minimize side effects in vivo, and may detect various kinds of pathogenic materials due to characteristics of the cells from which the cell membranes are derived. Further, since the magnetic immunoparticles include magnetic particles, the magnetic immunoparticles may be easily separated by applying a magnetic field, and thus pathogenic materials may be more effectively detected and removed.

Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.

Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).

Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.

Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).

Abstract: One embodiment relates to a system and method by which the magnetic susceptibility of a fluid is changed to separate the fluid according to differences in magnetic susceptibility. According to one embodiment, a fluid separation system and method can efficiently separate materials contained in a fluid according to magnetic susceptibility, without damage such as hemolysis or without changes in the types or concentrations of marker proteins in plasma.

Abstract: Provided are a method of and apparatus for evaluating immune cells using magnetic particles. According to an aspect of the method, magnetic particles may be used to measure interaction of the magnetic particles with immune cells, thereby diagnosing or evaluating a degree of activation of immune cells of a subject or immune-related diseases of the subject. Further, according to an aspect of the apparatus, a phenomenon of interaction of magnetic particles and activated immune cells via endocytosis may be used to collect magnetic particle-immune cell complexes resulting from the interaction with the magnetic particles by applying a magnetic field, thereby effectively isolating the activated immune cells in a short period of time.

Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).

Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).

Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.

Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).

Abstract: A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

Abstract: A system and method for removing a target species from a fluid source is provided. The system includes a reciprocating fluid cleansing device, including a processing chamber with a port at a first end for fluid passage and a movable plunger at a second end, wherein the plunger in contact with a fluid includes a motorized mixing element for mixing the fluid with species-targeting magnetic particles. Motion of the plunger in a first direction transfers a first volume of the fluid from the fluid source into the processing chamber. Motion of the plunger in a second direction transfers the first volume of the fluid from the processing chamber to a fluid destination. At least one magnetic element provides a magnetic field gradient within the processing chamber. A connector connects the port of the first processing chamber to the fluid source and the fluid destination.

Abstract: The present invention relates to a method of separating fine particles by measuring the magnetic susceptibilities thereof using isomagnetophoresis. In a system for separating fine particles using isomagnetophoresis according to the present invention, fluids having different magnetic susceptibilities and fine particles to be measured are introduced into a microfluidic channel to form a magnetic susceptibility gradient, a strong magnetic field is applied to the channel to control the behavior of the introduced fine particles, thus moving the fine particles to respective positions at which the fluids having magnetic susceptibilities identical to those thereof is present. According to the present invention, fine particles having a fine difference in magnetic susceptibility can be separated from each other by measuring the magnetic susceptibilities thereof.

Abstract: The present invention relates to a method of separating fine particles by measuring the magnetic susceptibilities thereof using isomagnetophoresis. In a system for separating fine particles using isomagnetophoresis according to the present invention, fluids having different magnetic susceptibilities and fine particles to be measured are introduced into a microfluidic channel to form a magnetic susceptibility gradient, a strong magnetic field is applied to the channel to control the behavior of the introduced fine particles, thus moving the fine particles to respective positions at which the fluids having magnetic susceptibilities identical to those thereof is present. According to the present invention, fine particles having a fine difference in magnetic susceptibility can be separated from each other by measuring the magnetic susceptibilities thereof.