Patents by Inventor Jorg Kreuter
Jorg Kreuter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110293730Abstract: A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles.Type: ApplicationFiled: July 20, 2011Publication date: December 1, 2011Applicant: LTS Lohmann Therapie-Systeme AGInventors: Jörg Kreuter, Svetlana Gelperina, Olga Maksimenko, Alexander Khalanskiy
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Patent number: 8003128Abstract: A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles.Type: GrantFiled: March 13, 2007Date of Patent: August 23, 2011Assignee: LTS Lohmann Therapie-Systeme AGInventors: Jörg Kreuter, Svetlana Gelperina, Olga Maksimenko, Alexander Khalanskiy
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Publication number: 20100028446Abstract: Combination preparations comprising at least one apolipoprotein as one component, and a medicinal agent to be transported via the blood-brain barrier to the central nervous system as a further component. The components are administered simultaneously, separately or sequentially. A method for administering a medicinal agent to the central nervous system is also provided.Type: ApplicationFiled: February 1, 2008Publication date: February 4, 2010Inventors: Jörg Kreuter, Klaus Langer, Sebastian Dreis, Telli Hekmatara
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Publication number: 20090304720Abstract: Active agent-loaded nanoparticles that are based on a hydrophilic protein or a combination of hydrophilic proteins, and methods for producing the nanoparticles and the use thereof. Functional proteins or peptide fragments are bound to the nanoparticles via polyethylene glycol-?-maleimide-?-NHS esters.Type: ApplicationFiled: February 27, 2007Publication date: December 10, 2009Applicant: LTS Lohmann Therapie-Systeme AGInventors: Jörg Kreuter, Klaus Langer, Kerstin Michaelis, Telli Hekmatara, Sebastian Dreis
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Publication number: 20090263491Abstract: A drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across the animal's blood brain barrier. The drug targeting system comprises nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), a pharmacologically active substance which is absorbed to, adsorbed to, and/or incorporated into the nanoparticles, and either contains TPGS or comprises a pluronic 188 surfactant coating deposited on the drug-loaded nanoparticles.Type: ApplicationFiled: March 13, 2007Publication date: October 22, 2009Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Jorg Kreuter, Svetlana Gelperina, Olga Maksimenko, Alexander Khalanskiy
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Publication number: 20090181090Abstract: Nanoparticles, the particle matrix of which is based on at least one protein and has at least one active agent embedded therein and methods of producing the nanoparticles with at least one active agent embedded in the protein matrix are disclosed. The use of the nanoparticles for the treatment of tumours, in particular for the treatment of tumours which are resistant to chemical medicaments is also disclosed.Type: ApplicationFiled: December 22, 2006Publication date: July 16, 2009Inventors: Sebastian Dreis, Klaus Langer, Jörg Kreuter, Martin Michaelis, Jindrich Cinatl
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Publication number: 20080095857Abstract: A carrier system in the form of protein-based nanoparticles for the cell-specific, intracellular enrichment of at least one pharmacologically active substance. The system has structures that are coupled by reactive groups. The structures enable a cell-specific attachment and cellular absorption of the nanoparticles.Type: ApplicationFiled: March 2, 2005Publication date: April 24, 2008Applicant: LTS LOHMANN THERAPIE-SYSTEME AG LOHMANNSTRASSE 2Inventors: Sabine Balthasar, Hagen Von Briesen, Norbert Dinauer, Jorg Kreuter, Klaus Langer, Heidrun Wartlick
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Publication number: 20030032601Abstract: The invention relates to a method for the simplified isolation in high yields of sponge collagen, especially from marine sponges, and to the production of collagen nanoparticles from collagen. The invention further relates to the use thereof for influencing cell-dependent processes in vitro and in vivo, especially when orally or topically administered to treat inflammatory, preferably cyclooxygenase-dependent diseases.Type: ApplicationFiled: August 23, 2002Publication date: February 13, 2003Inventors: Jorg Kreuter, Werner Muller, Dieter Swatschek, Wolfgang Schatton, Maria Schatton
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Patent number: 6288040Abstract: The invention relates to medicament excipient particles which are suitable for tissue-specific application of a medicament, especially to the central nervous system (CNS). The invention particles can be loaded with or be free pf the active substance. At least one detection protein is bonded to the particle surface or alternatively, the particle surface is modified in such a way that a detection protein bonds with it on contact.Type: GrantFiled: June 21, 2000Date of Patent: September 11, 2001Assignee: DSS Drug Delivery Service Gesellschaft zur Forderung der Foshung In Phamazeutischer Technologi und Biopharmazie mbHInventors: Ranier H. Müller, Martin Lück, Jörg Kreuter
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Patent number: 6165988Abstract: The medicament in particulate form has one or more anionic or partially anionic active substances bound to a carrier material. The carrier material includes particulate copolymer or homopolymer of acrylic acid or acrylic acid ester or methacrylic acid esters. The carrier further includes oxygen in the ester group, a branched or unbranched alkyl chain with 2-10 carbon atoms, --NR.sub.2 where R represents H and lower alkyl chains in any combination, and H or a lower alkyl chain. The grain size distribution of the carrier is 10-1000 nm.Type: GrantFiled: August 11, 1997Date of Patent: December 26, 2000Assignees: Christian Noe, Joerg KreuterInventors: Christian Noe, Jorg Kreuter, Andreas Zimmer, Hans-Peter Zobel, Frank Stieneker, Serap Atmaca-Abdel Aziz
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Patent number: 6117454Abstract: A novel method of delivering drugs and diagnostics across the blood-brain barrier or blood-nerve barrier is disclosed. Drugs or diagnostic agents are incorporated into nanoparticles which have been fabricated in conventional ways. These nanoparticles are then coated with additional surfactant and given to the body of animals or humans. This allows drugs or diagnostic agents to cross the blood-brain barrier (bbb) to achieve one or more of the following benefits: (1) reducing the dose of a therapeutic drug or diagnostic agent which, when given peripherally, maintains the biological or diagnostic potency in the nervous system, (2) allowing drugs that normally do not cross the bbb to penetrate into the nervous system, and (3) reducing the peripheral side effects by increasing the relative amount of the drug reaching the brain.Type: GrantFiled: May 27, 1997Date of Patent: September 12, 2000Assignee: Medinova Medical Consulting GmbHInventors: Jorg Kreuter, Renad N. Alyautdin, Dimitri A. Karkevich, Bernhard A. Sabel
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Patent number: 4269821Abstract: There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbing the biologically active material upon preformed submicroscopic polymer particles. Where the biologically active material is an antigen, the particles are useful as constituents of injectable vaccines having an adjuvant effect.Type: GrantFiled: May 2, 1980Date of Patent: May 26, 1981Assignees: Jorg Kreuter, Peter Paul SpeiserInventors: Jorg Kreuter, Peter P. Speiser
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Patent number: 4225581Abstract: There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbing the biologically active material upon preformed submicroscopic polymer particles. Where the biologically active material is an antigen, the particles are useful as constituents of injectable vaccines having an adjuvant effect.Type: GrantFiled: August 7, 1978Date of Patent: September 30, 1980Assignees: Jorg Kreuter, Peter Paul SpeiserInventors: Jorg Kreuter, Peter P. Speiser