Patents by Inventor Joo-Hun Kang

Joo-Hun Kang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220072047
    Abstract: Provided are magnetic immunoparticles and use thereof, specifically, magnetic immunoparticles including a cell membrane capable of capturing a pathogenic material and magnetic particles attached to the cell membrane, a method of detecting pathogenic materials using the magnetic immunoparticles, and a method of diagnosing and treating an infectious disease using the magnetic immunoparticles. The magnetic immunoparticles according to an aspect may include cell membranes capable of capturing pathogenic materials, and thus may minimize side effects in vivo, and may detect various kinds of pathogenic materials due to characteristics of the cells from which the cell membranes are derived. Further, since the magnetic immunoparticles include magnetic particles, the magnetic immunoparticles may be easily separated by applying a magnetic field, and thus pathogenic materials may be more effectively detected and removed.
    Type: Application
    Filed: September 4, 2020
    Publication date: March 10, 2022
    Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
    Inventors: Joo Hun Kang, Seyong Kwon
  • Publication number: 20210364522
    Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
    Type: Application
    Filed: August 4, 2021
    Publication date: November 25, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo-Hun KANG, Donald E. INGBER, Michael SUPER, Alexander L. WATTERS, Harry Scott DRISCOLL
  • Publication number: 20210299676
    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
    Type: Application
    Filed: June 10, 2021
    Publication date: September 30, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo Hun KANG, Donald E. INGBER, Michael SUPER
  • Patent number: 11112410
    Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: September 7, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo-Hun Kang, Donald E. Ingber, Michael Super, Alexander L. Watters, Harry Scott Driscoll
  • Patent number: 11059050
    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: July 13, 2021
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo Hun Kang, Donald E. Ingber, Michael Super
  • Publication number: 20200261922
    Abstract: One embodiment relates to a system and method by which the magnetic susceptibility of a fluid is changed to separate the fluid according to differences in magnetic susceptibility. According to one embodiment, a fluid separation system and method can efficiently separate materials contained in a fluid according to magnetic susceptibility, without damage such as hemolysis or without changes in the types or concentrations of marker proteins in plasma.
    Type: Application
    Filed: February 7, 2020
    Publication date: August 20, 2020
    Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
    Inventors: Joo Hun Kang, Se Yong Kwon, Ji Eung Oh
  • Publication number: 20200080999
    Abstract: Provided are a method of and apparatus for evaluating immune cells using magnetic particles. According to an aspect of the method, magnetic particles may be used to measure interaction of the magnetic particles with immune cells, thereby diagnosing or evaluating a degree of activation of immune cells of a subject or immune-related diseases of the subject. Further, according to an aspect of the apparatus, a phenomenon of interaction of magnetic particles and activated immune cells via endocytosis may be used to collect magnetic particle-immune cell complexes resulting from the interaction with the magnetic particles by applying a magnetic field, thereby effectively isolating the activated immune cells in a short period of time.
    Type: Application
    Filed: November 14, 2019
    Publication date: March 12, 2020
    Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
    Inventors: Joo Hun Kang, Se Yong Kwon, Min Seok Lee
  • Publication number: 20190270091
    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
    Type: Application
    Filed: May 16, 2019
    Publication date: September 5, 2019
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo Hun KANG, Donald E. INGBER, Michael SUPER
  • Patent number: 10357780
    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: July 23, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Joo Hun Kang, Donald E. Ingber, Michael Super
  • Publication number: 20190145980
    Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
    Type: Application
    Filed: April 10, 2017
    Publication date: May 16, 2019
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo Hun KANG, Donald INGBER, Michael SUPER, Alexander WATTERS, Harry DRISCOLL
  • Publication number: 20170333914
    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).
    Type: Application
    Filed: October 27, 2015
    Publication date: November 23, 2017
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Joo Hun KANG, Donald E. INGBER, Michael SUPER
  • Publication number: 20140220617
    Abstract: A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.
    Type: Application
    Filed: April 2, 2012
    Publication date: August 7, 2014
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Chong Wing Yung, Karel Domansky, Richard Terry, David Kalish, Alexa Schulte, Joo Hun Kang, Donald E. Ingber, Michael Super, Ryan M. Cooper
  • Publication number: 20130334120
    Abstract: A system and method for removing a target species from a fluid source is provided. The system includes a reciprocating fluid cleansing device, including a processing chamber with a port at a first end for fluid passage and a movable plunger at a second end, wherein the plunger in contact with a fluid includes a motorized mixing element for mixing the fluid with species-targeting magnetic particles. Motion of the plunger in a first direction transfers a first volume of the fluid from the fluid source into the processing chamber. Motion of the plunger in a second direction transfers the first volume of the fluid from the processing chamber to a fluid destination. At least one magnetic element provides a magnetic field gradient within the processing chamber. A connector connects the port of the first processing chamber to the fluid source and the fluid destination.
    Type: Application
    Filed: June 14, 2013
    Publication date: December 19, 2013
    Inventors: Donald E. Ingber, Joo Hun Kang, Richard C. Terry, Michael Super, Ryan M. Cooper, Karel Domansky, Chong Wing Yung
  • Patent number: 8465987
    Abstract: The present invention relates to a method of separating fine particles by measuring the magnetic susceptibilities thereof using isomagnetophoresis. In a system for separating fine particles using isomagnetophoresis according to the present invention, fluids having different magnetic susceptibilities and fine particles to be measured are introduced into a microfluidic channel to form a magnetic susceptibility gradient, a strong magnetic field is applied to the channel to control the behavior of the introduced fine particles, thus moving the fine particles to respective positions at which the fluids having magnetic susceptibilities identical to those thereof is present. According to the present invention, fine particles having a fine difference in magnetic susceptibility can be separated from each other by measuring the magnetic susceptibilities thereof.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: June 18, 2013
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Je-Kyun Park, Joo-Hun Kang, Sung-Young Choi, Won-Hye Lee
  • Publication number: 20100252436
    Abstract: The present invention relates to a method of separating fine particles by measuring the magnetic susceptibilities thereof using isomagnetophoresis. In a system for separating fine particles using isomagnetophoresis according to the present invention, fluids having different magnetic susceptibilities and fine particles to be measured are introduced into a microfluidic channel to form a magnetic susceptibility gradient, a strong magnetic field is applied to the channel to control the behavior of the introduced fine particles, thus moving the fine particles to respective positions at which the fluids having magnetic susceptibilities identical to those thereof is present. According to the present invention, fine particles having a fine difference in magnetic susceptibility can be separated from each other by measuring the magnetic susceptibilities thereof.
    Type: Application
    Filed: November 19, 2008
    Publication date: October 7, 2010
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Je-Kyun Park, Joo-Hun Kang, Sung-Young Choi, Won-Hye Lee