Patents by Inventor Jorge Amador Berlanga Acosta

Jorge Amador Berlanga Acosta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210252109
    Abstract: The present invention is related to the use of the growth hormone releasing peptide-6 (GHRP-6) for the manufacture of a late cardioprotective and cardiac restoration medicament. Said late cardioprotective and cardiac restoration medicament comprises GHRP-6 and a pharmaceutically acceptable excipient or vehicle. It also provides a method for the treatment of a disease that involves a low cardiac output, wherein a therapeutically effective amount of a late cardioprotective and cardiac restoration medicament comprising GHRP-6 is administered to a subject in need. Said medicament allows treating in a late manner, even days later, the myocardium that suffered episodes of stunning, hibernation, ischemia and its consequences thereof.
    Type: Application
    Filed: August 19, 2019
    Publication date: August 19, 2021
    Inventors: Jorge Amador BERLANGA ACOSTA, Gerardo Enrique GUILLÉN NIETO, Diana GARCIA DEL BARCO HERRERA, Francisco HERNÁNDEZ BERNAL, Sonia GONZALEZ BLANCO, Raimundo UBIETA GÓMEZ
  • Publication number: 20210196793
    Abstract: The invention discloses a pharmaceutical combination comprising epidermal growth factor (EGF) and the hexapeptide secretagogue GHRP6, useful for the restoration of brain damage, by stimulating mechanisms of differentiation and neuronal specialization in undifferentiated cells residing in the central nervous system or in neuronal cells. The invention also encompasses the use of the above mentioned biomolecules in the manufacture of a pharmaceutical combination for the restoration of brain damage. In addition, the invention provides a method of restoring brain damage in which a therapeutically effective amount of a pharmaceutical combination comprising EGF and GHRP6 is administered to a patient in need thereof. The efficacy of the pharmaceutical combination has a broad therapeutic window: it is independent of whether the pharmacological intervention occurs in the first or further hours after the brain damage, which broadens the therapeutic window.
    Type: Application
    Filed: August 16, 2019
    Publication date: July 1, 2021
    Inventors: Diana GARCIA DEL BARCO HERRERA, Gerardo Enrique GUILLÉN NIETO, Mariela VAZQUEZ CASTILLO, Francisco HERNÁNDEZ BERNAL, Tatiana ZALDIVAR VAILLANT, Pablo Arsenio DIAZ REYES, ldania Caridad BALADRON CASTRILLO, Vladimir Armando BESADA PÉREZ, Sonia GONZALEZ BLANCO, Jorge Amador BERLANGA ACOSTA, Héctor Manuel PÉREZ SAAD
  • Patent number: 10765341
    Abstract: The present invention is related to a system and method to ensure the reproducibility of the position of the feet and lower parts of the legs during Magnetic Resonance Imaging (MRI) studies, and to obtain robust quantitative information through the time. The system includes a device that is inserted into the radiofrequency coils of any MRI equipment. The device includes a foot support section, a leg support section and a base adapted to allow that the abovementioned sections be fixed in it. With this device and method, and through external and internal markers, quantitative studies of the evolution of pathophysiological phenomena that affect the anatomy and physiology of the feet and lower parts of the legs are performed.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: September 8, 2020
    Assignee: CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA
    Inventors: Carlos Alberto Cabal Mirabal, Evelio Rafael González Dalmau, Luis Manuel Flores Díaz, Jorge Amador Berlanga Acosta, Luis Saturnino Herrera Martinez
  • Publication number: 20180256112
    Abstract: The present invention is related to a stereotaxic frame for extremities that ensures that the extremity position is fixed and reproducible; keeping the same geometric conditions of the measurement or treatment devices regards the extremity, or part thereof, during the study or therapy. The frame comprises a positioning and fixing holder for the extremity and a measuring or treatment system, that includes a geometric locus where the measurement or treatment device is allocated, ensuring that the relative position of said device regards the region of the extremity under examination or treatment is reproducible.
    Type: Application
    Filed: September 22, 2016
    Publication date: September 13, 2018
    Inventors: Carlos Alberto CABAL MIRABAL, Evelio Rafael GONZÁLEZ DALMAU, Leonardo ORAMAS DIAZ, Luis Saturnino HERRERA MARTINEZ, Jorge Amador BERLANGA ACOSTA, José Ignacio FERNÁNDEZ MONTEQUÍN, Gerardo Enrique GUILLÉN NIETO, Luis Manuel FLORES DÍAZ, Orestes Lucio CABAÑAS RODRÍGUEZ, Sonia GONZALEZ BLANCO, Raimundo UBIETA GÓMEZ
  • Publication number: 20180015145
    Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
    Type: Application
    Filed: July 31, 2017
    Publication date: January 18, 2018
    Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
  • Patent number: 9717776
    Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: August 1, 2017
    Assignees: CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA, CONSEJO SUPERIOR DE INVESTIGACIONES CENTÍFICAS
    Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
  • Publication number: 20160157750
    Abstract: The present invention is related to a system and method to ensure the reproducibility of the position of the feet and lower parts of the legs, during the Magnetic Resonance Imaging (MRI) studies, to obtain robust quantitative information through the time. The system comprises a device that is inserted into the radiofrequency coils of any MRI equipment. Said device comprises a foot support section, a leg support section and a base adapted to allow that the abovementioned sections be fixed in it. With this device and method, through external and internal markers, quantitative studies of the evolution of pathophysiological phenomena that affect the anatomy and physiology of the feet and lower parts of the legs are performed.
