Patents by Inventor Jordan L. Holtzman

Jordan L. Holtzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELLULAR AND ANIMAL MODELS FOR SCREENING THERAPEUTIC AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20150177227
    Abstract: Constructs, models, and methods to assay candidate therapeutic agents to treat Alzheimer's disease are described herein.
    Type: Application
    Filed: July 15, 2013
    Publication date: June 25, 2015
    Inventor: Jordan L. HOLTZMAN
  • Complex of a chaperone with ?-amyloid and methods employing this complex
    Patent number: 8211658
    Abstract: A chaperone protein Q2 and ?-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood of developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in ?-amyloid aggregation. The method may further include screening for an apolipoprotein E genotype, which is associated with Alzheimer's disease.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: July 3, 2012
    Inventor: Jordan L. Holtzman
  • COMPLEX OF A CHAPERONE WITH BETA-AMYLOID AND METHODS EMPLOYING THIS COMPLEX
    Publication number: 20110256569
    Abstract: A chaperone protein Q2 and ?-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood of developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in ?amyloid aggregation. The method may further include screening for an apolipoprotein E genotype, which is associated with Alzheimer's disease.
    Type: Application
    Filed: April 19, 2011
    Publication date: October 20, 2011
    Inventor: Jordan L. Holtzman
  • Complex of a chaperone with ?-amyloid and methods employing this complex
    Patent number: 7927824
    Abstract: A chaperone protein Q2 and ?-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood of developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in ?-amyloid aggregation. The method may further include screening for an apolipoprotein E genotype, which is associated with Alzheimer's disease.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: April 19, 2011
    Inventor: Jordan L. Holtzman
  • Complex of a chaperone protein with amyloid
    Patent number: 6972318
    Abstract: A chaperone protein Q2 and ?-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for detecting the Q2 level is a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood for developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in ?-amyloid aggregation. The method may further include screening for an apolipoprotein E genetype, which is associated with Alzheimer's disease.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: December 6, 2005
    Inventor: Jordan L. Holtzman