Patents by Inventor Jorge Elias Kalil Filho

Jorge Elias Kalil Filho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic application of C-terminal peptide
    Patent number: 9289485
    Abstract: A method for treating rheumatic heart disease comprising administering an immunogenic composition against group A beta hemolytic streptococcus.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: March 22, 2016
    Inventors: Luiza Guilherme Guglielmi, Jorge Elias Kalil Filho
  • METHOD FOR PRODUCING AND OBTAINING VARIABLE DOMAINS OF ANTI-DIGOXIN MONOCLONAL ANTIBODY FAB FRAGMENT USING THE MOLECULAR BIOLOGY CLONING TECHNIQUE
    Publication number: 20150240230
    Abstract: Method for producing and obtaining variable domains of anti-digoxin monoclonal antibody Fab fragment using the molecular biology cloning technique, and more precisely the present patent of invention relates to a method for producing and obtaining clones of the anti-digoxin antibody Fab fragment using phage display technology and the characterization of the binding thereof to the antigen; the present innovation pertains to the development of the product for therapeutic use having specific potency and a more precise dose for detoxification of patients undergoing treatment with digoxin.
    Type: Application
    Filed: May 15, 2013
    Publication date: August 27, 2015
    Inventors: Jorge Elias Kalil Filho, Ana Maria Moro, Viviane Midori Murata, Lilian Rumi Tsurata, Mariana Costa Braga Schmidt
  • THERAPEUTIC APPLICATION OF S. PYOGENES C-TERMINAL PEPTIDE
    Publication number: 20140220065
    Abstract: A method for treating rheumatic heart disease comprising administering an immunogenic composition against group A beta hemolytic streptococcus
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Inventors: LUIZA GUILHERME GUGLIELMI, JORGE ELIAS KALIL FILHO
  • Vaccine against group A beta hemolytic streptococcus and respective process for obtaining thereof
    Patent number: 8642049
    Abstract: VACCIN AGAINST GROUP A BETA HEMOLYTIC STREPTOCOCCUS AND RESPECTIVE PROCESS FOR OBTAINING THEREOF, which predicts the production of recombinant protein cloned from the gene emm5, which contains a sequence of oligonucleotides corresponding to 52 and/or 87 amino acid residues capable of protection, isolated after the sequential molecular identification of the epitopes from the M protein carboxy-terminal region, differing in 01 amino acid residue, identified by antibodies and T lymphocytes of health human beings and of patients carriers of rheumatic fever, capable of generating a protective response by antibodies depending on the T lymphocytes; prevention of the development of the autoimmune disease by the selected epitope was evaluated in vitro with T lymphocytes from the cardiac tissue of patients with lesions arising out of rheumatic fever.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: February 4, 2014
    Inventors: Luiza Guilherme Guglielmi, Jorge Elias Kalil Filho
  • Anti-HIV immunogens and methods for inducing an immune response
    Patent number: 8338582
    Abstract: The present invention refers to new epitopes recognized by CD4+ T-lymphocytes. In addition, the present invention refers to the uses of such epitopes and their combinations, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to a composition comprising said epitopes and the uses of said composition, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to anti-HIV-1 prophylactic vaccines and therapeutic vaccines. Furthermore, the present invention refers to a method for the identification of epitopes and methods for treating or preventing an infection caused by the HIV-1 virus.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: December 25, 2012
    Assignees: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Fundacao Zerbini, Universidade de Sao Paulo-USP
    Inventors: Edecio Cunha Neto, Jorge Elias Kalil Filho, Simone Goncalves Da Fonseca
  • Vaccine Against Group A Beta Hemolytic Streptococcus And Respective Process For Obtaining Thereof
    Publication number: 20100183518
    Abstract: VACCIN AGAINST GROUP A BETA HEMOLYTIC STREPTOCOCCUS AND RESPECTIVE PROCESS FOR OBTAINING THEREOF, which predicts the production of recombinant protein cloned from the gene emm5, which contains a sequence of oligonucleotides corresponding to 52 and/or 87 amino acid residues capable of protection, isolated after the sequential molecular identification of the epitopes from the M protein carboxy-terminal region, differing in 01 amino acid residue, identified by antibodies and T lymphocytes of health human beings and of patients carriers of rheumatic fever, capable of generating a protective response by antibodies depending on the T lymphocytes; prevention of the development of the autoimmune disease by the selected epitope was evaluated in vitro with T lymphocytes from the cardiac tissue of patients with lesions arising out of rheumatic fever.
    Type: Application
    Filed: July 19, 2007
    Publication date: July 22, 2010
    Applicant: Fundacao Zerbini
    Inventors: Luiza Guilherme Guglielmi, Jorge Elias Kalil Filho
  • Epitopes, combined epitopes, use of epitopes or their combination, composition, uses of the composition, anti-HIV-1 prophylactic vaccines, therapeutic vaccines, method for the identification of epitopes and methods for treatment and prevention
    Publication number: 20080260766
    Abstract: The present invention refers to new epitopes recognized by CD4+ T-lymphocytes. In addition, the present invention refers to the uses of such epitopes and their combinations, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to a composition comprising said epitopes and the uses of said composition, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to anti-HIV-1 prophylactic vaccines and therapeutic vaccines. Furthermore, the present invention refers to a method for the identification of epitopes and methods for treating or preventing an infection caused by the HIV-1 virus.
    Type: Application
    Filed: March 5, 2008
    Publication date: October 23, 2008
    Applicants: FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO, FUNDACAO ZERBINI, UNIVERSIDADE DE SAO PAULO - USP
    Inventors: Edecio Cunha Neto, Jorge Elias Kalil Filho, Simone Goncalves Da Fonseca