Abstract: Pharmaceutical composition comprising growth-hormone releasing peptide 6 (GHRP-6), tartrate buffer at pH 5.0-6.0, and trehalose as stabilizing agent, as well as the use of said composition for the manufacture of a medicament. The invention also provides a kit of parts comprising said pharmaceutical composition and a method of treatment of an individual in need thereof, which entails the administration of a therapeutically effective amount of the pharmaceutical composition comprising of GHRP-6, tartrate buffer at pH 5.0-6.0 and trehalose.

Abstract: Multiple layers of a seal can be formed to pressure-seal an open-hole wellbore in a subterranean formation. The seal can include at least one element and a sealing mixture between the element and a container housing for pressure sealing the open-hole wellbore between the element and the container housing and for providing multiple layers of seal in the open-hole wellbore. The seal can be retained by the sealing mixture subsequent to the sealing mixture being released.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A balun circuit includes a first transformer comprising a first inductor and a second inductor, the first inductor having an electrical value different than the second inductor, a second transformer comprising a third inductor and a fourth inductor, the third inductor having an electrical value different than the fourth inductor, the first inductor connected to a positive terminal of a balanced port, the third inductor connected to a negative terminal of the balanced port, the second inductor connected to an unbalanced port and the fourth inductor connected to a node.

Abstract: A method of improving joint health in a subject in need thereof comprises administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the subject in need thereof.

Abstract: The present invention relates to compounds of formula I: in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A method of increasing height in a pediatric subject comprises enterally administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the pediatric subject in need thereof. A method of promoting linear bone growth in a pediatric subject comprises enterally administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the pediatric subject in need thereof. A method of obtaining an exosome-enriched product from cheese whey comprises subjecting the cheese whey to microfiltration (MF), ultrafiltration (UF), and diafiltration (DF) steps, wherein the MF, UF, and DF steps employ, successively, membranes with cut off values which gradually decrease in size with each filtration step, wherein the cheese whey is sweet cheese whey and has a pH from about 6.0 to about 6.5.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: A system includes an optical fiber assembly, a receiver and a telescope, the receiver being positioned at a receiving end of the optical fiber assembly, the telescope being positioned at a collecting end, the receiver being arranged to receive uplink modulated light signals collected by the telescope and travelling through the optical fiber assembly, the telescope comprising an optical concentrator having an inlet face and an outlet face with a surface area smaller than that of the inlet face, the telescope further including a gradient-index lens dispose d coaxially with respect to the optical concentrator so that an inlet face of the gradient-index lens extends opposite the outlet face of the optical concentrator, the collecting end of the optical fiber assembly opening out opposite an outlet face of the gradient-index lens.

Abstract: The present disclosure relates to a wound treatment dressing in which an absorbent layer comprises an odour-inhibiting mixture; wherein the odour-inhibiting mixture comprises coffee grounds. More particularly, a wound treatment dressing is provided for the absorption of odours in wounds, including pressure ulcers, leg ulcers, cancerous wounds, diabetic foot ulcers, burns, traumatic or surgical wounds, which comprises an odour-inhibiting mixture with coffee grounds.

Abstract: A method of preventing, reducing, or delaying the onset of fatty liver disease in a subject comprises enterally administering intact bovine milk-derived exosomes consisting of endogenous cargo to a subject in need thereof in an amount effective to reduce hepatic lipid accumulation. In a specific embodiment, the intact bovine milk-derived exosomes consisting of endogenous cargo can be administered in an amount effective to reduce de novo lipogenesis in the subject. The intact bovine milk-derived exosomes consisting of endogenous cargo can be administered to the subject directly or in a nutritional composition.

Abstract: A method of obtaining an exosome-enriched product comprises providing a whey-containing bovine milk fraction, conducting a first centrifugation of the whey-containing bovine milk fraction to obtain a whey middle fraction, conducting a second centrifugation of the whey middle fraction at an increased speed to obtain a concentrated whey fraction, filtering the concentrated whey fraction to obtain a filtered whey fraction, and conducting a third centrifugation of the filtered whey fraction at a further increased speed to obtain an exosome-enriched product. The exosome-enriched product comprises intact exosomes and less than 5 wt % casein based on the total weight of protein in the exosome-enriched product. Nutritional compositions comprise protein, carbohydrate, and/or fat, and exosomes provided by addition of the exosome-enriched product. A method of improving insulin sensitivity in a subject comprises administering a nutritional composition comprising the exosome-enriched product.

Abstract: In certain aspects, a method is provided for measuring power using a resistive element coupled between a power amplifier and an antenna. The method includes squaring a voltage from a first terminal of the resistive element to obtain a first signal, squaring a voltage from a second terminal of the resistive element to obtain a second signal, and generating a measurement signal based on a difference between the first signal and the second signal. In some implementations, the resistive element is implemented with a power switch.

Abstract: Holster, support and anchorage quick release system for guns that comprises left and right assembly parts configured to guide the gun when holstered, a trigger guard ratchet, a release button and a locking mechanism, wherein the left and right assembly parts configure a holster that is laterally opened where, once the gun is holstered, the muzzle and the full length of the barrel remain leaning outwards, the holstering of the gun activates the ratchet when yielding under the insertion of the trigger guard, locking the gun in the holster and the release of the gun is produced by the actuation on the locking mechanism and the release button, so that the drawing of the gun is performed perpendicularly to the barrel, allowing to aim from the very first instant of the release of the gun, avoiding unneeded movements and providing a shooter with more time.

Abstract: Methods of decreasing muscle atrophy and/or promoting muscle regeneration in a subject at risk of muscle atrophy comprise orally administering a nutritional composition comprising at least one of protein, fat and carbohydrate, and bovine milk-isolated exosomes comprising intact exosomes. In specific embodiments, the subject suffers from malnutrition, acquired immune deficiency syndrome (AIDS), cancer, diabetes, chronic obstructive pulmonary disease (COPD), amyotrophic lateral sclerosis (ALS), non-alcoholic fatty liver disease (NAFLD), or a burn injury, or has undergone clinical corticosteroid treatment.

Abstract: In certain aspects, a method is provided for measuring power using a resistive element coupled between a power amplifier and an antenna. The method includes squaring a voltage from a first terminal of the resistive element to obtain a first signal, squaring a voltage from a second terminal of the resistive element to obtain a second signal, and generating a measurement signal based on a difference between the first signal and the second signal. In some implementations, the resistive element is implemented with a power switch.

Abstract: Methods, systems and apparatuses may provide for technology that determines the size of a graphics primitive, renders pixels associated with the graphics primitive on a per tile basis if the size exceeds a threshold, and renders the pixels associated with the graphics primitive in a mesh order if the size does not exceed the threshold. In one example, the technology discards state data associated with the graphics primitive in response to a completion of rendering the pixels associated with the graphics primitive in the mesh order.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: The invention relates to a plenoptic ocular device intended to be coupled in an ocular port of an optical instrument configured to generate a real image of a sample on a focal plane situated in a region close to said ocular port, said plenoptic ocular device being configured to capture said real image, generate a set of elemental images and send them to recording means with spatial discretisation which in turn comprises communication means configured to transmit the set of elemental images to external image processing means.

Abstract: Methods, systems and apparatuses may provide for technology that determines that a state of a plurality of primitives is associated with out-of-order execution. The plurality of primitives is associated with a raster order. The technology reorders the plurality of primitives from a raster order, and distributes one or more of pixel processing operations or rasterization operations associated with the plurality of primitives to load balance across one or more of a plurality of execution units of a graphics processor or a graphics pipeline of the graphics processor.