Patents by Inventor Jorge Casals-Stenzel

Jorge Casals-Stenzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-Cyano-prostacyclin derivatives and use as medicines
    Patent number: 4364950
    Abstract: 5-cyano-prostacyclins of the formula ##STR1## wherein R.sub.1 is OR.sub.2 or NHR.sub.3 ; R.sub.2 and R.sub.3 each independently is (a) H, (b) C.sub.1-10 -alkyl, (c) C.sub.1-10 -alkyl substituted by halo, C.sub.1-4 -alkoxy or phenyl, 1-naphthyl or 2-naphthyl, each optionally substituted as defined below, (d) C.sub.4-10 -cycloalkyl, (e) C.sub.4-10 -cycloalkyl substituted by C.sub.1-4 -alkyl, (f) phenyl, 1-naphthyl or 2-naphthyl, (g) phenyl, 1-naphthyl or 2-naphthyl substituted by 1-3 halogen atoms, phenyl, 1-3 alkyl groups of 1-4 C atoms each, or a chloromethyl-, fluoromethyl-, trifluoromethyl-, carboxyl-, hydroxy- or alkoxy-group of 1-4 C atoms, or (h) an aromatic, 5- or 6-membered heterocyclic ring containing one hetero atom which is O, N or S, the remaining atoms being carbon; R.sub.3 also possibly being an acyl group of a C.sub.
    Type: Grant
    Filed: November 2, 1981
    Date of Patent: December 21, 1982
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Helmut Vorbruggen, Bernd Raduchel, Jorge Casals-Stenzel, Ekkehard Schillinger, Michael H. Town
  • 6.beta.,7.beta.;15,16-Dimethylene-1,4-androstadien-3-ones, their preparation and use as medicinal agents
    Patent number: 4291029
    Abstract: Compounds of the formula ##STR1## wherein the 15,16-methylene group is in the .alpha.- or .beta.-position, andE is ##STR2## are useful as diuretics.
    Type: Grant
    Filed: May 29, 1980
    Date of Patent: September 22, 1981
    Assignee: Schering, Aktiengesellschaft
    Inventors: Rudolf Wiechert, Dieter Bittler, Ulrich Kerb, Klaus Prezewowsky, Jorge Casals-Stenzel, Wolfgang Losert
  • Prostaglandin-I.sub.2 derivatives
    Patent number: 4191694
    Abstract: Prostane derivatives of the formula ##STR1## wherein R.sub.1 is OR.sub.2 or NHR.sub.3 ;R.sub.2 is hydrogen, C.sub.1-10 alkyl, C.sub.4-10 cycloalkyl, C.sub.6-10 aryl, or a 5 or 6 membered heterocyclic ring having 1-3 hetero atoms selected from O, N and S;R.sub.3 is the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms;W is (a) an OH-substituted methylene group, (b) a ##STR2## wherein the OH-groups in (a) or (b) can be in the .alpha.- or .beta.-position, or (c) such a group wherein the H atom of the OH group is replaced by the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms or by a conventional etherifying OH-blocking group;R.sub.4 is OH or hydroxy whose H atom is replaced as defined for W; andR.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 each independently is hydrogen or alkyl of 1-5 carbon atoms; or R.sub.9 and R.sub.10 together represent a direct bond; and, when R.sub.11 is alkyl, R.sub.
    Type: Grant
    Filed: July 26, 1978
    Date of Patent: March 4, 1980
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Bernd Raduchel, Norbert Schwarz, Helmut Vorbruggen, Bernd Muller, Gerda Mannesmann, Olaf Loge, Ekkehardt Schillinger, Jorge Casals-Stenzel
  • 17.beta.-Hydroxy-4-androsten-3-ones and process for the preparation thereof
    Patent number: 4180570
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.2 is hydrogen or an organic acid residue;R.sub.3 is methyl or ethyl;R.sub.4 is hydrogen or methyl; ##STR2## wherein R.sub.1 is lower alkyl; and ##STR3## and when R.sub.2 is a dibasic acid residue, the physiologically acceptable salts thereof with the free acid moiety of the R.sub.2 group, are physiologically active, e.g., are diuretics having aldosterone antagonist effects.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: December 25, 1979
    Assignee: Schering Aktiengesellschaft
    Inventors: Rudolf Wiechert, Dieter Bittler, Ulrich Kerb, Jorge Casals-Stenzel, Wolfgang Losert
  • Spirolactones
    Patent number: 4129564
    Abstract: New spirolactones of the formula ##STR1## R is a lower alkyl of up to 5 carbon atoms, and ##STR2##
    Type: Grant
    Filed: November 11, 1977
    Date of Patent: December 12, 1978
    Assignee: Schering, A.G. Patentabteilung
    Inventors: Rudolf Wiechert, Dieter Bittler, Ulrich Kerb, Jorge Casals-Stenzel, Wolfgang Losert
  • 4-Androsten-3-ones and process for the preparation thereof
    Patent number: 4118488
    Abstract: 4-Androsten-3-ones of the formula ##STR1## wherein R.sub.1 is hydrogen or the acyl radical of an organic or inorganic acid, R.sub.2 is hydrogen, alkyl, or the acyl radical of an organic or inorganic acid, R.sub.3 is methyl or ethyl, R.sub.4 is hydrogen or methyl, ##STR2## and R.sub.5 is lower alkyl, have diuretic activity.
    Type: Grant
    Filed: March 3, 1977
    Date of Patent: October 3, 1978
    Assignee: Schering Aktiengesellschaft
    Inventors: Rainer Philippson, Bernhard Krieger, Jorge Casals-Stenzel, Ulrich Kerb, Wolfgang Losert, Klaus Prezewowsky, Rudolf Wiechert, Dieter Bittler