Patents by Inventor Jorge A. Leon

Jorge A. Leon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein kinase C activators and their use in decreasing expression of cell antigens
    Publication number: 20020040062
    Abstract: A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided for this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.
    Type: Application
    Filed: February 13, 2001
    Publication date: April 4, 2002
    Applicant: The Trustees of Columbia University
    Inventors: Paul B. Fisher, Jorge A. Leon
  • Protein kinase C activators and their use in decreasing expression of cell antigens
    Patent number: 6187819
    Abstract: A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: February 13, 2001
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul B. Fisher, Jorge A. Leon
  • Protein kinase C activators and their use in increasing expression of cell antigens
    Patent number: 6069174
    Abstract: A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: May 30, 2000
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul B. Fisher, Jorge A. Leon
  • Fire selector system for selecting between automatic and semi-automatic operation of a gun
    Patent number: 5705763
    Abstract: A fire selector system for selecting between automatic and semi-automatic operation of a gun is provided. The system is mountable on a reciprocating slide of the gun and into operative relationship with the trigger bar of the gun. A member of the selector system is movable between forward and rearward longitudinal positions. The forward longitudinal position allows the member to assume an activating longitudinal position for automatic operation of the gun. The rearward longitudinal position prevents the member from assuming its activating longitudinal position, thereby effecting semi-automatic operation of the gun. The member repetitively contacts a contact area of the trigger bar as it reciprocates with a reciprocating slide of the gun during automatic operation. Further, the device is easily installed and removed from the reciprocating slide depending on user requirements.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: January 6, 1998
    Inventor: Jorge A. Leon
  • Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol
    Patent number: 5681860
    Abstract: A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.
    Type: Grant
    Filed: September 21, 1993
    Date of Patent: October 28, 1997
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul B. Fisher, Jorge A. Leon