Abstract: According to the present disclosure, an original structure of optical and ultrasonic elements as well as a probe design which enables the acquisition of optical-resolution photoacoustic endoscopic images by the way that ultrasonic beams may be emitted overlappingly (that is, collinearly) with respect to a laser beam axis along which the laser beams are emitted, in a situation where one or two transducers with acoustic focusing capability are arranged symmetrically with respect to the laser beam axis, to be described later below, to have a synthetic acoustic focusing capability, within the limited endoscopic probe space described above, by combining only an optical fiber, a GRIN lens, and a prism, has been derived.

Abstract: Provided is a wide-range vibration-free high-speed linear reciprocating scanning device capable of solving mechanical vibration problems during transfer of a scanning head. This work was supported by the IITP (Institute of Information & Communications Technology Planning & Evaluation)-ITRC (Information Technology Research Center) grant (RS-2023-00259676) and Commercialization Promotion Agency for R&D Outcomes'grant (RS-2024-00423610) funded by the Korea government (Ministry of Science and ICT).

Abstract: The present disclosure proposes a new circuit concept which may solve a problem of voltage signal level imbalance between photoacoustic and ultrasonic signals when data is collected in relation to a conventional single-element ultrasonic transducer-based, mechanical scanning integrated optical-resolution photoacoustic and ultrasonic endoscope, a mini-probe, or a catheter device and a concept which may effectively trigger a data collection device, that is, a digitizer, without losing relevant data.

Abstract: A photoacoustic-ultrasonic dual-mode endoscope includes: a probe and a probe driving unit, the probe including: a coaxially configured optical and electromagnetic rotary waveguide assembly including an optical fiber, the optical fiber including a core and a cladding, and a conductive path coaxially arranged with the optical fiber; a scanning tip located at an end of the coaxially configured optical and electromagnetic rotary waveguide assembly and configured to deliver a laser beam to an object to be examined and detect a photoacoustic signal and an ultrasonic signal generated from the object; and a plastic catheter surrounding outer surfaces of the coaxially configured optical and electromagnetic rotary waveguide assembly and the scanning tip, wherein the conductive path includes: a first conductive path including a portion coaxially arranged with the optical fiber; and a second conductive path including a portion coaxially arranged with the optical fiber and insulated from the first conductive path.

Abstract: A photoacoustic-ultrasonic dual-mode endoscope includes: a probe and a probe driving unit, wherein the probe includes: a coaxially configured optical and electromagnetic rotary waveguide assembly including an optical fiber, the optical fiber including a core and a cladding, and a conductive path coaxially arranged with the optical fiber; a scanning tip located at an end of the coaxially configured optical and electromagnetic rotary waveguide assembly and configured to deliver a laser beam to an object to be examined and detect a photoacoustic signal and an ultrasonic signal generated from the object to be examined; and a plastic catheter surrounding outer surfaces of the coaxially configured optical and electromagnetic rotary waveguide assembly and the scanning tip, wherein the conductive path includes: a first conductive path including a portion coaxially arranged with the optical fiber; and a second conductive path including a portion coaxially arranged with the optical fiber and insulated from the first co

Abstract: A photoacoustic-ultrasonic endoscope includes a probe and a driving unit providing rotational power and pullback translational motion to the probe, wherein the probe includes a catheter tubing extending in one direction and having an interior that is hollow, one end of the catheter tubing being closed and the other end of the catheter tubing being open, a fastening nut that is fastened to the other end of the catheter tubing and has a through hole corresponding to the interior of the catheter tubing, a pullback shaft extending into the interior of the catheter tubing through the through hole of the fastening nut and having an interior that is hollow, and a radial shaft seal interposed between the fastening nut and the pullback shaft and surrounding the pullback shaft around a central axis of the through hole of the fastening nut.

