Abstract: Systems and methods for biomonitoring and personalized healthcare are disclosed herein. In some embodiments, a biomonitoring and healthcare guidance system is configured to generate personalized self-care recommendations (e.g., recommendations relating to sleep, exercise, diet, etc.) to guide a. patient in effectively managing and/or improving a chronic condition (e.g., diabetes, pre-diabetes, hypertension, hyperlipidemia, etc.). The system can continuously or periodically update and/or adapt the self-care recommendations (e.g., based on data from the particular patient as well as data from a plurality of other patients). The system can guide individuals toward self-care changes that are likely to improve their chronic health conditions, support them in making those changes, and adapt and/or update continuously over time.