Abstract: A prosthetic heart valve that is at least partially coated with an enhancement layer, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement layer. One type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: A medical device delivery arrangement that includes a medical device, a delivery system, and a filter arrangement. The delivery system includes a catheter and a guide shaft that are configured to move independently from one another. The filter arrangement is configured to move between a constrained-collapsed position and a deployed position. The filter arrangement includes a filter frame and a filter material. The guide shaft is moveable relative to the filter arrangement between a constraining and non-constraining position. The filter arrangement is positioned in the constrained-collapsed position when the guide shaft is in the constraining position due to the guide shaft being positioned partially or fully over the filter arrangement. The filter arrangement is in the deployed position when the guide shaft is in the non-constraining position due the guide shaft being positioned distal to the filter arrangement.

Abstract: Inflation adjustment attachment devices, systems, and methods for accurately deploying a medical device. The inflation adjustment attachment devices, systems, and methods are configured to allow for the controlled increase of the balloon volume during inflation of the prosthetic heart valve, and thereafter without having to deflate the balloon, enable an additional volume to be added to the inflation device.

Abstract: A device and method of inhibiting and preventing damage to leaflets during the crimping of a prosthetic valve, and/or facilitating the folding of the leaflets during the crimping of a prosthetic valve.

Abstract: The present invention describes a system that uses ultrasonic waves to transfer energy and data, enabling for the control and recharging of a cardiac assist device. Data and energy transfer are accomplished using pulsed ultrasonic waves. The use of ultrasonic waves allows for wireless transcutaneous energy transfer to power the cardiac assist device pump in absence of a driveline, reducing complications associated with driveline infections and improving patient quality of life.

Abstract: A prosthetic heart valve that is at least partially coated with an enhancement layer, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement layer. One type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: A clinical bedside system facilitates care for complex care patients. The system can include a medical device having a biosensor with an inert substrate and a working electrode, a counter electrode, and a reference electrode deposited thereon. The working electrode can have an antifouling membrane thereover to which a capture antibody is immobilized. The capture antibody can be configured to capture a biomarker between it and a detection antibody, thereby sandwiching the infection biomarker between the antibodies for a detectable redox reaction between an enzyme conjugated to the detection antibody and the working electrode. The counter electrode can complete completes an electrical circuit including the working electrode. The reference electrode can be operably connected to the electrical circuit. The reference electrode can be configured to provide a reference point against which changes in potential at the working electrode can be measured, for example, with a potentiostat.

Abstract: A system and process are provided for identification, determination, characterization, and/or quantification of groundwater. According to an embodiment, the system includes an information input unit, an information packaging and process unit, and an information output unit. The information input unit includes sensors, modules, and microcontrollers configured for data acquisition relating to the groundwater. The information packaging and processing unit is configured to utilize software, AI, Blockchain, and/or Smart Contracts. The information output unit is configured to output information through applications, web platforms, reports, and/or alerts.

Abstract: Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.

Abstract: A prosthetic heart valve that is at least partially coated with an enhancement coating, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement coating. One type of enhancement coating that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: A prosthetic heart valve that is at least partially coated with an enhancement coating, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement coating. One type of enhancement coating that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: A delivery handle arrangement and system that facilitates the delivery of an expandable medical device to a treatment site, and wherein the delivery handle arrangement includes a housing having an inner core that extends linearly between a proximal end and a distal end of the housing, and wherein the inner core receives a flexible catheter and a balloon catheter that is disposed coaxially within the flexible catheter; an adjustment mechanism that is configured to control a position of the balloon catheter relative to the flexible catheter, and wherein the adjustment mechanism includes a control knob that has a plurality of threads; and a threaded shaft that is configured to translate linearly within the housing; and a switch that is configured to lock or unlocked the adjustment mechanism.

Abstract: A medical device that is at least partially coated with an enhancement layer, and a method for inserting the medical device a patient. One non-limiting type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: A prosthetic heart valve that is at least partially coated with an enhancement layer, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement layer. One type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: Systems and methods for wireless deep brain stimulation using ultrasonic waves. Implantable device(s) for intracranial use within a subject may comprise at least one stimulation means, one or more circuits for collecting system data, a receiver, and a transmitter for communications using ultrasonic waves. A wearable controller external to the subject, the wearable controller configured to: communicate with the implantable device(s) using the ultrasonic waves and obtain the system data, analyze the system data to determine whether the subject is experiencing or is expected to experience an adverse medical condition, and communicate with the implantable device(s) using the ultrasonic waves to apply a stimulation to treat the adverse medical condition. The system may be used to treat Parkinson's Disease, for example.

Abstract: Described herein are methods, devices, and support structures for assembling optical fibers in catheter tips and facilitating alignment and structural support. A method for assembling a plurality of optical fibers and lenses in a support structure for an ablation catheter includes providing a support structure with a proximal end, a body, and a distal end, the distal end including a plurality of alignment orifices or slits. A plurality of optical fibers are threaded through the alignment orifices or slits, such that each optical fiber is threaded through a corresponding alignment orifice or slit. An adhesive material is applied at each alignment orifice or slit to secure the optical fibers, and the plurality of optical fibers are then cleaved at the distal end to remove portions of the fibers extending out of the distal end. Finally, a lens is attached to each of the ends of the plurality of optical fibers.

Abstract: Described herein are systems and methods for performing optical signal analysis and lesion predictions in ablations. A system includes a catheter coupled to a plurality of optical fibers via a connector that interfaces with a computing device. The computing device includes a memory and a processor configured to receive optical measurement data of a portion of tissue from the catheter. The processor identifies one or more optical properties of the portion of tissue by analyzing the optical measurement data and determines a time of denaturation of the portion of tissue based on the one or more optical properties. A model is created to represent a correlation between lesion depths and ablation times using the time of denaturation, the one or more optical properties, and the predetermined period of time. A predicted lesion depth for a predetermined ablation time is generated using the model.

Abstract: Wirelessly networked systems of implantable and non-implantable medical devices with networking protocols, software, and hardware that allow for communications and energy transfer between different the medical devices (free standing, implants and wearables) using ultrasonic waves. The networks and methods of use are used to construct cardiac pacing, deep brain stimulation, and neurostimulation networks based on ultrasonic wide band technology.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.