Abstract: A method and system for the localization and characterization of the generators of human brain electromagnetic physiological activity includes a set of bioelectromagnetic amplifiers, sensorial stimulators, and a computer based system for signal analog to digital conversion and recording. Sufficient statistics, including higher order statistical moments, for event related components are computed from the recorded signals, either in the time, frequency, or time-frequency domain, retaining stationary, non-stationary, linear, and non-linear information. The localizations, orientations, activities, and connectivities of the generators are obtained by solving the inverse problem using sufficient statistics under anatomical and functional constraints. Realistic head geometry and conductivity profiles are used to transform the measurements into infinite homogeneous medium measurements, through use of ananatomical deconvolution operator, thus simplifying optimally inverse solution computations.

Abstract: A method and system for the evaluation and visual display of abnormal electromagnetic physiological activity of the brain and the heart utilizes a set of bioelectric amplifiers and a computer based system for the recording and analog to digital conversion of human electrophysiological signals. The signals collected are expanded in selected spatio-temporal functional bases, and parametric models are used for summarizing the statistical properties of the coefficients. Multivariate topographic maps and curves are computed based on the comparison of the estimated parameters for a patient and the regression equations for the parameters calculated from a normative database. The multivariate maps and curves are visually displayed in a diagnostically useful color-coded probability scale.