Abstract: The present invention relates to a handling installation for handling sheets of cardboard or similar material applicable for implementation thereof in an automated production facility, comprising a first receiving station (1) configured to receive packages formed by cardboard sheets, each of the sheets being defined by four sides, and a second distribution station (2) in which the sheets are delivered face-down coming from the receiving station by means of sheet handling means. The first and second stations comprise modules that are independent from each other, the handling means comprising a robot arm provided with a head with clamping means to hold the package of sheets on any of the four sides, the head having a hinge point that can be coupled to a robot arm, capable of conveniently moving and orienting the clamping means in any of the coordinate axes, the robot arm being mounted on a base that is independent with respect to the first and second stations.

Abstract: A trolley device is used to convey laminar elements. The trolley device includes at least one belt that defines a closed loop, a plurality of pulleys, at least one drive pulley being configured to act on the belt, the pulleys being mounted on a frame with a supporting region over which a section of the belt can be slid and wherein suction means linked to the belt are provided. The belt includes at least on the outer face thereof a projecting section of predetermined length that protrudes in height with respect to the rest of the belt, the projecting section being provided with a plurality of through holes aligned in position with through holes made in the belt.

Abstract: This invention relates to a process for preparing Sugammadex or its salts, preferably Sugammadex sodium, with a low content of organic solvents, preferably water-miscible organic solvents, more preferably ethanol, 2-propanol and/or acetone. The process comprises exposing Sugammadex or its salts, preferably Sugammadex sodium, to a medium with a high relative humidity.

Abstract: A trolley device is used to convey laminar elements. The trolley device includes at least one belt that defines a closed loop, a plurality of pulleys, at least one drive pulley being configured to act on the belt, the pulleys being mounted on a frame with a supporting region over which a section of the belt can be slid and wherein suction means linked to the belt are provided. The belt includes at least on the outer face thereof a projecting section of predetermined length that protrudes in height with respect to the rest of the belt, the projecting section being provided with a plurality of through holes aligned in position with through holes made in the belt.

Abstract: This invention relates to an improved process for the synthesis of Sugammadex or a salt thereof, to Sugammadex or a salt thereof having high purity as obtained by said process and to pharmaceutical compositions comprising said high purity Sugammadex or a salt thereof.

Abstract: A method for feeding laminar elements into an introducer associated with a graphic printing station provided for printing at least one of the faces of the laminar element, wherein a plurality of laminar elements are grouped in an orderly manner in a stacked group of laminar elements that extends upwards, such that the longitudinal axis of each of the laminar elements is located perpendicular with respect to an advance direction of the group, the advance direction of the group being perpendicular to the advance direction of the introducer. This group of laminar elements is turned 180 degrees with respect to a rotation axis that is parallel to the advance direction of the introducer, such that the upper face of each one of the laminar elements is oriented downwards, the turned laminar element advancing in a direction perpendicular to the advance direction of the introducer.

Abstract: The present invention relates to a process for preparing lifitegrast or a salt thereof, wherein the process comprises hydrogenation of compound II in a mixture comprising at least one solvent selected from the group consisting of acetonitrile, a ketone solvent, an ester solvent and a mixture thereof, preferably acetonitrile.

Abstract: This invention relates to an improved process for the synthesis of Sugammadex or a salt thereof, to Sugammadex or a salt thereof having high purity as obtained by said process and to pharmaceutical compositions comprising said high purity Sugammadex or a salt thereof.

Abstract: The present invention relates to a process for preparing lifitegrast or a salt thereof, wherein the process comprises hydrogenation of compound II in a mixture comprising at least one solvent selected from the group consisting of acetonitrile, a ketone solvent, an ester solvent and a mixture thereof, preferably acetonitrile.

Abstract: The invention relates to an installation for printing and die-cutting laminar bodies, which comprises a digital printing station (1) for printing at least one face of the laminar bodies, and a die-cutting station (2) for die-cutting the laminar bodies coming from the digital printing station (1), comprising first conveying means (3) for moving the laminar bodies (P) positioned between the digital printing station (1) and a redirection station (5), and second conveying means (4) for moving the laminar bodies between the outlet of the redirection station (5) and the die-cutting station (2), The digital printing station defines an axial direction of travel and the die-cutting station (2) defines an axial direction of travel that is perpendicular to the axial direction of travel of the laminar bodies in the digital printing station (1), such that an L-shaped path of the laminar bodies (P), viewed in the plan view, is defined.

Abstract: The present disclosure relates to a container for the production of a foamed sclerosant composition, to kits and systems including such a container, to methods for preparing a foamed sclerosant composition using such containers, and to a foamed sclerosant compositions obtainable by such methods. In an aspect, the container comprises a container body and a mixing element disposed in the container body, such that a foaming space is defined in an interior of the container body between the sidewalls and the mixing element. The mixing element may be configured to be operatively coupled with a rotating actuator without the actuator reaching the foaming space.

Abstract: An insertion assembly for the continuous and automated feeding of laminar elements into a graphic printing station without the involvement of roller elements in the process, allowing the distance between the laminar elements in question to be adjusted such that adjacent laminar elements may be positioned very close to each other regardless of their length. Said assembly comprises an insertion device (1) that includes a rotating belt system on which the laminar elements (3) can be moved horizontally, and suction means, with the insertion device (1) connected to a stacking area (4) and; a pulling device (2) that includes a rotating belt system on which the laminar elements from the insertion device (1) can be moved, and suction means, with the pulling device (2) connected to a graphic printing station, said pulling device adjoining the insertion device (1) in a direction of forward motion.

