Patents by Inventor Jorge Bezerra

Jorge Bezerra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIVER SUPPORT SYSTEM COMPRISING LIVER ORGANOIDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20210292714
    Abstract: Disclosed herein are bioartificial liver systems (“BAL” or “liver assist device”) that employ liver organoids. The disclosed systems may be used to provide a therapeutic benefit to an individual in need thereof, particularly an individual having compromised liver function. The systems may include an in vivo or ex vivo component, wherein a liver function is provided to the individual using the disclosed systems.
    Type: Application
    Filed: September 27, 2019
    Publication date: September 23, 2021
    Inventors: Takanori Takebe, Jorge A. Bezerra
  • CLASSIFICATION AND DIAGNOSIS OF THE MOLECULAR BASIS OF CHOLESTASIS
    Publication number: 20110071034
    Abstract: The methods and compositions of the invention find use in the clinical diagnosis of cholestasis related syndromes, particularly PFIC types 1, 2, and 3; BRIC types 1 and 2; Alagille syndrome, and alpha 1-antitrypsin deficiency. The compositions of the invention include isolated nucleic acid molecules and oligonucleotide pairs suitable for use in amplifying regions of cholestasis related genes. Compositions of the invention include a cholestasis related gene resequencing microarray suitable for determining the nucleotide sequence of a region of a cholestasis related gene. Knowledge of the nucleotide sequence of one or more regions of a patient's cholestasis related gene allows diagnosis of the patient's syndrome.
    Type: Application
    Filed: October 14, 2010
    Publication date: March 24, 2011
    Inventor: JORGE BEZERRA
  • Classification and diagnosis of the molecular basis of cholestasis
    Patent number: 7847088
    Abstract: The methods and compositions of the invention find use in the clinical diagnosis of cholestasis related syndromes, particularly PFIC types 1, 2, and 3; BRIC types 1 and 2; Alagille syndrome, and alpha1-antitrypsin deficiency. The compositions of the invention include isolated nucleic acid molecules and oligonucleotide pairs suitable for use in amplifying regions of cholestasis related genes. Compositions of the invention include a cholestasis related gene resequencing microarray suitable for determining the nucleotide sequence of a region of a cholestasis related gene. Knowledge of the nucleotide sequence of one or more regions of a patient's cholestasis related gene allows diagnosis of the patient's syndrome.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: December 7, 2010
    Assignee: Children's Hospital Medical Center
    Inventor: Jorge Bezerra
  • Classification and diagnosis of the molecular basis of cholestasis
    Publication number: 20080254994
    Abstract: The methods and compositions of the invention find use in the clinical diagnosis of cholestasis related syndromes, particularly PFIC types 1, 2, and 3; BRIC types 1 and 2; Alagille syndrome, and alpha 1-antitrypsin deficiency. The compositions of the invention include isolated nucleic acid molecules and oligonucleotide pairs suitable for use in amplifying regions of cholestasis related genes. Compositions of the invention include a cholestasis related gene resequencing microarray suitable for determining the nucleotide sequence of a region of a cholestasis related gene. Knowledge of the nucleotide sequence of one or more regions of a patient's cholestasis related gene allows diagnosis of the patient's syndrome.
    Type: Application
    Filed: January 28, 2008
    Publication date: October 16, 2008
    Inventor: Jorge Bezerra