Patents by Inventor Jorge D. Brioni

Jorge D. Brioni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF OSTEOARTHRITIS PAIN
    Publication number: 20160089378
    Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
    Type: Application
    Filed: October 12, 2015
    Publication date: March 31, 2016
    Inventors: Marlon D. Cowart, Gin C. Hsieh, Jorge D. Brioni, James P. Sullivan
  • Treatment of osteoarthritis pain
    Patent number: 9186353
    Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: November 17, 2015
    Assignee: AbbVie Inc.
    Inventors: Marlon D. Cowart, Gin C. Hsieh, Jorge D. Brioni, James P. Sullivan
  • USE OF SELECTIVE DOPAMINE D4 RECEPTOR AGONISTS FOR TREATING SEXUAL DYSFUNCTION
    Publication number: 20140256738
    Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.
    Type: Application
    Filed: November 11, 2013
    Publication date: September 11, 2014
    Inventors: Jorge D. Brioni, Teodozyj Kolasa, Gin C. Hsieh, Diana L. Donnelly-Roberts
  • Macrocyclic benzofused pyrimidine derivatives
    Patent number: 8735411
    Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: May 27, 2014
    Assignee: AbbVie Inc.
    Inventors: Robert J. Altenbach, Huaqing Liu, Irene Drizin, Marlon D. Cowart, Neil Wishart, David J. Babinski, Robert J. Gregg, Timothy A. Esbenshade, Gin C. Hsieh, Jorge D. Brioni, Marie P. Honore, Lawrence A. Black, Chen Zhao, Brian D. Wakefield, Kathryn J. Hancock
  • Treatment of schizophrenia and related disorders
    Patent number: 8252801
    Abstract: The invention relates to a method of administering histamine H3 antagonist and an antipsychotic therapeutic agent, compositions comprising a histamine H3 antagonist and an antipsychotic therapeutic agent, and a related article of manufacture.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: August 28, 2012
    Assignee: Abbott Laboratories
    Inventors: Lynne E. Rueter, Kaitlin E. Browman, Jorge D. Brioni, Marlon D. Cowart, Timothy A. Esbenshade, Gerard B. Fox
  • Method for pain treatment
    Patent number: 7985745
    Abstract: This invention discloses a method of treating pain by administering histamine H4 receptor ligands and compositions comprising the same.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: July 26, 2011
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Robert J. Altenbach, Huaqing Liu, Irene Drizin, Neil Wishart, David J. Babinski, Robert J. Gregg, Arthur A. Hancock, Kathryn J. Hancock, legal representative, Timothy A. Esbenshade, Gin C. Hsieh, Jorge D. Brioni, Marie P. Honore, Lawrence A. Black, Chen Zhao, Brian D. Wakefield
  • TREATMENT OF OSTEOARTHRITIS PAIN
    Publication number: 20100273778
    Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
    Type: Application
    Filed: April 26, 2010
    Publication date: October 28, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Marlon D. Cowart, Gin C. Hsieh, Jorge D. Brioni, James P. Sullivan
  • COMPOSITIONS FOR TREATMENT OF COGNITIVE DISORDERS
    Publication number: 20090221648
    Abstract: The present invention relates to compositions for treatment of cognitive deficits. Such compositions can have a nicotinic acetylcholine receptor ligand, of either ?4?2 subtype or ?7 nicotinic acetylcholine subtype, and a histamine-3 receptor ligand, a method of using the same, and a related article of manufacture. Combinations of such active agents with psychostimulants or monoamine reuptake inhibitors also is contemplated.
    Type: Application
    Filed: December 18, 2008
    Publication date: September 3, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Lynne E. Rueter, Gerald B. Fox, Kaitlin E. Browman, James P. Sullivan, Jorge D. Brioni, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Kathleen H. Mortell, Murali Gopalakrishnan
  • Method for Pain Treatment
    Publication number: 20080194538
    Abstract: This invention discloses a method of treating pain by administering histamine H4 receptor ligands and compositions comprising the same.
