Patents by Inventor Jorg Berghausen

Jorg Berghausen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Patent number: 8236960
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: August 7, 2012
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its Tartrate Salt and Crystalline Forms
    Publication number: 20110184179
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: April 6, 2011
    Publication date: July 28, 2011
    Inventors: Mikkel Boas THYGESEN, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Patent number: 7923564
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: April 12, 2011
    Assignee: ACADIA Pharmaceuticals, Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-y1)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
    Patent number: 7868176
    Abstract: Disclosed herein are salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy) phenylmethyl)carbamide including the citrate, fumarate, maleate, malate, phosphate, succinate, sulphate, and edisylate salts.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: January 11, 2011
    Assignee: ACADIA Pharmaceuticals, Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Fritz Blatter, Jörg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its Tartrate Salt and Crystalline Forms
    Publication number: 20100305329
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: June 7, 2010
    Publication date: December 2, 2010
    Inventors: Mikkel Boas THYGESEN, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jorg Berghausen
  • Crystalline forms of Rizatriptan benzoate
    Patent number: 7777049
    Abstract: The present invention is directed to the novel polymorphic Form A and Form B of Rizatriptan benzoate, processes for the preparation thereof and pharmaceutical compositions comprising these crystalline forms.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: August 17, 2010
    Assignee: ratiopharm GmbH
    Inventors: Paul Adriaan Van Der Schaaf, Jörg Berghausen, Fritz Blatter, Martin Szelagiewicz, Ulrich Berens
  • N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Patent number: 7732615
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: June 8, 2010
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Mikkel Boas Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus A. Andersson, Fritz Blatter, Jörg Berghausen
  • Crystalline Forms of Rizatriptan Benzoate
    Publication number: 20080249149
    Abstract: The present invention is directed to the novel polymorphic Form A and Form B of Rizatriptan benzoate, processes for the preparation thereof and pharmaceutical compositions comprising these crystalline forms.
    Type: Application
    Filed: January 5, 2005
    Publication date: October 9, 2008
    Inventors: Paul Adriaan Van Der Schaaf, Jorg Berghausen, Fritz Blatter, Martin Szelagiewicz, Ulrich Berens
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060205781
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20060205714
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jorg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060205780
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 14, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20060199808
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 7, 2006
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jorg Berghausen
  • Salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation
    Publication number: 20060111399
    Abstract: Disclosed herein are salts of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide including the citrate, fumarate, maleate, malate, phosphate, succinate, sulphate, and edisylate salts.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 25, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Fritz Blatter, Jorg Berghausen
  • Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
    Publication number: 20060106063
    Abstract: Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 18, 2006
    Inventors: Mikkel Thygesen, Nathalie Schlienger, Bo-Ragnar Tolf, Carl-Magnus Andersson, Fritz Blatter, Jorg Berghausen
  • Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
    Publication number: 20050282800
    Abstract: Disclosed herein are crystalline Forms A, B, C, D, and E of N-desmethylclozapine, methods of preparing the same, pharmaceutical compositions comprising the same, and methods of therapeutic treatment involving N-desmethylclozapine polymorphic forms.
    Type: Application
    Filed: March 31, 2005
    Publication date: December 22, 2005
    Inventors: Bo-Ragnar Tolf, Mikkel Thygesen, Fritz Blatter, Jörg Berghausen