Abstract: This invention relates to the field of the detection of prion diseases. The invention provides a binding molecule or antibody specifically reactive with an epitope which is exposed on a part of an aberrant conformer (PrPSc) of a prion protein after treatment of said conformer with a protease wherein said epitope is not or only partly exposed on a prion protein which has not been treated with a protease.

Abstract: The above described apparatus and methods provide the possibility to reduce or even eliminate the effects of delay between image acquisition and laser ablation. Thus this will lead to less positioning errors and therefore to better ablation results in laser refractive surgery. The importance of this invention will increase with decreasing ablating beam diameter. The use of synchronization leads to shorter delay times. Hence it follows that the duration of the whole treatment decreases as well.