Patents by Inventor Joost MELIS

Joost MELIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTISPECIFIC ANTIGEN-BINDING MOLECULE WITH IMPROVED INTERNALIZATION CHARACTERISTICS
    Publication number: 20230076417
    Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10?9 and 10?8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
    Type: Application
    Filed: April 6, 2022
    Publication date: March 9, 2023
    Inventors: Bart DE GOEIJ, Joost MELIS, Tom VINK, Hendrik TEN NAPEL, Esther BREIJ, David SATIJN, Paul PARREN
  • MULTISPECIFIC ANTIGEN-BINDING MOLECULE WITH IMPROVED INTERNALIZATION CHARACTERISTICS
    Publication number: 20190352423
    Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10?9 and 10?8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
    Type: Application
    Filed: February 3, 2017
    Publication date: November 21, 2019
    Inventors: Bart DE GOEIJ, Joost MELIS, Tom VINK, Hendrik TEN NAPEL, Esther BREIJ, David SATIJN, Paul PARREN