Abstract: Disclosed are a microneedle patch including a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid, and a second hydrogel layer containing silk fibroin, and a preparation method thereof. The microneedle patch according to the present disclosure has excellent tissue adhesion, biocompatibility, and biodegradability, and is used for transdermal drug delivery to promote wound regeneration.

Abstract: A smart IC substrate according to an embodiment includes: a substrate including one surface and the other surface; a circuit pattern and a connection circuit pattern disposed on the one surface; and a coil pattern disposed on the other surface, wherein a chip mounting region is formed on the other surface, the coil pattern is electrically connected to a first terminal and a second terminal, the substrate includes a first region disposed inside the coil pattern and a second region disposed outside the coil pattern, the first terminal is disposed in the first region, the second terminal is disposed in the second region, a first via is formed in the first region corresponding to the circuit pattern of the substrate, a second via is formed in the second region of the substrate, a third via is formed in the first region corresponding to the connection circuit pattern of the substrate, and a connection member is disposed inside the second via.

Abstract: An integrated management server for a dental chart includes a memory storing instructions, and a processor. The instructions cause the processor to obtain a first script for speech of sounds generated during measurement of a patient's periodontal status to reflect the first script in a periodontal chart, provide features extracted from the periodontal chart to a pre-trained failure rate inference model to infer a failure rate for each implant type, obtain a second script for speech of sounds generated during discussions regarding a patient's implant type determined based on the inferred failure rate to reflect at least a portion of the first and second scripts in an implant chart, and obtain a third script for speech of sounds generated during discussions regarding an implant product to be used for the determined patient's implant type to reflect at least a portion of the first to third scripts in a laboratory chart.

Abstract: The present invention relates to a novel peptide compound or a pharmaceutically acceptable salt thereof.

Abstract: A speech recognition device for dentistry includes a processor, and a memory storing one or more instructions. The instructions are executed by the processor to obtain a sound containing noise and speech generated during a dental treatment, perform a noise cancelling on the sound, and run a speech-to-text (STT) model trained using a self-supervised learning method. The STT model executes extracting a feature from each of the sound with the noise cancelling and from the sound without the noise cancelling, obtaining an encoding vector by assigning a weight to each of the features and processing the features, and obtaining a script for the speech by decoding the encoding vector. Further, the self-supervised learning method includes a fine-tuning process in which sounds containing noises and speeches that are generated during the dental treatment and a script for each of the speeches are used as a training data.

Abstract: Provided herein are high-throughput, population-wide serotyping and antibody profiling assays. Disclosed variants of a Digital Serotyping assay employ next generation sequencing to measure the “serotyping profile” of barcoded subject serum antibodies tested against a range of DNA-tagged pathogen-derived antigens. The disclosed assay setup enables multiplexing in both the sample and antigen dimensions, generating a large multi-dimensional serotyping data set for more comprehensive serotyping profiling of large populations across a large number of antigens and possible pathogens. Moreover, the ability to easily scale and multiplex the number of peptide epitopes allows rapid updating of the assay content to monitor the ever-changing spectrum of pathogens. Additional applications of this technology include cancer immunology and autoimmune conditions (e.g., neoantigen or autoimmune profiling), screening for toxins, antibody therapeutics development, biosecurity, and veterinary medicine.

Abstract: The present disclosure relates to an optical laminate for a flexible display device comprising: a support substrate layer; and a hard coating layer positioned on at least one surface of the support substrate layer and having a thickness of 10 ?m to 250 ?m, wherein the hard coating layer is a polysiloxane containing 70 mol % or more of a repeating unit including an epoxy group-containing functional group; and an elastomeric polymer including polycaprolactone polyol, and wherein the polysiloxane has a number average molecular weight of more than 3,000 and less than 10,000, and a polydispersity Index (PDI) of 1.0 or more and less than 5.0, and a flexible display device including the same.

Abstract: Provided herein are high-throughput, population-wide serotyping and antibody profiling assays. Disclosed variants of a Digital Serotyping assay employ next generation sequencing to measure the “serotyping profile” of barcoded subject serum antibodies tested against a range of DNA-tagged pathogen-derived antigens. The disclosed assay setup enables multiplexing in both the sample and antigen dimensions, generating a large multi-dimensional serotyping data set for more comprehensive serotyping profiling of large populations across a large number of antigens and possible pathogens. Moreover, the ability to easily scale and multiplex the number of peptide epitopes allows rapid updating of the assay content to monitor the ever-changing spectrum of pathogens. Additional applications of this technology include cancer immunology and autoimmune conditions (e.g., neoantigen or autoimmune profiling), screening for toxins, antibody therapeutics development, biosecurity, and veterinary medicine.

Abstract: The present invention relates to a novel peptide compound or a pharmaceutically acceptable salt thereof.

Abstract: An operating method of a vaccine management device of the present invention includes: waiting, by the identification code recognition unit, recognition of an identification code; determining, when a first identification code is recognized in the first waiting step, whether the first identification code is a subject person identification code of a vaccine inoculation subject person; waiting, when the first identification code is the subject person identification code, recognition of a vaccine identification code; determining, when a second identification code is recognized in the second waiting step, whether the second identification code is the vaccine identification code; and transmitting, when the second identification code is the vaccine identification code, data obtained by merging subject person identification information corresponding to the subject person identification code and vaccine identification information corresponding to the vaccine identification code, to a management server.

