Abstract: A test system for characterizing the compatibility of bioactive substances with polyvinylpyrrolidones in a solid dispersion consisting of one or more bioactive substances and 1,3-bis(1-pyrrolidonyl)butane.

Abstract: Solvent-free noncrystalline bioactive substances are prepared from the corresponding crystalline bioactive substances in an extruder by melting the substances in the extruder under reduced pressure and in the absence of auxiliaries, cooling and comminuting.

Abstract: The present invention relates to an apparatus for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one polymeric binder. The apparatus according to the invention has at least one extruder 1 for continuous plastication of the formulation and at least two injection units 2 which are provided separate from one another, each of which is connected to the extruder 1, and through which the formulation can be injected into at least one mold 3.

Abstract: The present invention relates to a 1,3-bis-(N-lactamyl)propane of general formula (I), wherein radicals R1, R2, R3, R4, R5 and R6 independently stand for hydrogen, alkyl, cycloalkyl, aryl or aralkyl and at least one of said radicals does not stand for hydrogen, (NLac) and (NLac′) are the same or different and stand for N-lactamyl radicals. The invention also relates to the use of said substances as a solvent in pharmaceutical and cosmetic agents. Disclosed are novel compounds of formula (I), wherein R1 and methyl and R2-R6 stand for hydrogen.

Abstract: A formulation based i) on lipoic acid or a physiologically acceptable salt thereof and, where appropriate, other active substances, and a formulation base having ii) a binder component and iii) where appropriate other physiologically acceptable excipients is described. Lipoic acid is in the form of a molecular dispersion in these formulations. An advantageous process for their preparation, in particular by melt extrusion, and the use of this formulation for oral administration of lipoic acid are likewise described.

Abstract: A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.

Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.

Abstract: The invention relates to a process for producing coated solid dosage forms by forming a plastic mixture from at least one thermoplastic physiologically tolerated polymeric binder and at least one active ingredient and extruding the plastic mixture, wherein the extrudate is subsequently treated with at least one liquid or vaporized coating agent, and the coated extrudate is shaped to the required dosage form.

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

Abstract: A process for producing solid creatine-containing dosage forms, wherein

Abstract: A process for preparing liquid iodophores with poly-N-vinyllactams and dextrins as carrier materials, which comprises heating a mixture of the carrier materials, iodine and iodide ions or, in place of the iodide ions, a reducing agent in aqueous medium in the presence of a monohydric or polyhydric alcohol having 1 to 6 carbon atoms at from 40 to 100° C.

Abstract: A process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, in a screw extruder divided into a plurality of zones, wherein there is firstly melting of the matrix auxiliaries and mixing of the bioactive components with the matrix auxiliaries in a heatable zone, after which the mixture is cooled, precomminuted and finely ground in a cooling zone, the screw geometry in the cooling zone being selected so that the cooling zone consists of a conveying zone, a mixing zone and a kneading zone.

Abstract: Polymer powders redispersible in aqueous solution, their use in cosmetic, pharmaceutical or crop protection formulations and a process for preparing polymer powders redispersible in aqueous solution comprising copolymers carrying free acid or base groups and, if appropriate, auxiliaries, which comprises adjusting the pH of the dispersion prior to drying by the addition of at least one buffer system to a pH of from 2.0 to 6.5 in the case of copolymers carrying free acid groups or a pH of from pH 7.5 to 12 in the case of copolymers carrying free base groups.

Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture of a) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30, b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, and c) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium, where the stated amounts are based on the total of components a), b) and c).

Abstract: The present invention relates to topical products intended for use as prophylactic or curative agents for bacterial skin infections, containing at least one polymeric complex substantially consisting of hydrogen peroxide, a suitable polymer for the complex formation thereof, possibly another bactericidal compound and possibly a metal salt or a metal colloid.

Abstract: A process for producing solid dose forms by mixing at least one polymeric binder, with or without at least one active ingredient and with or without conventional additives, and shaping the mixture, where at least one of the components is employed in liquid form.

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients, A) 10-90% by weight of a melt-processable, water-soluble polymer, B) 5-85% by weight of isomalt, and C) 0-5% by weight of lecithin, where the total of all the ingredients is to be equal to 100% by weight.

Abstract: Complexes in powder form of iodine and a crosslinked polymer based on N-vinyl compounds are obtainable by dry heating of iodine and a polymer which is obtained by polymerization of monovinyl compounds (monomers A) whose vinyl group is bonded to a nitrogen atom of a nitrogen-containing heterocycle, in the presence of from 0.5 to 10% by weight, based on the monomers (A), of a compound (B) of the formula I; where A is —CH— or a nitrogen atom, and n is 2 or 3. The complexes are suitable for producing antidiarrheals.

Abstract: Solid foamed active ingredient preparations based on melt-processable polymers, obtainable by extrusion of a melt of one or more polymers which comprises active ingredient and which is impregnated with a volatile, physiologically acceptable blowing agent and expanded.