    Type: Application
    Filed: June 23, 2014
    Publication date: June 9, 2016
    Inventors: Carlos Alberto Cabal Mirabal, Evelio Rafael González Dalmau, Luis Manuel Flores Díaz, Jorge Amador Berlanga Acosta, Luis Saturnino Herrera Martinez
  • Publication number: 20150182590
    Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 2, 2015
    Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
  • Patent number: 9034826
    Abstract: The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: May 19, 2015
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Patent number: 8741848
    Abstract: The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: June 3, 2014
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Vivian Maria Sáez Martinez, Rolando Páez Meireles, Jorge Amador Berlanga Acosta, Blas Yamir Betancourt Rodriguez, José Ángel Ramón Hernández
  • Publication number: 20140105990
    Abstract: The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensitive-motor neuropathy, as well as in ischemic neuritis.
    Type: Application
    Filed: December 26, 2013
    Publication date: April 17, 2014
    Applicant: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Patent number: 8642552
    Abstract: The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: February 4, 2014
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Patent number: 8367620
    Abstract: Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: February 5, 2013
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Rolando Eduardo Rodriguez Fernandez, Ania De La Nuez Veulens, Mario Pablo Estrada Garcia, Rebeca Martinez Rodriguez, Glay Chinea Santiago, Osvaldo Reyes Acosta, Julio Raul Fernandez Masso, Diana Garcia del Barco Herrera, Jorge Amador Berlanga Acosta, Alexis Musacchio Lasa
  • Publication number: 20100136062
    Abstract: The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anaesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.
    Type: Application
    Filed: October 1, 2007
    Publication date: June 3, 2010
    Inventors: Jose Ignacio Fernandez Montequin, Luis Saturnino Herrera Martinez, Jorge Amador Berlanga Acosta, Diana Garcia Del Barco Herrera, Danay Cibrian Vera, Gerardo Enrique Guillen Nieto, Raimundo Ubieta Gomez, Sonia Gonzalez Blanco, Vivian Maria Saez Martinez
  • Publication number: 20100093616
    Abstract: The present invention is directed to stimulate the neuroregeneration of the central nervous system due to autoimmune damage. In particular the pharmaceutical combination that comprise therapeutically effective concentrations of the Epidermal Growth Factor and the Growth Hormone Releasing Peptide-6, is administrated to a subject that suffers from symptoms of Multiple Sclerosis and Optic Neuromyelitis and corrects the demyelination caused by autoreactive cells in central nervous system.
    Type: Application
    Filed: February 24, 2006
    Publication date: April 15, 2010
    Inventors: Diana Garcia Del Barco Herrera, Gerardo Enrique Guillén Nieto, Jorge Amador Berlanga Acosta, Freya de los Milagros Freyre Almeida, Danay Cibrian Vera, Eduardo Pentón Arias
  • Publication number: 20100055118
    Abstract: Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
    Type: Application
    Filed: February 28, 2007
    Publication date: March 4, 2010
    Applicant: CENTRO DE INGENÍERA GENÉTICA Y BIOTECNOLOGÍA
    Inventors: Rolando Eduardo Rodriguez Fernandez, Ania De La Nuez Veulens, Mario Pablo Estrada Garcia, Rebeca Martinez Rodriguez, Glay Chinea Santiago, Osvaldo Reyes Acosta, Julio Raul Fernandez Masso, Diana Garcia Del Barco Herrera, Jorge Amador Berlanga Acosta, Alexis Musacchio Lasa
  • Publication number: 20090220608
    Abstract: The present invention relates to a pharmaceutical composition that comprises polymeric microspheres containing epidermal growth factor (EGF) for the application, by the parenteral route, into the lower limbs of diabetic patients with cutaneous chronic ischemic ulcerative wounds. The pharmaceutical composition described herein, in contrast with the state of the art, is useful because reduce the administration frequency during the treatment and allows for the healing of the ulcerative wounds in a shorter time interval with respect to the injection of equivalent quantities of non-encapsulated EGF.
    Type: Application
    Filed: January 29, 2007
    Publication date: September 3, 2009
    Inventors: Vivian Maria Sáez Martinez, Rolando Páez Meireles, Jorge Amador Berlanga Acosta, Blas Yamir Betancourt Rodriguez, José Ángel Ramón Hernández
  • Publication number: 20090074850
    Abstract: The present invention is related to the use of topical formulations that contain epidermal growth factor encapsulated in or associated to deformable or conventional liposomes to be applied on the surface of and around chronic ischemic skin lesions. The formulations of the present invention, in contrast with the previous art, are useful because they provide a high bioavailability of EGF in the tissue deep below the lesions and for preventing diabetic foot amputation.
    Type: Application
    Filed: December 28, 2006
    Publication date: March 19, 2009
    Inventors: Elder Pupo Escalona, Rolando Paez Meireles, Jorge Amador Berlanga Acosta, Blas Yamir Betancourt Rodriquez