Patents by Inventor Jorge Heller

Jorge Heller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating nausea utilizing semi-solid delivery vehicle compositions comprising granisetron
    Patent number: 10357570
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: July 23, 2019
    Assignee: Heron Therapeutics, Inc.
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON
    Publication number: 20180339052
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: February 14, 2018
    Publication date: November 29, 2018
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • Methods of treating nausea utilizing semi-solid delivery vehicle compositions comprising granisetron
    Patent number: 9913910
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: March 13, 2018
    Assignee: Heron Therapeutics, Inc.
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20170007705
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: September 19, 2016
    Publication date: January 12, 2017
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • AMPHIPHILIC COPOLYMERS AND COMPOSITIONS CONTAINING SUCH POLYMERS
    Publication number: 20150099808
    Abstract: Amphiphilic copolymer, containing at least a hydrophilic chain segment (A) and a hydrophobic chain segment (B), wherein the hydrophilic chain segment (A) contains peptides and wherein the hydrophobic chain segment (B) contains acetal groups or orthoester groups. The hydrophilic chain segment (A) preferably contains glutamine/glutamic acid units or asparagines/aspartic acid units, making a biodegradable copolymer which can form a thermogel.
    Type: Application
    Filed: December 10, 2014
    Publication date: April 9, 2015
    Inventors: Jorge HELLER, Sebastien Jerome PIERRE, Mike Gerardus Wilhelmus DE LEEUW, Jeroen PIEPER
  • SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20140371187
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: April 15, 2014
    Publication date: December 18, 2014
    Applicant: Heron Therapeutics, Inc.
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • Semi-solid delivery vehicle and pharmaceutical compositions for delivery of granisetron
    Patent number: 8715710
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: May 6, 2014
    Assignee: Heron Therapeutics, Inc.
    Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
  • Semi-Solid Delivery Vehicle and Pharmaceutical Compositions
    Publication number: 20120283253
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: July 18, 2012
    Publication date: November 8, 2012
    Applicant: A.P. PHARMA, INC.
    Inventors: Steven Y. NG, Hui-Rong Shen, Jorge Heller
  • Process for preparing a semi-solid delivery vehicle comprising granisetron
    Patent number: 8252306
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: August 28, 2012
    Assignee: A.P. Pharma, Inc.
    Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
  • Methods of treating emesis utilizing semi-solid delivery pharmaceutical compositions comprising granisetron
    Patent number: 8252305
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: August 28, 2012
    Assignee: A.P. Pharma
    Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
  • Semi-solid delivery vehicle and pharmaceutical compositions for delivery of granisetron
    Patent number: 8252304
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: August 28, 2012
    Assignee: A. P. Pharma, Inc.
    Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
  • Process for Preparing a Semi-Solid Delivery Vehicle and Pharmaceutical Compositions
    Publication number: 20120041021
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: October 24, 2011
    Publication date: February 16, 2012
    Applicant: A.P. PHARMA, INC.
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • Methods of Treatment Utilizing Semi-Solid Pharmaceutical Compositions
    Publication number: 20120041020
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: October 24, 2011
    Publication date: February 16, 2012
    Applicant: A.P. PHARMA, INC.
    Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
  • AMPHIPHILIC COPOLYMERS AND COMPOSITIONS CONTAINING SUCH POLYMERS
    Publication number: 20110182813
    Abstract: Amphiphilic copolymer, containing at least a hydrophilic chain segment (A) and a hydrophobic chain segment (B), wherein the hydrophilic chain segment (A) contains peptides and wherein the hydrophobic chain segment (B) contains acetal groups or orthoester groups. The hydrophilic chain segment (A) preferably contains glutamine/glutamic acid units or asparagines/aspartic acid units, making a biodegradable copolymer which can form a thermogel.
    Type: Application
    Filed: September 18, 2008
    Publication date: July 28, 2011
    Applicant: NIRVANA'S TREE HOUSE B.V.
    Inventors: Jorge Heller, Sebastien Jerome Pierre, Mike Gerardus Wilhelmus De Leeuw, Jeroen Pieper
  • Semi-Solid Delivery Vehicle and Pharmaceutical Compositions
    Publication number: 20100010104
    Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: September 22, 2009
    Publication date: January 14, 2010
    Inventors: Steven Y. Ng, Hui-Rong Shen, Jorge Heller
  • PEG-Poly(Ortho Ester) Graft Copolymers and Pharmaceutical Compositions
    Publication number: 20090048151
    Abstract: This invention relates to graft copolymer delivery vehicles comprising a polyethyleneglycol-poly(ortho ester), and to controlled release pharmaceutical compositions comprising the delivery vehicle and an active agent. The graft copolymer delivery vehicles may be thermogels graft copolymers. The pharmaceutical compositions may be in the form of a topical, syringable, or injectable formulation for local controlled delivery of the active agent.
    Type: Application
    Filed: October 22, 2008
    Publication date: February 19, 2009
    Inventor: Jorge Heller
  • PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions
    Patent number: 7456213
    Abstract: This invention relates to graft copolymer delivery vehicles comprising a polyethyleneglycol-poly(ortho ester), and to controlled release pharmaceutical compositions comprising the delivery vehicle and an active agent. The graft copolymer delivery vehicles may be thermogels graft copolymers. The pharmaceutical compositions may be in the form of a topical, syringable, or injectable formulation for local controlled delivery of the active agent.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: November 25, 2008
    Assignee: A.P. Pharma, Inc.
    Inventor: Jorge Heller
  • Base-Stabilized Polyorthoester Formulations
    Publication number: 20080015210
    Abstract: A stabilized semi-solid delivery vehicle contains a polyorthoester and an excipient, and a pharmaceutical composition contains an active agent, optionally a stabilizing agent, and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: July 16, 2007
    Publication date: January 17, 2008
    Inventors: Devang Shah, John Barr, Brian Baxter, Jorge Heller
  • Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
    Publication number: 20070265329
    Abstract: A pharmaceutical composition for the sustained release of an effective amount of a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist for the prevention, reduction or alleviation of acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a course of emetogenic chemotherapy, wherein the composition is administered by subcutaneous injection, the composition comprising a 5-HT3 receptor antagonist, a semi-solid delivery vehicle and a pharmaceutically acceptable liquid excipient; wherein the composition, when administered in a single dosage, provides a controlled release of the 5-HT3 receptor antagonist and prolonging the release of the 5-HT3 receptor antagonist that tracks the profile of the incidence of vomiting.
    Type: Application
    Filed: May 12, 2006
    Publication date: November 15, 2007
    Inventors: Shah Devang, John Barr, Brian Baxter, Jorge Heller
  • Base-stabilized polyorthoester formulations
    Publication number: 20070264339
    Abstract: A stabilized semi-solid delivery vehicle contains a polyorthoester and an excipient, and a pharmaceutical composition contains an active agent, optionally a stabilizing agent, and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.
    Type: Application
    Filed: December 1, 2006
    Publication date: November 15, 2007
    Inventors: Devang Shah, John Barr, Brian Baxter, Jorge Heller