Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PD-1 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

Abstract: In at least one aspect, the invention comprises a method comprising the steps of: identifying a first portfolio of securities as corresponding, at a specified time, to an index; calculating, for the first portfolio, a first set of performance values comprising one or more of: book yield, book income, and book return; calculating, for a second portfolio of securities, a second set of performance values corresponding to the first set of performance values; and comparing the second set of performance values to the first set of performance values to obtain a performance measure for the second portfolio.

Abstract: An improved computerized tomography method and an apparatus for performing the method are used for construction of visual images of a subject utilizing a Radon transform inversion scheme of lower computational complexity. A multiscale backprojection with a postprocessing step is utilized instead of a conventional backprojection algorithm or direct Fourier method to obtain improved images. Multilevel methods can be applied under weaker regularity requirements than Fourier methods, so the present algorithm can be adjusted to provide different resolutions for different parts of the reconstruction, whether or not the Radon data are equally spaced.