Abstract: New 8-substituted 2-aminotetralins can be prepared from the corresponding aminotetralins or tetralones. They can be used in medicaments.

Abstract: The invention relates to combination products with a synergistic action and antidepressant activity, containing substances having antidepressant activity and compounds having antagonistic activity and belonging to the class of dihydropyridines, and to the use of the dihydropyridines in antidepressants.

Abstract: The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.

Abstract: A method of treating a patient afflicted with alcohol addiction which comprises administering to such patient an amount effective therefor of a dihydropyridine of the formula ##STR1## in which R.sup.1 is one or two substituents independently selected from the group consisting of nitro, halogen, trifluoromethyl and OCHF.sub.2,R.sup.2 and R.sup.3 each independently is alkyl with 1 to 12 carbon atoms optionally substituted by alkoxy with 1 to 4 C atoms, hydroxyl, halogen or N-methyl-N-benzylamino, andR.sup.4 is cyano or alkyl with 1 to 4 carbon atoms optionally substituted by hydroxyl or halogen.

Abstract: A method for the treatment of alcoholism and medicaments used for such treatment wherein patients receive an effective amount of a 2-pyrimidinyl-1-piperazine derivative of the formula ##STR1## in which n represents one of the numbers 2, 3, 4, 5 or 6, andR represents ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 each independently denote hydrogen or lower alkyl, or salts thereof.

Abstract: For treatment of disorders of the central nervous system, the cardiovascular system or the intestinal tract, the new substituted basic 2-aminotetralins of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen, alkyl or acyl, andR.sup.3 represents quinuclidine or a group of the formula --(CH.sub.2).sub.a --R.sup.4, --CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.b --R.sup.4, --CH.sub.2 --C.tbd.(CH.sub.2).sub.b --R.sup.4, ##STR2## wherein a denotes a number from 1 to 10,b denotes a number 0, 1, 2, 3 or 4,d denotes a number 2 or 3, andX denotes oxygen, sulphur, or NR.sup.5,and their salts.

Abstract: New 8-substituted 2-aminotetralins can be prepared from the corresponding aminotetralins or tetralones. They can be used in medicaments.

Abstract: A method of treating warm-blooded animals to reduce their dependency upon nicotine comprising administering to such animals a medicament containing a 2-pyrimidinyl-1-piperazine derivative of the formula ##STR1## in which n stands for 2, 3, 4, 5 or 6 and R stands for ##STR2##

Abstract: Novel tryptamines of the formula ##STR1## in which X is an alkylene chain or 2 to 4 carbon atoms wherein a carbon atom may be replaced by O or N-lower alkyl, and wherein a carbon atoms may be substituted by lower alkyl,R is hydrogen, lower alkyl, lower alkoxy, phenyl-lower alkyl, phenyl-lower alkoxy, hydroxy, amino-lower alkyl, fluorine, chlorine, bromine, cyano, carbamoyl or azido,R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each independently is hydrogen or lower alkyl,R.sup.5 is hydrogen, R.sup.6 --CO-- or R.sup.6 --SO.sub.2 --, andR.sup.6 is amino, lower alkoxy, phenyl or lower alkyl-phenyl,or dimers or salts thereof, are effective in treating disorders of the central nervous system.

Abstract: The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.

Abstract: The present invention relates to novel benzodiazepines, acid addition salts thereof, processes for their preparation and their use in combating diseases, in particular for the treatment of cerebral disorders caused by old age and for the treatment of disorders in learning and memory and amnesia.

Abstract: Pyridoindoles of the formula ##STR1## in which R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 -alkyl, which is optionally substituted by the radical ##STR2## R.sub.2 and R.sub.3 represent H or form a bond, or R.sub.1 and R.sub.2 together represent O, --O--CH.sub.2 --CH.sub.2 --O-- or --S--CH.sub.2 --CH.sub.2 --S--,R.sub.4 represents H or the ##STR3## or R.sub.3 and R.sub.4 represent O, orR.sub.1 and R.sub.4 are members of an N-containing six-membered ring andR.sub.8 and R.sub.9 represent H or C.sub.1 -C.sub.4 -alkyl, or optionally form, with the N atom, a heterocyclic 5-membered or 6-membered ring, which can optionally also contain a further hetero-atom from the series comprising N, O or S,R.sub.5 represents H, C.sub.1 -C.sub.4 -alkyl or the group ##STR4## or R.sub.5 and R.sub.3 form a bond, andR.sub.10 and R.sub.11 represent C.sub.1 -C.sub.4 -alkyl or are members of an N-containing 5-membered or 6-membered ring,R.sub.6 represents H or C.sub.1 -C.sub.4 -alkyl andR.sub.