Abstract: The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone.

Abstract: The present invention relates to a banding solution for manufacturing enteric hard capsules and an enteric hard capsule manufactured using the same, and specifically, relates to banding solution for manufacturing enteric hard capsules, which prevent the generation of a gap between the coupled capsule upper portion and capsule lower portion due to gastric acid or the separation of the capsule upper portion and the capsule lower portion during the time the enteric hard capsules stay in the stomach, and an enteric hard capsule subjected to banding treatment using the same.

Abstract: A process for preparing an acid resistant cellulose capsule. An example of a process for preparing an acid resistant cellulose capsule includes the steps of: i) preparing 100 wt part of aqueous solution of solubilized cellulose including 15-25 wt part of cellulose; ii) sequentially adding and solubilizing: 2.0-4.0 wt part of amid pectin and 0.1-1.0 wt part of iota-carrageenan as a gelling agent, an auxiliary gelling agent, a pH neutralizing agent, an emulsifying agent, a viscosity stabilizing agent and a plasticizing agent to the resulting admixture; and iii) allowing it to stand and to be equilibrated with adjustment of viscosity, before forming the capsule.

Abstract: A process for preparing an acid resistant cellulose capsule. An example of a process for preparing an acid resistant cellulose capsule includes the steps of: i) preparing 100 wt part of aqueous solution of solubilized cellulose including 15-25 wt part of cellulose; ii) sequentially adding and solubilizing: 2.0-4.0 wt part of amid pectin and 0.1-1.0 wt part of iota-carrageenan as a gelling agent, an auxiliary gelling agent, a pH neutralizing agent, an emulsifying agent, a viscosity stabilizing agent and a plasticizing agent to the resulting admixture; and iii) allowing it to stand and to be equilibrated with adjustment of viscosity, before forming the capsule.

Abstract: The present invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient. More specifically, this invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient, comprising the steps of: i) sequentially adding and solubilizing 0.1-0.5 wt part of plasticizer, 0.1-0.5 wt part of wetting agent and a small amount of a viscosity stabilizer to the 100 wt part of hypromellose aqueous dispersion containing 19-22 wt part of hypromellose; ii) adjusting the viscosity of the mixture into 800-1,300 cP; iii) dipping the mold pin into the hypromellose aqueous solution maintained at 19-21° C. after preheating the mold pin to be 100-120° C.; and iv) forming the hypromellose hard capsule.

Abstract: The present invention relates to a manufacturing method for softgel capsule containing solid and liquid formulations as core ingredient, wherein at least one pharmaceutical drug can be included in both solid formulation and liquid formulation. More particularly, this invention relates to a softgel capsule wherein liquid formulation, for example, solution and/or suspension as well as solid formulation, for example, tablet, pellet and/or sustained release dosage are present as core ingredient and its manufacturing method.

Abstract: The present invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient. More specifically, this invention relates to a process for preparing hypromellose hard capsule using thermogelation with improved storage stability, film strength, film distribution, filling up performance and/or bioavailability of ingredient, comprising the steps of: i) sequentially adding and solubilizing 0.1-0.5 wt part of plasticizer, 0.1-0.5 wt part of wetting agent and a small amount of a viscosity stabilizer to the 100 wt part of hypromellose aqueous dispersion containing 19-22 wt part of hypromellose; ii) adjusting the viscosity of the mixture into 800-1,300 cP; iii) dipping the mold pin into the hypromellose aqueous solution maintained at 19-21° C. after preheating the mold pin to be 100-120° C.; and iv) forming the hypromellose hard capsule.

Abstract: The present invention relates to a process for manufacturing pullulan hard capsules having improved film properties. More particularly, the present invention relates to a process for manufacturing pullulan hard capsules having improved film properties by solving the problems, such as, sticky among pullulan hard capsules, storage stability and/or brittleness.

