Patents by Inventor Jorg Keldenich

Jorg Keldenich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors, for treatment of hypertension
    Patent number: 7314871
    Abstract: The application claims a method for treating hypertension by administering an effective amount of a compound of the formula (I) wherein the variable groups are as defined in the specification and claims. These 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: January 1, 2008
    Assignee: Bayer Aktiengesellschaft
    Inventors: Maria Niewöhner, legal representative, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski, Ulrich Niewöhner, deceased
  • Substituted Dihydroquinazolines II
    Publication number: 20070281953
    Abstract: The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.
    Type: Application
    Filed: October 28, 2004
    Publication date: December 6, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Peter Nell, Susanne Nikolic, Frank Sussmeier, Holger Zimmermann, Rolf Grosser, Guy Hewlett, Jorg Keldenich, Dieter Lang, Kerstin Henninger
  • Substituted dihydroquinazolines
    Publication number: 20070191387
    Abstract: The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
    Type: Application
    Filed: March 26, 2007
    Publication date: August 16, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Thomas Lampe, Susanne Nikolic, Jurgen Reefschlager, Rudolf Schohe-Loop, Frank Sussmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Dieter Lang, Peter Nell
  • Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents
    Publication number: 20070185121
    Abstract: The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.
    Type: Application
    Filed: April 28, 2004
    Publication date: August 9, 2007
    Applicant: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Peter Nell, Susanne Nikolic, Frank Sussmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Dieter Lang
  • Dihydropyridine derivatives for use as human neutrophil elastase inhibitors
    Publication number: 20070167406
    Abstract: The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
    Type: Application
    Filed: August 18, 2003
    Publication date: July 19, 2007
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schiemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenich, Mary Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer
  • Dihydropyridinone derivatives
    Patent number: 7230017
    Abstract: The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: June 12, 2007
    Assignee: Bayer Healthcare AG
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schlemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenich, Mary F. Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer
  • Substituted imidazotriazines
    Patent number: 7202243
    Abstract: The invention relates to new substituted imidazotriazines, processes for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative disorders, in particular of Parkinson's disease and of schizophrenia.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: April 10, 2007
    Assignee: Bayer HealthCare AG
    Inventors: Martin Hendrix, David Brückner, Arno Friedl, Irene Gerlach, Volker Hinz, Jörg Keldenich, Frank Mauler, Maria Niewöhner, legal representative, Dagmar Karthaus, Karl-Heinz Schlemmer, Adrian Tersteegen, Özkan Yalkinoglu, Ulrich Niewöhner, deceased
  • Substituted dihydroquinazolines
    Patent number: 7196086
    Abstract: The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: March 27, 2007
    Assignee: Bayer HealthCare AG
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Thomas Lampe, Susanne Nikolic, Jürgen Reefschläger, Rudolf Schohe-Loop, Frank Süssmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jörg Keldenich, Dieter Lang, Peter Nell
  • 2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses
    Publication number: 20070066622
    Abstract: The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
    Type: Application
    Filed: January 29, 2004
    Publication date: March 22, 2007
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Gerald Kleymann, Thomas Lampe, Susanne Nikolic, Jurgen Reefshlager, Rudolf Schohe-Loop, Frank Submeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Thomas Kramer, Peter Nell, Tse-I Lin
  • Method for inhibiting the replication of herpes viruses
    Publication number: 20070004735
    Abstract: The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.
