Patents by Inventor JORG KLEIBER
JORG KLEIBER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120022246Abstract: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.Type: ApplicationFiled: October 7, 2011Publication date: January 26, 2012Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Jorg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Publication number: 20110117561Abstract: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.Type: ApplicationFiled: November 30, 2010Publication date: May 19, 2011Applicant: ROCHE DIAGNOSTICS GMBHInventors: Jörg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Patent number: 7371830Abstract: Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 ?m. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.Type: GrantFiled: January 24, 2005Date of Patent: May 13, 2008Assignee: Roche Diagnostics GmbHInventors: Jörg Kleiber, Thomas Walter, Herbert Harttig, Christop Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Publication number: 20070082360Abstract: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.Type: ApplicationFiled: December 12, 2006Publication date: April 12, 2007Inventors: Jorg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Patent number: 7125972Abstract: A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex problematic cases.Type: GrantFiled: August 29, 2002Date of Patent: October 24, 2006Assignee: Boston Probes, Inc.Inventors: Jörg Kleiber, Henrik Ørum, Ane-Ullerup Lester, Albert Geiger
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Publication number: 20050266429Abstract: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.Type: ApplicationFiled: January 24, 2005Publication date: December 1, 2005Inventors: Jorg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Patent number: 6870047Abstract: Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free class surface or having pores with a diameter offices than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 ?m. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.Type: GrantFiled: January 10, 2001Date of Patent: March 22, 2005Assignee: Roche Diagnostics GmbHInventors: Jörg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Publication number: 20030199078Abstract: The invention concerns a process for preparing biological samples for the subsequent detection of an analyte. In particular, the invention relates to a process for the isolation of a nucleic acid in a sample using a suspension of magnetic glass particles. In addition, kits and apparatuses containing magnetic glass particles for sample preparation are provided.Type: ApplicationFiled: April 30, 2003Publication date: October 23, 2003Inventors: Jorg Kleiber, Christine Markert-Hahn, Herbert Harttig
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Publication number: 20030135038Abstract: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.Type: ApplicationFiled: July 23, 2002Publication date: July 17, 2003Applicant: Roche Diagnostics GmbH.Inventors: Jorg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lensniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Publication number: 20030099986Abstract: A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex problematic cases.Type: ApplicationFiled: August 29, 2002Publication date: May 29, 2003Applicant: Boston Probes, Inc.Inventors: Jorg Kleiber, Henrik Orum, Ane-Ullerup Lester, Albert Geiger
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Patent number: 6562568Abstract: The invention concerns a process for preparing biological samples for the subsequent detection of an analyte. In particular, the invention relates to a process for the isolation of a nucleic acid in a sample using a suspension of magnetic glass particles. In addition, kits and apparatuses containing magnetic glass particles for sample preparation are provided.Type: GrantFiled: September 5, 2000Date of Patent: May 13, 2003Assignee: Roche Diagnostics GmbHInventors: Jörg Kleiber, Christine Markert-Hahn, Herbert Harttig
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Patent number: 6475721Abstract: A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex problematic cases.Type: GrantFiled: November 12, 1997Date of Patent: November 5, 2002Assignee: Boston Probes, Inc.Inventors: Jörg Kleiber, Henrik Ørum, Ane-Ullerup Lester, Albert Geiger
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Publication number: 20020137920Abstract: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.Type: ApplicationFiled: January 10, 2001Publication date: September 26, 2002Applicant: Boehringer Mannheim GmbH.Inventors: Jorg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt
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Patent number: 6270965Abstract: The present invention concerns a method and a device which enables an integrated amplification and detection of nucleic acids.Type: GrantFiled: July 15, 1998Date of Patent: August 7, 2001Assignee: Roche Diagnostics, GmbHInventors: Jörg Kleiber, Karim Tabiti, Gregor Sagner
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Publication number: 20010010902Abstract: A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex problematic cases.Type: ApplicationFiled: November 12, 1997Publication date: August 2, 2001Inventors: JORG KLEIBER, HENRIK ORUM, ANE-ULLERUP LESTER, ALBERT GEIGER
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Patent number: 6255477Abstract: Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 &mgr;m and any pores of the glass surface have a diameter of less than 10 nm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.Type: GrantFiled: March 11, 1998Date of Patent: July 3, 2001Assignee: Roche Diagnostics GmbHInventors: Jörg Kleiber, Thomas Walter, Herbert Harttig, Christoph Lesniak, Martin Mennig, Michael Riedling, Helmut Schmidt