Patents by Inventor Joon-Mo Yang

Joon-Mo Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190233887
    Abstract: Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 ?l). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
    Type: Application
    Filed: December 19, 2018
    Publication date: August 1, 2019
    Inventors: Jon A. HOSHIZAKI, Joon Mo YANG, Maryam SHARIATI, David M. COX, Kirk M. HIRANO, John BRIDGHAM, George Stefan GOLDA, Sam Lee WOO
  • Publication number: 20190076119
    Abstract: A photoacoustic and ultrasonic endoscope includes an optical fiber, a light diffuser configured to radially diffuse a laser beam transmitted through the optical fiber, and an array transducer having a cylindrical shape and surrounding the light diffuser, the array transducer being configured to transmit the diffused laser beam therethrough and to generate an ultrasonic wave or detect an ultrasonic wave generated by an object to be examined.
    Type: Application
    Filed: September 10, 2018
    Publication date: March 14, 2019
    Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
    Inventors: Joon Mo Yang, Chae Un Kim
  • Patent number: 10105062
    Abstract: A reflection-mode photoacoustic endoscope includes a tube, a light source configured to emit a light pulse suitable for photoacoustic imaging, an ultrasonic transducer configured to detect a response signal, and a light and acoustic reflector rotatable relative to the tube.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: October 23, 2018
    Assignee: Washington University
    Inventors: Lihong Wang, Konstantin Maslov, Joon-Mo Yang
  • Publication number: 20180228464
    Abstract: A photoacoustic-ultrasonic (i.e. dual mode) endoscope includes: an optical fiber; a light diffuser configured to diffuse a laser beam delivered through the optical fiber to a target point of an object to be examined; and an array transducer through which the diffused laser beam passes and configured to generate ultrasonic waves or detect ultrasonic waves generated in the object to be examined.
    Type: Application
    Filed: January 16, 2018
    Publication date: August 16, 2018
    Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
    Inventors: Joon Mo Yang, Chae Un Kim
  • Publication number: 20180055343
    Abstract: A photoacoustic-ultrasonic dual-mode endoscope includes: a probe and a probe driving unit, wherein the probe includes: a coaxially configured optical and electromagnetic rotary waveguide assembly including an optical fiber, the optical fiber including a core and a cladding, and a conductive path coaxially arranged with the optical fiber; a scanning tip located at an end of the coaxially configured optical and electromagnetic rotary waveguide assembly and configured to deliver a laser beam to an object to be examined and detect a photoacoustic signal and an ultrasonic signal generated from the object to be examined; and a plastic catheter surrounding outer surfaces of the coaxially configured optical and electromagnetic rotary waveguide assembly and the scanning tip, wherein the conductive path includes: a first conductive path including a portion coaxially arranged with the optical fiber; and a second conductive path including a portion coaxially arranged with the optical fiber and insulated from the first co
    Type: Application
    Filed: July 10, 2017
    Publication date: March 1, 2018
    Applicant: UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECH NOLOGY)
    Inventors: Joon-Mo Yang, Chae Un Kim
  • Publication number: 20180016624
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Application
    Filed: July 24, 2017
    Publication date: January 18, 2018
    Inventors: Min YUE, David M. LIU, Joy ROY, Yuh-Min CHIANG, Joon Mo YANG, Dennis LEHTO, Charles S. VANN, Nigel P. BEARD, Ian A. HARDING, John R. Van Camp, Alexander DROMARETSKY, Sergey V. ERMAKOV, Mark F. OLDHAM, Maryam SHARIATI, Umberto ULMANELLA
  • Patent number: 9714444
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: July 25, 2017
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Min Yue, David M. Liu, Joy Roy, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John R. Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Maryam Shariati, Umberto Ulmanella
  • Publication number: 20160235305
    Abstract: A reflection-mode photoacoustic endoscope includes a tube, a light source configured to emit a light pulse suitable for photoacoustic imaging, an ultrasonic transducer configured to detect a response signal, and a light and acoustic reflector rotatable relative to the tube.