    Type: Application
    Filed: December 24, 2003
    Publication date: January 4, 2007
    Inventors: Ulrich Betz, Guy Hewlett, Gerald Kleymann, Thomas Lampe, Tse-I Lin, Susanne Nikolic, Jurgen Reefshlager, Tobias Wunberg, Holger Zimmerman, Franz Zumpe, Wolfgang Bender, Kerstin Henninger, Axel Jensen, Jorg Keldenich, Rudolf Schohe-Loop
  • Substituted quinazolines as antiviral agents, especially against cytomegaloviruses
    Publication number: 20060235032
    Abstract: The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
    Type: Application
    Filed: October 25, 2003
    Publication date: October 19, 2006
    Inventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Susanne Nikolic, Frank Submeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Dieter Lang, Tse-I Lin
  • 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Patent number: 7122540
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: October 17, 2006
    Assignee: Bayer HealthCare AG
    Inventors: Maria Niewöhner, legal representative, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Semo, Marc Nowakowski, Ulrich Niewöhner, deceased
  • Hetrocyclic aryl sulphonamides
    Patent number: 7115636
    Abstract: The invention relates to novel sulfonamides of general formula (I) where the substituents R1, R2, R3, R4, A and X have the given meanings, pharmaceutical compositions containing them, and a method of using them as antiviral agents, in particular against cytomegaloviruses.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: October 3, 2006
    Assignee: Bayer Healthcare AG
    Inventors: Tobias Wunberg, Wolfgang Bender, Peter Eckenberg, Sabine Hallenberger, Kerstin Henninger, Jörg Keldenich, Armin Kern, Siegfried Raddatz, Jürgen Reefschläger, Gunter Schmidt, Holger Zimmermann, Franz Zumpe, Martin Radtke
  • Arylsulfonamides as antiviral agents
    Patent number: 7115612
    Abstract: The present invention relates to novel sulphonamides of the general formula (I) in which the substituents R1, R2, R3, R4 and A and X are as defined in claim 1 and other claims, and also to processes for their preparation and to their use as antiviral agents, in particular against cytomegaloviruses.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: October 3, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Tobias Wunberg, Wolfgang Bender, Peter Eckenberg, Sabine Hallenberger, Kerstin Henninger, Jörg Keldenich, Armin Kern, Siegfried Raddatz, Jürgen Reefschläger, Gunter Schmidt, Holger Zimmermann, Franz Zumpe, Martin Radtke
  • Thiazolyl amide derivatives
    Patent number: 7105553
    Abstract: The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: September 12, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rüdiger Fischer, Gerald Kleymann, Ulrich Betz, Judith Baumeister, Wolfgang Bender, Peter Eckenberg, Gabriele Handke, Martin Hendrix, Kerstin Henninger, Axel Jensen, Jörg Keldenich, Udo Schneider, Olaf Weber
  • 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Publication number: 20060189615
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Application
    Filed: April 21, 2006
    Publication date: August 24, 2006
    Applicant: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jorg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Biphenyl and biphenyl-analogous compounds as integrin antagonists
    Patent number: 7094911
    Abstract: The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have the formula (1) wherein R1, R2, U, V, A, B, W, R3, C and R4 have the meaning as defined in the claims.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: August 22, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Markus Albers, Klaus Urbahns, Andrea Vaupel, Michael Härter, Delf Schmidt, Beatrix Stelte-Ludwig, Christoph Gerdes, Elke Stahl, Jörg Keldenich, Ulf Brueggemeier, Klemens Lustig
  • Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
    Publication number: 20060183753
    Abstract: The present invention relates to the use of 2,5-diamidoindole derivatives for the preparation of medicaments for treating urological disorders in humans and/or animals.
    Type: Application
    Filed: December 6, 2003
    Publication date: August 17, 2006
    Applicant: Bayer HealthCare AG
    Inventors: Jens Erguden, Thomas Krahn, Christian Schroder, Johannes Stasch, Stefan Weigand, Hanno Wild, Michael Brands, Stehan Siegel, Dirk Heimbach, Jorg Keldenich, Masaomi Tajimi, Hiroko Takagi
  • Substituted imidazotriazines
    Publication number: 20060166993
    Abstract: The invention relates to new substituted imidazotriazines, processes for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative disorders, in particular of Parkinson's disease and of schizophrenia.
    Type: Application
    Filed: June 25, 2003
    Publication date: July 27, 2006
    Applicant: Bayer Healthcare AG
    Inventors: Martin Hendrix, David Bruckner, Arno Friedl, Irene Gerlach, Volker Hinz, Jorg Keldenich, Frank Mauler, Ulrich Niewohner, Maria Niewohner, Dagmar Karthaus, Karl-Heinz Schlemmer, Adrian Tersteegen, Ozkan Yalkinoglu
  • Heterocyclically substituted imidazotriazines
    Publication number: 20060166992
    Abstract: The invention relates to new heterocyclically substituted imidazotriazines, processes for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative disorders, in particular of Parkinson's disease and of schizophrenia.
    Type: Application
    Filed: June 25, 2003
    Publication date: July 27, 2006
    Applicant: Bayer Healthcare A G
    Inventors: Martin Hendrix, David Bruckner, Arno Friedl, Irene Gerlach, Volker Hinz, Jorg Keldenich, Frank Mauler, Ulrich Niewohner, Maria Niewohner, Dagmar Karthaus, Karl-Heinz Schlemmer, Adrian Tersteeger, Ozkan Yalkinoglu