Abstract: A method for feeding laminar elements into an introducer associated with a graphic printing station provided for printing at least one of the faces of the laminar element, wherein a plurality of laminar elements are grouped in an orderly manner in a stacked group of laminar elements that extends upwards, such that the longitudinal axis of each of the laminar elements is located perpendicular with respect to an advance direction of the group, the advance direction of the group being perpendicular to the advance direction of the introducer. This group of laminar elements is turned 180 degrees with respect to a rotation axis that is parallel to the advance direction of the introducer, such that the upper face of each one of the laminar elements is oriented downwards, the turned laminar element advancing in a direction perpendicular to the advance direction of the introducer.

Abstract: The invention relates to a cutting machine for cutting cardboard, paper or the like, comprising an aligning station having a horizontal bedplate provided with sheet shifting means and stop means arranged along the forward movement direction of the sheet and configured for being in contact with one of the sides of the sheet for guiding the movement for shifting the sheet. Additionally, the machine comprises a cutting station provided with cutting means arranged in a transverse direction with respect to the forward movement direction of the sheets for dividing the sheets into longitudinal sections, and sheet shifting means for shifting the sheets in the forward movement direction which coincides with a longitudinal axis of the cutting station, said cutting means being provided for dividing each sheet into portions, a longitudinal axis of the bedplate of the aligning station having, when seen in plan view, an angle of inclination with respect to the longitudinal axis of the cutting station.

Abstract: An insertion assembly for the continuous and automated feeding of laminar elements into a graphic printing station without the involvement of roller elements in the process, allowing the distance between the laminar elements in question to be adjusted such that adjacent laminar elements may be positioned very close to each other regardless of their length. Said assembly comprises an insertion device (1) that includes a rotating belt system on which the laminar elements (3) can be moved horizontally, and suction means, with the insertion device (1) connected to a stacking area (4) and; a pulling device (2) that includes a rotating belt system on which the laminar elements from the insertion device (1) can be moved, and suction means, with the pulling device (2) connected to a graphic printing station, said pulling device adjoining the insertion device (1) in a direction of forward motion.

Abstract: System for handling dies with a rectangular and/or arched transverse cross-section that comprises a support for placing in a removable manner dies having a rectangular transverse cross-section, the support being designed to be coupled in a sliding manner to a fixed structure, in which at least said support has fastening means for holding at least one die with a rectangular transverse cross-section vertically in the air; and a handler provided with hooking means designed to be coupled to the support to place and/or remove the support with respect to the fixed structure, the handler having coupling means to be coupled to a transelevator or similar. This system is designed to facilitate the operations of placing and removing the dies during their storage.

Abstract: The apparatus has a containing body with a flat upper functional floor for containing receptacles of reagents, diluents and samples, as well as housings for gel cards and incubators for the same; a lower floor containing receptacles for washing liquids and the collection of waste and cards and for housing the fluid control and electronic control system; a series of longitudinal and transverse guides associated with the upper part of the apparatus, suitable for carrying in suspension the moving heads of the apparatus, the heads being movable on the transverse guides; two heads, respectively for perforation and pipetting and for the transport of gel cards; two centrifuges and a gel card reader; and a folding touch screen providing information and control.

Abstract: The present invention relates to a method for controlling the operation of a printing press and a flexographic printing press for implementing said method, wherein the method comprises performing the following steps: a) capturing information from at least one image printed by said printing press; and b) comparing said information captured from said printed image with at least some digital-format information predetermined in prepress, or digital prepress information, including at least one part of the image to be printed. The method comprises adjusting the pressure and/or register setting of one or more printing units of the printing press, using at least the result of the comparison in said step b). The press is designed in order to implement the method.

Abstract: Printing facility for the manipulation of a plurality of sleeve assemblies (52) each composed by a printing sleeve (50) having a cylindrical internal surface (61) with a diameter larger than the diameter of a printing shaft (12) and an independent tubular cylindrical intermediate sleeve (51) inserted into the cylindrical printing sleeve (50), said printing sleeve comprising a printing machine (10) comprising cylindrical printing shafts (12), and a robotic unit (20) comprising a sleeves handling device (21), the facility further comprising a first storage (30) for store a plurality of printing sleeves (50), which include retaining elements (31) for the immobilization of the stored printing sleeves (50) in geometrical interference with the printing cylindrical external surface (60) and/or with at least one of the annular faces (62) of the printing sleeves (50).

Abstract: System for handling dies with a rectangular and/or arched transverse cross-section that comprises a support for placing in a removable manner dies having a rectangular transverse cross-section, the support being designed to be coupled in a sliding manner to a fixed structure, in which at least said support has fastening means for holding at least one die with a rectangular transverse cross-section vertically in the air; and a handler provided with hooking means designed to be coupled to the support to place and/or remove the support with respect to the fixed structure, the handler having coupling means to be coupled to a transelevator or similar. This system is designed to facilitate the operations of placing and removing the dies during their storage.