    Type: Application
    Filed: April 28, 2016
    Publication date: August 18, 2016
    Inventors: Lihong Wang, Konstantin Maslov, Joon-Mo Yang
  • Patent number: 9351705
    Abstract: A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: May 31, 2016
    Assignee: Washington University
    Inventors: Lihong Wang, Konstantin Maslov, Joon-Mo Yang
  • Publication number: 20150087530
    Abstract: Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 ?l). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
    Type: Application
    Filed: September 26, 2014
    Publication date: March 26, 2015
    Inventors: Jon A. HOSHIZAKI, Joon Mo YANG, Maryam SHARIATI, David M. COX, Kirk M. HIRANO, John BRIDGHAM, George Stefan GOLDA, Sam Lee WOO
  • Publication number: 20140162264
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Application
    Filed: December 2, 2013
    Publication date: June 12, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Min Yue, David M. Liu, Joy Roy, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John R. Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Maryam Shariati, Umberto Ulmanella
  • Publication number: 20140141438
    Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers.
    Type: Application
    Filed: October 15, 2013
    Publication date: May 22, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Maengseok Song, Joon Mo Yang, Julie C. Lee, Nigel P. Beard, Yuh-Min Chiang, Roy H. Tan, Carol Schembri
  • Patent number: 8602958
    Abstract: Assemblies for and methods of coupling a microtiter plate and receptacle for centrifugation of liquid from the microtiter plate to the receptacle are provided. In some embodiments, a coupling frame can be used. In other embodiments, the microtiter plate couples directly to the receptacle. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-y plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-z plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the y-z plane.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: December 10, 2013
    Assignee: Life Technologies Corporation
    Inventors: Patrick D. Kinney, Michele E. Wisniewski, Jon A. Hoshizaki, David M. Liu, Joon Mo Yang
  • Patent number: 8597590
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: December 3, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Min Yue, David M. Liu, Joy Roy, Yuh-Min Chiang, Joon Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John R. Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Maryam Shariati, Umberto Ulmanella
  • Patent number: 8426209
    Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: April 23, 2013
    Assignee: Celula, Inc.
    Inventors: William Frank Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel E. Raymond, Eugene Tu, Mark M. Wang, Joon Mo Yang, Rong Yang, Haichuan Zhang
  • Publication number: 20110275890
    Abstract: A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse.
    Type: Application
    Filed: January 8, 2010
    Publication date: November 10, 2011
    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Lihong Wang, Konstantin Maslov, Joon-Mo Yang
  • Publication number: 20110124111
    Abstract: Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 ?l). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
    Type: Application
    Filed: August 31, 2010
    Publication date: May 26, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jon HOSHIZAKI, Joon Mo YANG, Maryam SHARIATI, David COX, Kirk HIRANO, John BRIDGHAM, Sam WOO, George GOLDA
  • Publication number: 20110052446
    Abstract: Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods.
    Type: Application
    Filed: August 31, 2010
    Publication date: March 3, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kirk HIRANO, Mark ANDERSEN, Jian GONG, Sam WOO, David COX, Joon Mo YANG, Min YUE, Maryam SHARIATI, John BRIDGHAM, David LIU
  • Publication number: 20110020179
    Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
    Type: Application
    Filed: May 27, 2010
    Publication date: January 27, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Min Yue, David M. Liu, Yuh-Min Chiang, Joon-Mo Yang, Dennis Lehto, Charles S. Vann, Nigel P. Beard, Ian A. Harding, John Van Camp, Alexander Dromaretsky, Sergey V. Ermakov, Mark F. Oldham, Joy Roy, Maryam Shariati, Umberto Ulmanella
  • Publication number: 20100304429
    Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.
    Type: Application
    Filed: June 28, 2010
    Publication date: December 2, 2010
    Inventors: William Frank Butler, Mirianas Chachisvilis, Robert Dees, Norbert Hagen, Philippe Marchand, Daniel E. Raymond, Eugene Tu, Mark M. Wang, Joon Mo Yang, Rong Yang, Haichuan Zhang