Patents by Inventor Joong Ku Lee

Joong Ku Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10751378
    Abstract: The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-?, or MIP-2.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: August 25, 2020
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sei Ryang Oh, Kyung Seop Ahn, Seung Hyung Kim, In Sik Shin, Hang Jin, Jung Hee Kim, Hyung Won Ryu, Wan Yi Li, Sang Woo Lee, Joong Ku Lee, Sang Ho Choi
  • Patent number: 10413579
    Abstract: The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: September 17, 2019
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, In Sik Shin, Hyung Won Ryu, Sang Woo Lee, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi, Doo Young Kim, Jung Hee Kim, Li Wan Yi, Jin Hang
  • Publication number: 20170173095
    Abstract: The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss.
    Type: Application
    Filed: July 1, 2014
    Publication date: June 22, 2017
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, In Sik Shin, Hyung Won Ryu, Sang Woo Lee, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi, Doo Young Kim, Jung Hee Kim, Li Wan Yi, Jin Hang
  • Patent number: 9610310
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases or asthma comprising a Lagerstroemia ovalifolia extract or a fraction thereof as an active ingredient, and a health functional food and a feed additive for preventing or improving inflammatory diseases or asthma comprising the extract or the fraction as an active ingredient.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: April 4, 2017
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, Fifit Juniarti, Rifatul Widjhati, Ji Won Park, Jin Hyub Paik, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi
  • Publication number: 20170035822
    Abstract: The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-?, or MIP-2.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 9, 2017
    Inventors: Sei Ryang OH, Kyung Seop AHN, Seung Hyung KIM, In Sik SHIN, Hang JIN, Jung Hee KIM, Hyung Won RYU, Wan Yi LI, Sang Woo LEE, Joong Ku LEE, Sang Ho CHOI
  • Patent number: 8974837
    Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: March 10, 2015
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyeong Kyu Lee, Sei Ryang Oh, Kyung Seop Ahn, Sang Ku Lee, Joong Ku Lee, Ok Kyoung Kwon, Doo Young Kim, Hyouk Joung, Gui Hua Quan, Mi Jin Kim, Bo Young Park
  • Publication number: 20140370126
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases or asthma comprising a Lagerstroemia ovalifolia extract or a fraction thereof as an active ingredient, and a health functional food and a feed additive for preventing or improving inflammatory diseases or asthma comprising the extract or the fraction as an active ingredient.
    Type: Application
    Filed: December 28, 2012
    Publication date: December 18, 2014
    Inventors: Kyung Seop Ahn, Sei Ryang Oh, Ok Kyoung Kwon, Fifit Juniarti, Rifatul Widjhati, Ji Won Park, Jin Hyub Paik, Joong Ku Lee, Hyeong Kyu Lee, Sang Ho Choi
  • Patent number: 8455541
    Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: June 4, 2013
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyeong Kyu Lee, Sei Ryang Oh, Kyung Seop Ahn, Sang Ku Lee, Joong Ku Lee, Ok Kyoung Kwon, Doo Young Kim, Hyouk Joung, Gui Hua Quan, Mi Jin Kim, Bo Young Park
  • Publication number: 20120184499
    Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Hyeong Kyu LEE, Sei Ryang-Oh, Kyung Seop AHN, Sang Ku LEE, Joong Ku LEE, Ok Kyoung KWON, Doo Young KIM, Hyouk JOUNG, Gui Hua QUAN, Mi Jin KIM, Bo Young PARK
  • Publication number: 20120183632
    Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Hyeong Kyu LEE, Sei Ryang OH, Kyung Seop AHN, Sang Ku LEE, Joong Ku LEE, Ok Kyoung KWON, Doo Young KIM, Hyouk JOUNG, Gui Hua QUAN, Mi Jin KIM, Bo Young PARK
  • Patent number: 8168235
    Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: May 1, 2012
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyeong Kyu Lee, Sei Ryang Oh, Kyung Seop Ahn, Sang Ku Lee, Joong Ku Lee, Ok Kyoung Kwon, Doo Young Kim, Hyouk Joung, Gui Hua Quan, Mi Jin Kim, Bo Young Park
  • Patent number: 7763286
    Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: July 27, 2010
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyeong Kyu Lee, Sei Ryang Oh, Kyung Seop Ahn, Joong Ku Lee, Sang Ku Lee, Jung Hee Kim, Doo Young Kim, Gui Hua Quan, Ok Kyoung Kwon, Eun Ah Kim, Soon Ja Choi, Guang Hai Shen, Mi Jin Kim, Bo Young Park, Byung Sun Min, Gyoon Hee Han, Hea Young Park, Gun Cheol Kim, Joo Heon Kim, So Young Kim
  • Publication number: 20090324750
    Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and cosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Application
    Filed: May 30, 2006
    Publication date: December 31, 2009
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Hyeong Kyu Lee, Sei Ryang Oh, Kyung Seop Ahn, Sang Ku Lee, Joong Ku Lee, Ok Kyoung Kwon, Doo Young Kim, Hyouk Joung, Gui Hua Quan, Mi Jin Kim, Bo Young Park
  • Publication number: 20090148542
    Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
    Type: Application
    Filed: July 18, 2006
    Publication date: June 11, 2009
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Hyeong Kyu Lee, Sei Ryang Oh, Kyung Seop Ahn, Joong Ku Lee, Sang Ku Lee, Jung Hee Kim, Doo Young Kim, Gui Hua Quan, Ok Kyoung Kwon, Eun Ah Kim, Soon Ja Choi, Guang Hai Shen, Mi Jin Kim, Bo Young Park, Byung Sun Min, Gyoon Hee Han, Hea Young Park, Gun Cheol Kim, Joo Heon Kim, So Young Kim