Abstract: A system and method of predicting a medical diagnosis is disclosed. The method includes receiving claims data, clinical data and demographic data and detecting a prediction target for the diagnosis. If present, inputting the prediction indicator and the clinical data into a machine learning model to predict diagnosis risk, to create a diagnosis risk score; determining a care seeking propensity score, from the demographic data; weighting the diagnosis risk score by the care seeking propensity score to create a weighted diagnosis risk score; determining whether the weighted diagnosis risk score indicates a likelihood of the medical diagnosis; and, in response, transmitting a recommendation for further evaluation. The machine learning model may be trained using historical claims data, clinical data, and demographic data and may be trained to detect correlation between medical diagnosis signals identified from the training data, and a positive result from a screening mechanism the medical diagnosis.