Abstract: A rotatable sphincterotome/papillotome is inserted into a flexible endoscope and is used for orienting the distal cutting wire tip of the rotatable sphincterotome/papillotome in a twelve o'clock position, where the distal cutting wire tip cuts the sphincter muscle of a patient. The sphincterotome has a housing and a flexible tubular member protruding from the housing. A slidable member is slidably connected on the housing for moving the distal cutting wire tip in a longitudinal direction to cut the sphincter muscle. A ratchet mechanism is rotatably attached to the housing for orienting the angle of the distal cutting wire tip to a correct cutting position, where the gripping assembly is rotatable on the ratchet mechanism. To change the angle of the distal cutting wire tip of the sphincterotome, a user must use one hand to hold the ratchet mechanism while the other hand rotates the housing, and thereby the angle of the distal cutting wire tip changes to a specific degree.