Patents by Inventor Joon-Haeng Rhee

Joon-Haeng Rhee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of flagellin vaccine adjuvant-based vaccine to induce production of antibody recognizing conformation of antigens, and application thereof
    Patent number: 11771753
    Abstract: The present invention provides a vaccine composition for use in neurodegenerative diseases and an infectious virus vaccine composition for inducing an antibody recognizing the conformation of antigens. The vaccine composition of the present invention induces the production of an antibody recognizing the conformation of antigens. The antibody recognizing the conformation of antigens has high specificity for an antigen, and thus can be useful for ameliorating, preventing or treating diseases.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: October 3, 2023
    Inventors: Joon Haeng Rhee, Shee Eun Lee, Kwangjoon Jeong, Sang Chul Park, Wenzhi Tan
  • Method for inhibiting, improving, or preventing aging using recombinant fusion protein of pathogenic antigen protein and flagellin of
    Patent number: 11254714
    Abstract: The present invention relates to a method for inhibiting, improving, or preventing aging, comprising administering to a subject in need thereof a composition comprising a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, which is pneumococcal surface protein A (PsaA) of Streptococcus pneumonia. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: February 22, 2022
    Assignee: MEDISPAN CO., LTD.
    Inventors: Kyung A. Cho, Jae Sung Lim, Joon Haeng Rhee
  • PREPARATION OF FLAGELLIN VACCINE ADJUVANT-BASED VACCINE TO INDUCE PRODUCTION OF ANTIBODY RECOGNIZING CONFORMATION OF ANTIGENS, AND APPLICATION THEREOF
    Publication number: 20210100889
    Abstract: The present invention provides a vaccine composition for use in neurodegenerative diseases and an infectious virus vaccine composition for inducing an antibody recognizing the conformation of antigens. The vaccine composition of the present invention induces the production of an antibody recognizing the conformation of antigens. The antibody recognizing the conformation of antigens has high specificity for an antigen, and thus can be useful for ameliorating, preventing or treating diseases.
    Type: Application
    Filed: December 9, 2020
    Publication date: April 8, 2021
    Inventors: Joon Haeng RHEE, Shee Eun LEE, Kwangjoon JEONG, Sang Chul PARK, Wenzhi TAN
  • Preparation of flagellin vaccine adjuvant-based vaccine to induce production of antibody recognizing conformation of antigens, and application thereof
    Patent number: 10953082
    Abstract: The present invention provides a vaccine composition for use in neurodegenerative diseases and an infectious virus vaccine composition for inducing an antibody recognizing the conformation of antigens. The vaccine composition of the present invention induces the production of an antibody recognizing the conformation of antigens. The antibody recognizing the conformation of antigens has high specificity for an antigen, and thus can be useful for ameliorating, preventing or treating diseases.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: March 23, 2021
    Inventors: Joon Haeng Rhee, Shee Eun Lee, Kwangjoon Jeong, Sang Chul Park, Wenzhi Tan
  • COMPOSITION COMPRISING RECOMBINANT FUSION PROTEIN OF PATHOGENIC ANTIGEN PROTEIN AND FLAGELLIN OF VIBRIO VULNIFICUS FOR PREVENTING, ALLEVIATING, OR TREATING AGING
    Publication number: 20200031879
    Abstract: The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
    Type: Application
    Filed: July 29, 2019
    Publication date: January 30, 2020
    Inventors: Kyung A. CHO, Jae Sung LIM, Joon Haeng RHEE
  • Composition comprising recombinant fusion protein of pathogenic antigen protein and flagellin of vibrio vulnificus for preventing, alleviating, or treating aging
    Patent number: 10407471
    Abstract: The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: September 10, 2019
    Assignee: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
    Inventors: Kyung A. Cho, Jae Sung Lim, Joon Haeng Rhee
  • PREPARATION OF FLAGELLIN VACCINE ADJUVANT-BASED VACCINE TO INDUCE PRODUCTION OF ANTIBODY RECOGNIZING CONFORMATION OF ANTIGENS, AND APPLICATION THEREOF
    Publication number: 20190160163
    Abstract: The present invention provides a vaccine composition for use in neurodegenerative diseases and an infectious virus vaccine composition for inducing an antibody recognizing the conformation of antigens. The vaccine composition of the present invention induces the production of an antibody recognizing the conformation of antigens. The antibody recognizing the conformation of antigens has high specificity for an antigen, and thus can be useful for ameliorating, preventing or treating diseases.