Abstract: A method for controlling a vehicle includes: determining an accelerator position sensor/brake pedal position sensor (APS/BPS) command value based on a state variable and a reward variable including a prediction value for a future velocity of the vehicle predicted based on a past APS/BPS command value of the vehicle; and learning for a reward value according to the reward variable to satisfy a predetermined goal based on a change that the determined APS/BPS command value causes to at least one state variable under given environment information.

Abstract: A method for managing a chart may include recognizing speech of a user and generating same as speech data, converting the speech data to text data, extracting a system command and/or a data command from the text data, on the basis of the system command, performing starting a customer chart, ending the customer chart, and/or moving to an item included in the customer chart, extracting a diagnosis name command and a status command by parsing the data command, generating a protocol by mapping the diagnosis name command and the status command, on the basis of the protocol, changing the status of at least one of the plurality of items in the customer chart, and providing the user, in real time, with the status of an item and the changed items in the customer chart.

Abstract: The present invention relates to a cover window for a flexible display device of substrate-less type which simultaneously achieves a physical property balance between flexibility and high hardness even without a substrate film, particularly has almost no damage to the film even by repetitive bending or folding operation, and thus, can be easily applied to bendable, flexible, rollable, or foldable mobile devices, display devices, and the like, and a flexible display device including the same.

Abstract: The present disclosure provides a system and method for monitoring a floating vessel hull mooring system by determining one or more hull rotational motions of yaw, roll, and/or pitch that do not require independent knowledge of environmental conditions. The hull rotational motion of a secure and intact mooring system can be calculated and/or established experientially over time by measuring movement of the hull to characterize the hull rotational motion at given geographical positions. A compromised mooring system will result in different hull rotational motion of at least one of yaw, roll, and/or pitch. By monitoring the hull rotational motion for a given geographical position to be compared to the theoretical values (and/or previous recorded values), it is then possible to assess that at least a portion of the mooring system has been compromised and in at some embodiment indicate which portion of the mooring system has been compromised.

Abstract: The present disclosure relates to an optical laminate which hardly has a risk of damaging the film even in repetitive bending or folding operations, and thus can be easily applied to bendable, flexible, rollable or foldable mobile devices, display devices, and the like, to a cover window for flexible display device including the same, and to a flexible display device including the same.

Abstract: The present disclosure provides a system and method for monitoring a floating vessel hull mooring system by determining one or more hull rotational motions of yaw, roll, and/or pitch that do not require independent knowledge of environmental conditions. The hull rotational motion of a secure and intact mooring system can be calculated and/or established experientially over time by measuring movement of the hull to characterize the hull rotational motion at given geographical positions. A compromised mooring system will result in different hull rotational motion of at least one of yaw, roll, and/or pitch. By monitoring the hull rotational motion for a given geographical position to be compared to the theoretical values (and/or previous recorded values), it is then possible to assess that at least a portion of the mooring system has been compromised and in at some embodiment indicate which portion of the mooring system has been compromised.

Abstract: Provided herein are high-throughput, population-wide serotyping and antibody profiling assays. Disclosed variants of a Digital Serotyping assay employ next generation sequencing to measure the “serotyping profile” of barcoded subject serum antibodies tested against a range of DNA-tagged pathogen-derived antigens. The disclosed assay setup enables multiplexing in both the sample and antigen dimensions, generating a large multi-dimensional serotyping data set for more comprehensive serotyping profiling of large populations across a large number of antigens and possible pathogens. Moreover, the ability to easily scale and multiplex the number of peptide epitopes allows rapid updating of the assay content to monitor the ever-changing spectrum of pathogens. Additional applications of this technology include cancer immunology and autoimmune conditions (e.g., neoantigen or autoimmune profiling), screening for toxins, antibody therapeutics development, biosecurity, and veterinary medicine.

Abstract: This invention relates to an optical laminate comprising: a hard coating layer comprising polysiloxane; a primer layer; and an anti-finger print layer comprising a fluorine-containing compound, and having specific change in water contact angle and specific change in coefficient of friction, before and after conducting friction test on the anti-finger print layer; and a flexible display device including the same.

Abstract: The disclosure relates to biomarkers for predicting a therapeutic response of a patient to an immune therapy. Since gene signatures and markers according to an aspect have an excellent predictive capacity for predicting a patient's therapeutic response to an immune therapy, a patient group predicted to exhibit therapeutic effects may be selected to perform an appropriate treatment, and a patient's suffering and costs may be reduced.

Abstract: Provided are a composition and a kit, each for culturing natural killer cells, and a method of using the same. According to the composition for culturing natural killer cells according to aspect, and a method of culturing natural killer cells using the same, when natural killer cells are cultured in peripheral blood mononuclear cells, they are cultured in a medium including the composition for culturing natural killer cells, the composition including magnetic particles, of which at least one surface is bound with an activating receptor ligand, an inhibitory receptor ligand, a costimulatory receptor ligand, a cytokine, a cytokine receptor, an immune checkpoint ligand, a blocking antibody, or a combination thereof, thereby proliferating natural killer cells in a large quantity and promoting activation or inhibition of natural killer cells, or expansion of natural killer cells. Accordingly, the natural killer cells cultured using the same may be usefully applied to immune cell therapy products.