Patents by Inventor Joo Hyung Heo

Joo Hyung Heo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing recombinant glycoproteins by culturing a mutant strain
    Patent number: 8685671
    Abstract: The present invention relates to a process for producing a human-type glycoprotein having reduced glycosylation by genetically manipulating an enzyme involved in glycosylation using a Hansenula polymorpha system. In detail, the present invention relates to a process for producing a human-type glycoprotein by identifying a dolichyl-phosphate-mannose dependent ?-1,3-mannosyltransferase gene from H. polymorpha, constructing a H. polymorpha mutant strain producing a glycoprotein exhibiting reduced glycosylation by disrupting the identified gene, and subjecting the mutant strain to various genetic manipulations for the synthesis of human-type glycan.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: April 1, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyun Ah Kang, Jeong Seok Park, Moo Woong Kim, Eun Jung Kim, Hye Yun Moon, Doo Byoung Oh, Joo Hyung Heo, Sang Ki Rhee
  • NOVEL HANSENULA POLYMORPHA GENE CODING FOR DOLICHYL-PHOSPHATE- MANNOSE DEPENDENT ALPHA-1,3 MANNOSYLTRANSFERASE AND PROCESS FOR THE PRODUCTION OF RECOMBINANT GLYCOPROTEINS WITH HANSENULA POLYMORPHA MUTANT STRAIN DEFICIENT IN THE SAME GENE
    Publication number: 20120202248
    Abstract: The present invention relates to a process for producing a human-type glycoprotein having reduced glycosylation by genetically manipulating an enzyme involved in glycosylation using a Hansenula polymorpha system. In detail, the present invention relates to a process for producing a human-type glycoprotein by identifying a dolichyl-phosphate-mannose dependent ?-1,3-mannosyltransferase gene from H. polymorpha, constructing a H. polymorpha mutant strain producing a glycoprotein exhibiting reduced glycosylation by disrupting the identified gene, and subjecting the mutant strain to various genetic manipulations for the synthesis of human-type glycan.
    Type: Application
    Filed: April 19, 2012
    Publication date: August 9, 2012
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyun Ah Kang, Jeong Seok Park, Moo Woong Kim, Eun Jung Kim, Hye Yun Moon, Doo Byoung Oh, Joo Hyung Heo, Sang Ki Rhee
  • gene coding for dolichyl-phosphate-mannose dependent alpha-1,3-mannosyltransferase and process for the production of recombinant glycoproteins with mutant strain deficient in the same gene
    Patent number: 8187858
    Abstract: The present invention relates to a process for producing a human-type glycoprotein having reduced glycosylation by genetically manipulating an enzyme involved in glycosylation using a Hansenula polymorpha system. In detail, the present invention relates to a process for producing a human-type glycoprotein by identifying a dolichyl-phosphate-mannose dependent ¥á-1,3-mannosyltransferase gene from H. polymorpha, constructing a H. polymorpha mutant strain producing a glycoprotein exhibiting reduced glycosylation by disrupting the identified gene, and subjecting the mutant strain to various genetic manipulations for the synthesis of human-type glycan.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: May 29, 2012
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyun Ah Kang, Jeong Seok Park, Moo Woong Kim, Eun Jung Kim, Hye Yun Moon, Doo Byoung Oh, Joo Hyung Heo, Sang Ki Rhee
  • gene coding for ? 1,6-mannosyltransferase and process for the production of recombinant glycoproteins with mutant strain deficient in the same gene
    Patent number: 7867730
    Abstract: Disclosed are a novel Hansenula polymorpha gene coding for ?-1,6-mannosyltransferase initiating outer chain elongation, an H. polymorpha mutant strain having a deficiency in the gene, and a process for producing a recombinant glycoprotein using such a mutant strain.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: January 11, 2011
    Assignee: Korea Research Institute of Biosciences and Biotechnology, Inc.
    Inventors: Hyun-Ah Kang, Moo-Woong Kim, Sang-Ki Rhee, Joo Hyung Heo
  • Novel Hansenula Polymorpha Gene Coding for Dolichyl-Phosphate- Mannose Dependent Alpha-1,3 Mannosyltransferase and Process for the Production of Recombinant Glycoproteins With Hansenula Polymorpha Mutant Strain Deficient in
    Publication number: 20100062485
    Abstract: The present invention relates to a process for producing a human-type glycoprotein having reduced glycosylation by genetically manipulating an enzyme involved in glycosylation using a Hansenula polymorpha system. In detail, the present invention relates to a process for producing a human-type glycoprotein by identifying a dolichyl-phosphate-mannose dependent ¥á-1,3-mannosyltransferase gene from H. polymorpha, constructing a H. polymorpha mutant strain producing a glycoprotein exhibiting reduced glycosylation by disrupting the identified gene, and subjecting the mutant strain to various genetic manipulations for the synthesis of human-type glycan.
    Type: Application
    Filed: October 26, 2006
    Publication date: March 11, 2010
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyun Ah Kang, Jeong Seok Park, Moo Woong Kim, Eun Jung Kim, Hye Yun Moon, Doo Byoung Oh, Joo Hyung Heo, Sang Ki Rhee
  • Novel Hansenula Polymorpha Gene Coding for Alpha 1,6-Mannosyltransferase and Process for the Production of Recombinant Glycoproteins with Hansenula Polymorpha Mutant Strain Deficient in the Same Gene
    Publication number: 20080305525
    Abstract: Disclosed are a novel Hansenula polymorpha gene coding for ?-1,6-mannosyltransferase initiating outer chain elongation in N-linked glycosylation, an H. polymorpha mutant strain having a deficiency in the gene, and a process for producing recombinant glycoprotein using such a mutant strain.
    Type: Application
    Filed: July 21, 2004
    Publication date: December 11, 2008
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyun-Ah Kang, Moo-Woong Kim, Sang-Ki Rhee, Joo Hyung Heo