    Type: Application
    Filed: September 28, 2007
    Publication date: August 14, 2008
    Inventors: Marlon D. Cowart, Robert J. Altenbach, Huaqing Liu, Irene Drizin, Neil Wishart, David J. Babinski, Robert J. Gregg, Arthur A. Hancock, Timothy A. Esbenshade, Gin C. Hsieh, Jorge D. Brioni, Marie P. Honore, Lawrence A. Black, Chen Zhao, Brian D. Wakefield, Kathryn J. Hancock
  • Macrocyclic Benzofused Pyrimidine Derivatives
    Publication number: 20080188452
    Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
    Type: Application
    Filed: September 28, 2007
    Publication date: August 7, 2008
    Inventors: Robert J. Altenbach, Huaqing Liu, Irene Drizin, Marlon D. Cowart, Neil Wishart, David J. Babinski, Robert J. Gregg, Arthur A. Hancock, Kathryn J. Hancock, Timothy A. Esbenshade, Gin C. Hsieh, Jorge D. Brioni, Marie P. Honore, Lawrence A. Black, Chen Zhao, Brian D. Wakefield
  • DETERMINATION OF HISTAMINE-3 BIOACTIVITY
    Publication number: 20080159958
    Abstract: The invention relates to an in vivo method for determining the bioactivity of chemical compounds as histamine-3 receptor (H3R) ligands, and provides animal models to determine such bioactivity. The invention further relates to methods for screening therapeutic compounds demonstrating a desired property, using such methods and models described.
    Type: Application
    Filed: December 5, 2007
    Publication date: July 3, 2008
    Applicant: Abbott Laboratories
    Inventors: Richard J. Radek, R. Scott Bitner, Marlon D. Cowart, Jorge D. Brioni, Timothy A. Esbenshade
  • Benzimidazoles that are useful in treating sexual dysfunction
    Patent number: 7351828
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: April 1, 2008
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde
  • Benzimidazoles that are useful in treating male sexual dysfunction
    Patent number: 7022728
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: April 4, 2006
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde
  • Benzimidazoles that are useful in treating sexual dysfunction
    Patent number: 6960589
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein L is C1-4 alkyl; RA, RB, RC, RD, and RE, are as described in the specification; Z is selected from the group consisting of N, C and CH; and A is aryl and heteroaryl as described in the specification.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: November 1, 2005
    Assignee: Abbott Laboratories
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde, Kenneth M. Engstrom
  • Benzimidazoles that are useful in treating sexual dysfunction
    Publication number: 20040127504
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: September 5, 2003
    Publication date: July 1, 2004
    Inventors: Marlon D. Cowart, Meena V. Patel, Teodozyi Kolasa, Jorge D. Brioni, Jeffrey J. Rohde, Kenneth M. Engstrom, Andrew O. Stewart, Jerome F. Daanen, Pramila A. Bhatia
  • Benzimidazoles that are useful in treating sexual dysfunction
    Publication number: 20040110766
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: October 31, 2003
    Publication date: June 10, 2004
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde
  • Indazole derivatives that are activators of soluble guanylate cyclase
    Publication number: 20040048866
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: February 26, 2003
    Publication date: March 11, 2004
    Inventors: Teodozyj Kolasa, Jorge D. Brioni, Vijaya Gracias, Masaki Nakane, Meena V. Patel, Jeffrey Rohde
  • Potassium channel openers
    Patent number: 6645968
    Abstract: Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: November 11, 2003
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Hao Bai, Jorge D. Brioni, William A. Carroll, Murali Gopalakrishnan, Robert J. Gregg, Mark W. Holladay, Peggy P. Huang, John F. Kincaid, Michael E. Kort, Philip R. Kym, John K. Lynch, Arturo Perez-Medrano, Henry Q. Zhang
  • Benzimidazoles that are useful in treating sexual dysfunction
    Publication number: 20030162790
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: September 6, 2002
    Publication date: August 28, 2003
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni, Jeffrey Rohde, Kenneth M. Engstrom
  • Benzimidazoles that are useful in treating sexual dysfunction
    Publication number: 20030008878
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: June 5, 2001
    Publication date: January 9, 2003
    Inventors: Marlon D. Cowart, Pramila A. Bhatia, Jerome F. Daanen, Andrew O. Stewart, Meena V. Patel, Teodozyj Kolasa, Jorge D. Brioni