Publication number: 20070088026
Abstract: 5-Phenylpyrimidines of the formula I, in which the substituents have the following meanings: R1 is a five- to ten-membered saturated, partially unsaturated or aromatic mono- or bicyclic heterocycle comprising one to four hetero atoms selected from the group consisting of O, N or S, which heterocycle can be substituted as defined in the description, R2 is hydrogen, halogen, cyano, alkyl, haloalkyl or alkoxy; R3, R4 are hydrogen, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, cycloalkenyl, alkynyl, haloalkynyl or cycloalkynyl, R3 and R4 together with the nitrogen atom to which they are bonded may also form a five- or six-membered ring which can be interrupted by a hetero atom and have attached to it one or more substituents; R5, R6 are hydrogen, halogen, alkyl, haloalkyl or alkoxy; R7, R8 are hydrogen, halogen, alkyl or haloalkyl; R9 is hydrogen, halogen, alkyl, alkoxy, cycloalkoxy, haloalkoxy or alkoxycarbonyl, Processes and intermediates for the preparation of these compounds, a
Type:
Application
Filed:
October 12, 2006
Publication date:
April 19, 2007
Inventors:
Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schafer, Frank Schieweck, Hubert Sauter, Markus Gewehr, Bernd Muller, Jordi i Blasco, Eberhard Ammermann, Siegfried Strathmann, Gisela Lorenz, Reinhard Stierl
Publication number: 20060229328
Abstract: 2-Substituted pyrimidines of the formula I in which the index n and the substituents L, Ra, Rb, Rc, Rz, Ru, Rv, A?, A? and A?? are as defined in the description and: R1 is C3-C10-alkyl, C3-C10-alkenyl, C3-C10-alkynyl, C3-C12-cycloalkyl, C3-C10-cycloalkenyl or a five- to ten-membered saturated, partially unsaturated or aromatic heterocycle which is attached via carbon and contains one to four heteroatoms from the group consisting of O, N and S, R2 is halogen, cyano, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-alkoxy, C3-C4-alkenyloxy or C3-C4-alkynyloxy, where the alkyl, alkenyl and alkynyl radicals of R2 may be substituted by halogen, cyano, nitro, C1-C2-alkoxy or C1-C4-alkoxycarbonyl, and R3 is cyano, CO2Ra, C(?O)NRzRb, C(?O)—N—ORb, C(?S)—NRaRb, C(?NORa)NRzRb, C(?NRa)NRzRb, C(?O)NRa—NRzRb, C(?N—NRzRc)NRaRb, C(?O)Ra, C(?NORb)Ra, C(?N—NRzRb)Ra, CRaRb—ORz, CRaRb—NRzRc, ON(?CRaRb), O—C(?O)Ra, NRaRb?, NRa(C(?O)Rb), NRa(C(?O)ORb), NRa(C(?O)—NRzRb), NRa(C(?NRc)Rb), NRa(N?CRcRb), NRa—NRzRb, NRz—ORa, N
Type:
Application
Filed:
March 30, 2004
Publication date:
October 12, 2006
Inventors:
Jordi i Blasco, Carsten Blettner, Bernd Muller, Markus Gewehr, Wassilios Grammenos, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schafer, Frank Schieweck, Anja Schwogler, Oliver Wagner, Maria Scherer, Siegfried Strathmann, Ulrich Schofl, Reinhard Stierl
Publication number: 20060199801
Abstract: Bicyclic compounds of the formula I in which A1 or A5 is C and the other of the two variables A1, A5 is N, C or C—R3; A2, A3, A4 independently of one another are N or C—R3a, where one of the variables A2, A3 or A4 may also be S or a group N—R4 if A1 and A5 are both C, and where A4 is not N or C—R3a if A1 is N, A3 is C—R3a and A5 is C, and where A1 is attached to A2 and A3 to A4 or A2 is attached to A3 and A4 to A5 or A1 is attached to A5 and A2 to A3 or A1 is attached to A5 and A3 to A4 or A1 is attached to A2 and A4 to A5 by double bonds; n is 0, 1, 2, 3, 4 or 5; Ra is halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, C2-C6-alkenyl, C2-C6-alkenyloxy or C(O)R5; R1 is halogen, cyano, C1-C10-alkyl, where a carbon atom of the C1-C10-alkyl radical may be replaced by a silicium atom, C1-C6-haloalkyl, C2-C10-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, where the cycloalkyl moiety of the two last-mentioned groups may be unsu
Type:
Application
Filed:
April 16, 2004
Publication date:
September 7, 2006
Inventors:
Jordi i Blasco, Carsten Blettner, Bernd Muller, Markus Gewehr, Wassilios Grammenos, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Peter Schafer, Frank Schieweck, Anja Schwogler, Oliver Wagner, Eberhard Ammermann, Siegfried Strathmann, Ulrich Schofl, Maria Scherer, Reinhard Stierl
Publication number: 20050261314
Abstract: The invention relates to 7-amino triazolopyrimidines of formula (I), in which the substituents have the following meanings: R1, R2 represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl; or 5-membered or 6-membered heterocyclyl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom; or 5-membered or 6-membered heteroaryl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom, or R1 and R2 can, together with the nitrogen atom, which binds them, form a 5-membered or 6-membered ring containing one to four nitrogen atoms or one to three nitrogen atoms and one sulfur or oxygen atom; R3 represents alkyl, alkenyl, alkynyl, cycloalkyl, phenylalkyl and alkyl halide; whereby R3 and R2 can be unsubstituted or partially or completely substituted according to the description; X represents halogen, cyano, alkoxy, alkyl halide, phenyl or phenyl that is substituted by Ra.
Type:
Application
Filed:
July 16, 2002
Publication date:
November 24, 2005
Inventors:
Jordi i Blasco, Hubert Sauter, Bernd Muller, Markus Gewehr, Wassilios Grammenos, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schafer, Frank Schieweck, Eberhard Ammermann, Siegfried Strathmann, Gisela Lorenz, Reinhard Stierl
Publication number: 20050090665
Abstract: Triazolopyrimidines of formula (I), wherein the index and substituents have the following meaning: n=0 or a whole number of 1-5; R=halogen, cyano, hydroxy, cyanate, alkyl, alkenyl, alkinyl, halogenalkyl, halogenalkenyl, alkoxy, alkenyloxy, alkinyloxy, halogenalkoxy, cycloalkyl, cycloalkenyl, cycloalkoxy, alkoxycarbonyl, alkenyloxycarbonyl, alkinyloxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkoximinoalkyl, alkenyloximinocarbonyl, alkinyloximinoalkyl, alkylcarbonyl, alkenylcarbonyl, alkinylcarbonyl, cycloalkylcarbonyl or a five to ten membered saturated, partially unsaturated or aromatic heterocycle, containing one to four heteroatoms from the group O, N or S; R1=alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, phenyl, naphthyl or a five to ten membered saturated, partially unsaturated or aromatic heterocycle, containing one to four heteroatoms from the group O, N or S, R and/or R1 being able to be substituted according to the description; R2=alkyl, alkenyl or alkinyl which can be s
Type:
Application
Filed:
July 3, 2002
Publication date:
April 28, 2005
Inventors:
Bernd Muller, Hubert Sauter, Markus Gewehr, Wassilios Grammenos, Jordi I Blasco, Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schafer, Frank Schieweck, Michael Rack, Gisela Lorenz, Siegfried Strathmann, Eberhard Ammermann, Reinhard Stierl