Abstract: The present invention relates to a manufacturing method for softgel capsule containing solid and liquid formulations as core ingredient, wherein at least one pharmaceutical drug can be included in both solid formulation and liquid formulation. More particularly, this invention relates to a softgel capsule wherein liquid formulation, for example, solution and/or suspension as well as solid formulation, for example, tablet, pellet and/or sustained release dosage are present as core ingredient and its manufacturing method.

Abstract: The present invention relates to a non-animal soft capsule shell composition having improved disintegration stability and shell hardness. More particularly, the present invention relates to a non-animal soft capsule shell composition and to a method for preparing same, in which an antioxidant and a disintegration aid are added to the non-animal soft capsule shell composition that is typically made of starch or a starch derivative, gums, a plasticizer, a buffering agent, and purified water which inhibit starch retrogradation and thus inhibit an increase in disintegration stability and capsule shell hardness, thereby improving disintegration stability and shell hardness.

Abstract: The present invention relates to a non-animal soft capsule shell composition having improved disintegration stability and shell hardness. More particularly, the present invention relates to a non-animal soft capsule shell composition and to a method for preparing same, in which an antioxidant and a disintegration aid are added to the non-animal soft capsule shell composition that is typically made of starch or a starch derivative, gums, a plasticizer, a buffering agent, and purified water which inhibit starch retrogradation and thus inhibit an increase in disintegration stability and capsule shell hardness, thereby improving disintegration stability and shell hardness.

Abstract: A process for preparing gelatin hard capsule having enhanced film strength by the steps including i) adding 1˜10 wt part of PEG mixture of PEG 600 and PEG 1500 in weight ratio 40˜60:60˜40 to the solution having 100 wt part of gelatin; ii) adding 0.1˜1.2 wt part of emulsifier mixture containing acetyl glycerine fatty acid ester and sodium lauryl sulfate to the resulting mixture; and iii) allowing the obtained mixture to stand, adjusting its viscosity and forming a hard capsule therefrom. Further, this gelatin hard capsule has equal film distribution with minimum cracking or chipping when hygroscopic material is inserted.

Abstract: This invention provides a process for preparing a cellulose capsule enhancing mechanical film strength comprising the steps of: i) preparing 100 wt part of an aqueous solution containing 18˜21 wt part of solubilized cellulose; ii) adding 0.1˜0.5 wt part of sucrose fatty acid ester, 0.05˜0.3 wt part of potassium pyrophosphate and 0.01˜0.2 wt part of glacial acetic acid to 100 wt part of an aqueous solution of solubilized cellulose; iii) adding a mixed solution of 0.1˜1.0 wt part of iota-carageenan and 0.02˜0.5 wt part of agar to the resulting admixutre; and iv) allowing obtained product to stand, adjusting its viscosity and forming a capsule from it, wherein said forming step comprises i) dipping the mold pin into the obtained cellulose mixture at the dipping pan, ii) molding the film of the cellulose capsule, iii) cooling said film of the cellulose capsule using 15˜18° C. cooling air for 10˜20 seconds at the bottom film cooling device, iv) cooling said film of the cellulose capsule again using 15˜18° C.

Abstract: The object of the present invention is to provide a process for preparing fish gelatin capsule comprising the steps of; i) preparing a mixed solution of pectin and glycerin; ii) adding said mixed solution to solubilized fish gelatin solution; iii) adding a small amount of calcium gluconate, sucrose fatty acid esters and glacial acetic acid to said mixture, iv) standing said mixture for adjusting viscosity and v) forming a fish gelatin capsule with obtained fish gelatin mixture, wherein said forming step comprises i) dipping the mold pin into the obtained fish gelatin mixture at the dipping pan, ii) molding the film of the fish gelatin capsule, iii) cooling said film of the fish gelatin capsule using 15˜20° C. cooling air for 5˜10 seconds at the bottom film cooling device, iv) cooling said film of the fish gelatin capsule again using 15˜20° C. cooling air for 100˜120 seconds at the upper film cooling device in order to control the flow of film.

