Abstract: A system for managing wheel kinematics during a small overlap collision event includes a deflector apparatus. The deflector is configured to direct a wheel away from an occupant compartment of a vehicle. The deflector includes a first section arranged at an inside wall of a wheel well facing a wheel, near the base of a hinge-pillar. The first section includes a hollow structure configured to absorb energy from the collision event by plastically deforming. The deflector also includes a second section arranged at an angle to the wheel and configured to deflect the wheel laterally outwards from the vehicle away from an occupant compartment during the small overlap collision event. The deflector may be formed of extruded aluminum. The system may include an absorber arranged behind the first section and configured to further absorb energy from the collision event by plastically deforming.

Abstract: A system for managing wheel kinematics during a small overlap collision event includes a deflector apparatus. The deflector is configured to direct a wheel away from an occupant compartment of a vehicle. The deflector includes a first section arranged at an inside wall of a wheel well facing a wheel, near the base of a hinge-pillar. The first section includes a hollow structure configured to absorb energy from the collision event by plastically deforming. The deflector also includes a second section arranged at an angle to the wheel and configured to deflect the wheel laterally outwards from the vehicle away from an occupant compartment during the small overlap collision event. The deflector may be formed of extruded aluminum. The system may include an absorber arranged behind the first section and configured to further absorb energy from the collision event by plastically deforming.

Abstract: This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

Abstract: The invention provides a method for detecting or monitoring Alzheimer's disease and other forms of dementia using positron emission tomography (PET) or single-photon emission computed tomagraphy (SPECT) and radiolabeled, serotonin 5-HT1A receptor-specific tracers (such as [F-18]MPPF, [F-18]FCWAY, [C-11]WAY-100635, and other radiolabeled compounds having agonistic or antagonistic effect on serotonin receptors), for detection or monitoring of pathological changes (i.e., neuronal cell loss) associated with dementia.

Abstract: A method for labeling structures, such as ?-amyloid plaques and neurofibrillary tangles, in vivo or in vitro, is provided and comprises contacting brain tissue with one or more compounds, preferably radiolabeled for detection by positron emission tomography (PET).