    Type: Application
    Filed: November 17, 2016
    Publication date: May 30, 2019
    Inventors: Joon Haeng RHEE, Shee Eun LEE, Kwangjoon JEONG, Sang Chul PARK, Wenzhi TAN
  • METHOD FOR INHIBITING, IMPROVING, OR PREVENTING AGING USING RECOMBINANT FUSION PROTEIN OF PATHOGENIC ANTIGEN PROTEIN AND FLAGELLIN OF VIBRIO VULNIFICUS
    Publication number: 20190077838
    Abstract: The present invention relates to a method for inhibiting, improving, or preventing aging, comprising administering to a subject in need thereof a composition comprising a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, which is pneumococcal surface protein A (PsaA) of Streptococcus pneumonia. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 14, 2019
    Inventors: Kyung A. CHO, Jae Sung LIM, Joon Haeng RHEE
  • COMPOSITION COMPRISING RECOMBINANT FUSION PROTEIN OF PATHOGENIC ANTIGEN PROTEIN AND FLAGELLIN OF VIBRIO VULNIFICUS FOR PREVENTING, ALLEVIATING, OR TREATING AGING
    Publication number: 20180118792
    Abstract: The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
    Type: Application
    Filed: November 2, 2017
    Publication date: May 3, 2018
    Inventors: Kyung A. CHO, Jae Sung LIM, Joon Haeng RHEE
  • COMPOSITION COMPRISING RECOMBINANT FUSION PROTEIN OF PATHOGENIC ANTIGEN PROTEIN AND FLAGELLIN OF VIBRIO VULNIFICUS FOR PREVENTING, ALLEVIATING, OR TREATING AGING
    Publication number: 20160083437
    Abstract: The present invention relates to a composition for preventing, improving, or treating aging, wherein the composition comprises a recombinant protein of flagellin, which is the constituent of Vibrio vulnificus flagella, fused with a pathogenic protein antigen, as an active component. According to the present invention, the recombinant protein of the present invention can improve external and internal aging-related malfunctions and enhance immunity. Also, the composition of the present invention can easily perform immunization through mucosal administration.
    Type: Application
    Filed: March 27, 2013
    Publication date: March 24, 2016
    Inventors: Kyung A. CHO, Jae Sung LIM, Joon Haeng RHEE
  • Modified flagellin improved toll-like receptor 5 stimulating activity
    Patent number: 8337865
    Abstract: Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: December 25, 2012
    Assignee: Industry Foundation of Chonnam National University
    Inventors: Joon Haeng Rhee, Shee Eun Lee, Soo Young Kim
  • Modified flagellin improved toll-like receptor 5 stimulating activity
    Patent number: 8337864
    Abstract: Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: December 25, 2012
    Assignee: Industry Foundation of Chonnam National University
    Inventors: Joon Haeng Rhee, Shee Eun Lee, Soo Young Kim
  • MODIFIED FLAGELLIN IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY
    Publication number: 20120201855
    Abstract: Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.
    Type: Application
    Filed: December 21, 2011
    Publication date: August 9, 2012
    Applicant: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
    Inventors: Joon Haeng RHEE, Shee Eun LEE, Soo Young KIM
  • MODIFIED FLAGELLIN IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY
    Publication number: 20120201854
    Abstract: Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.
    Type: Application
    Filed: December 21, 2011
    Publication date: August 9, 2012
    Applicant: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
    Inventors: Joon Haeng RHEE, Shee Eun LEE, Soo Young KIM
  • Modified flagellin improved toll-like receptor 5 stimulating activity
    Patent number: 8236327
    Abstract: Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: August 7, 2012
    Assignee: Industry Foundation of Chonnam National University
    Inventors: Joon Haeng Rhee, Shee Eun Lee, Soo Young Kim
  • Mucosal vaccine adjuvants containing bacterial flagellins as an active component
    Patent number: 7914802
    Abstract: The present invention relates to mucosal vaccine adjuvants containing flagellins, the structural component of flagella, originated from Vibrio vulnificus, Salmonella typhimurium, and Listeria monocytogenes as an active component.
    Type: Grant
    Filed: January 12, 2005
    Date of Patent: March 29, 2011
    Assignee: Industry Foundation of Chonnam National University
    Inventors: Joon-Haeng Rhee, Shee-Eun Lee, Soo-Young Kim
  • MODIFIED FLAGELLIN IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY
    Publication number: 20110008378
    Abstract: Disclosed herein are flagellin mutants having an enhanced activity of stimulating the toll-like receptor-5 (hereinafter referred to as “TLR5”). More specifically, disclosed are flagellin mutants, prepared by point-mutating some of the amino acids of a TRL5 agonist flagellin so as to enhance the TRL-stimulating activity of the flagellin.
    Type: Application
    Filed: February 5, 2008
    Publication date: January 13, 2011
    Inventors: Joon Haeng Rhee, Shee Eun Lee, Soo Young Kim
  • Mucosal Vaccine Adjuvants Containing Bacterial Flagellins as an Active Component
    Publication number: 20080069844
    Abstract: The present invention relates to mucosal vaccine adjuvants containing flagellins, the structural component of flagella, originated from Vibrio vulnificus, Salmonella typhimurium, and Listeria monocytogenes as an active component.
    Type: Application
    Filed: January 12, 2005
    Publication date: March 20, 2008
    Applicant: CHONNAM NATONAL UNIVERSITY
    Inventors: Joon-Haeng Rhee, Shee-Eun Lee, Soo-Young Kim