Abstract: The present invention relates to a process for preparing gelatin hard capsule having enhanced film strength by the steps comprising; i) adding 1˜10 wt part of PEG mixture of PEG 600 and PEG 1500 in weight ratio 40˜60:60˜40 to the solution having 100 wt part of gelatin; ii) adding 0.1˜1.2 wt part of emulsifier mixture containing acetyl glycerine fatty acid ester and sodium lauryl sulfate to the resulting mixture; and iii) allowing the obtained mixture to stand, adjusting its viscosity and forming a hard capsule therefrom.

Abstract: The present invention provides a process for preparing hardshell gelatin capsule reducing the static electricity and enhancing the lubrication of film having good film distribution in capsule comprising the steps of: i) preparing an emulsion containing 0.4˜0.8 part by weight of diacetylated monoglycerides, 0.05˜0.1 part by weight of sodium lauryl sulfate, and 0.005˜0.01 part by weight of colloidal silicon dioxide; ii) adding the emulsion to gelatin solution containing 100 part by weight of gelatin; iii) mixing and homogenizing the resulting solution; iv) adjusting viscosity of mixture; v) allowing the obtained product to stand; and vi) forming a hardshell gelatin capsule therefrom.

Abstract: The present invention relates to a gelatin soft capsule having the properties of removal of oral smell and cleaning of oral cavity, which contains the ingredient for masking an oral smell as an active ingredient. More particularly it relates a gelatin soft capsule comprising core ingredients and shell ingredients, wherein said core ingredients comprise i) 40˜90 wt % of at least one base material selected from safflower seed oil, olive oil and medium chain triglycerides, ii) 1˜40 wt % of natural or artificial flavor for refreshing oral cavity, iii) 0.1˜10 wt % of at least one artificial sweetener selected from saccharine, aspartam and stevioside; and said shell ingredients comprise the gelatin as a base material, glycerin, D-sorbitol, citric acid, surfactant and edible pigment.

Abstract: The present invention provides a process for preparing hardshell gelatin capsule reducing the static electricity and enhancing the lubrication of film having good film distribution in capsule comprising the steps of: i) preparing an emulsion containing 0.4˜0.8 part by weight of diacetylated monoglycerides, 0.05˜0.1 part by weight of sodium lauryl sulfate, and 0.005˜0.01 part by weight of colloidal silicon dioxide; ii) adding the emulsion to gelatin solution containing 100 part by weight of gelatin; iii) mixing and homogenizing the resulting solution; iv) adjusting viscosity of mixture; v) allowing the obtained product to stand; and vi) forming a hardshell gelatin capsule therefrom.

Abstract: The present invention relates to a gelatin soft capsule having the properties of removal of oral smell and cleaning of oral cavity, which contains the ingredient for masking an oral smell as an active ingredient. More particularly it relates a gelatin soft capsule comprising core ingredients and shell ingredients, wherein said core ingredients comprise i) 40˜90 wt % of at least one base material selected from safflower seed oil, olive oil and medium chain triglycerides, ii) 1˜40 wt % of natural or artificial flavor for refreshing oral cavity, iii) 0.1˜10 wt % of at least one artificial sweetener selected from saccharine, aspartam and stevioside; and said shell ingredients comprise the gelatin as a base material, glycerin, D-sorbitol, citric acid, surfactant and edible pigment.

Abstract: The present invention relates to a composition for refreshing oral cavity comprising i) carbonate candy, sugar alcohol or mixture of them as base material, ii) one or more refreshing functional agent selected from the group consisting of silicon dioxide, sodium silicoaluminate, calcium carbonate and silica, iii) artificial sweetener, iv) nutrient component selected from vitamin or mineral, v) natural or artificial flavor, and vi) coloring agent. Further, the composition of the present invention has the merits of convenience of portable storage and use.