Patents by Inventor Jorge Filmus

Jorge Filmus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of hepatocellular carcinoma
    Patent number: 7883853
    Abstract: A method is provided for screening a subject for hepatocellular carcinoma by determining the level of glypican-3 (GPC3) in a body fluid sample from the subject. A further method is provided for diagnosing hepatocellular carcinoma by detecting GPC3 in a liver tissue sample. Also provided are antibodies which bind specifically to GPC3.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: February 8, 2011
    Assignee: Sunnybrook Health Sciences Centre
    Inventors: Jorge Filmus, Mariana Capurro
  • Diagnosis of hepatocellular carcinoma
    Publication number: 20050233392
    Abstract: A method is provided for screening a subject for hepatocellular carcinoma by determining the level of glypican-3 (GPC3) in a body fluid sample from the subject. A further method is provided for diagnosing hepatocellular carcinoma by detecting GPC3 in a liver tissue sample. Also provided are antibodies which bind specifically to GPC3.
    Type: Application
    Filed: May 22, 2003
    Publication date: October 20, 2005
    Inventors: Jorge Filmus, Mariana Capurro
  • Synthetic eukaryotic promoters containing two inducible elements
    Patent number: 5877018
    Abstract: Synthetic inducible eukaryotic promoters for the regulation of transcription of a gene achieve improved levels of protein expression and lower basal levels of gene expression. Such promoters contain at least two different classes of inducible elements, usually by modification of a native promoter containing one of the inducible elements by inserting the other of the inducible elements. In embodiments, additional metal responsive elements IR:Es) and/or glucocorticoid responsive elements (GREs) are provided to native promoters, particularly the hMT-IIA and MMTV-LTR promoters. One or more constitutive elements may be functionally disabled to provide the lower basal levels of gene expression.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: March 2, 1999
    Assignee: Connaught Laboratories Limited
    Inventors: Jorge Filmus, Michel Klein
  • Synthetic eukaryotic promoters containing two inducible elements
    Patent number: 5559027
    Abstract: Synthetic inducible eukaryotic promoters for the regulation of transcription of a gene achieve improved levels of protein expression and lower basal levels of gene expression. Such promoters contain at least two different classes of inducible elements, usually by modification of a native promoter containing one of the inducible elements by inserting the other of the inducible elements. In embodiments, additional metal responsive elements (MREs) and/or glucocorticoid responsive elements (GREs) are provided to native promoters, particularly the hMT-IIA and MMTV-LTR promoters. One or more constitutive elements may be functionally disabled to provide the lower basal levels of gene expression.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: September 24, 1996
    Assignee: Connaught Laboratories Limited
    Inventors: Jorge Filmus, Michel Klein