Abstract: A photoacoustic-ultrasonic dual-mode endoscope includes: a probe and a probe driving unit, wherein the probe includes: a coaxially configured optical and electromagnetic rotary waveguide assembly including an optical fiber, the optical fiber including a core and a cladding, and a conductive path coaxially arranged with the optical fiber; a scanning tip located at an end of the coaxially configured optical and electromagnetic rotary waveguide assembly and configured to deliver a laser beam to an object to be examined and detect a photoacoustic signal and an ultrasonic signal generated from the object to be examined; and a plastic catheter surrounding outer surfaces of the coaxially configured optical and electromagnetic rotary waveguide assembly and the scanning tip, wherein the conductive path includes: a first conductive path including a portion coaxially arranged with the optical fiber; and a second conductive path including a portion coaxially arranged with the optical fiber and insulated from the first co

Abstract: A photoacoustic-ultrasonic dual-mode endoscope includes: a probe and a probe driving unit, wherein the probe includes: a coaxially configured optical and electromagnetic rotary waveguide assembly including an optical fiber, the optical fiber including a core and a cladding, and a conductive path coaxially arranged with the optical fiber; a scanning tip located at an end of the coaxially configured optical and electromagnetic rotary waveguide assembly and configured to deliver a laser beam to an object to be examined and detect a photoacoustic signal and an ultrasonic signal generated from the object to be examined; and a plastic catheter surrounding outer surfaces of the coaxially configured optical and electromagnetic rotary waveguide assembly and the scanning tip, wherein the conductive path includes: a first conductive path including a portion coaxially arranged with the optical fiber; and a second conductive path including a portion coaxially arranged with the optical fiber and insulated from the first co

Abstract: A reflection-mode photoacoustic endoscope includes a tube, a light source configured to emit a light pulse suitable for photoacoustic imaging, an ultrasonic transducer configured to detect a response signal, and a light and acoustic reflector rotatable relative to the tube.

Abstract: A photoacoustic-ultrasonic dual-mode endoscope includes: a probe and a probe driving unit, wherein the probe includes: a coaxially configured optical and electromagnetic rotary waveguide assembly including an optical fiber, the optical fiber including a core and a cladding, and a conductive path coaxially arranged with the optical fiber; a scanning tip located at an end of the coaxially configured optical and electromagnetic rotary waveguide assembly and configured to deliver a laser beam to an object to be examined and detect a photoacoustic signal and an ultrasonic signal generated from the object to be examined; and a plastic catheter surrounding outer surfaces of the coaxially configured optical and electromagnetic rotary waveguide assembly and the scanning tip, wherein the conductive path includes: a first conductive path including a portion coaxially arranged with the optical fiber; and a second conductive path including a portion coaxially arranged with the optical fiber and insulated from the first co

Abstract: A reflection-mode photoacoustic endoscope includes a tube, a light source configured to emit a light pulse suitable for photoacoustic imaging, an ultrasonic transducer configured to detect a response signal, and a light and acoustic reflector rotatable relative to the tube.

Abstract: A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse.

Abstract: A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse.

Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

Abstract: This invention of an apparatus and a method for detecting luminescence from biological systems in response to magnetic fields measures the amount of light emitted when impressing a magnetic field on a living thing, a tissue or cells separated from a living thing to evaluate the effect of magnetic fields on biological systems. The apparatus of this invention consists of a dark box which shields a biological sample from external light, a magnetic field generator which is arranged adjacent to the biological sample to impress a magnetic field on it, and a photodetector which detects the light emitted from the biological sample exposed to the magnetic field from the said magnetic generator.

Abstract: A mixed green light-emitting phosphor for a fluorescent screen of a projection cathode ray tube is prepared by mixing LaOCl phosphor activated with Tb with at least a mixture of phosphors selected from the group of a Y.sub.3 (Al,Ga).sub.5 O.sub.12 phosphor activated with Tb and a Zn.sub.2 SiO.sub.4 phosphor activated with Mn, a Y.sub.3 (Al,Ga).sub.5 O.sub.12 phosphor activated with Tb and a InBo.sub.3 phosphor activated with Tb, or a InBO.sub.3 phosphor activated with Tb and a Zn.sub.2 SiO.sub.4 phosphor activated with Mn. The fluorescent screen of the cathode ray tube is tested under standard drive conditions. From the test results, it is noted that the characteristics of the brightness and the C.I.E. coordinates of the fluorescent screen using the mixed green light-emitting phosphors is remarkably improved compared with that of the conventional Y.sub.3 Al.sub.5 O.sub.12 phosphor activated with Tb.