Abstract: A sealable container for preservation of a biological sample is provided. The sealable container includes a cap and an elongate body. The cap has a proximal open end and a distal end with a lumen extending from the proximal open end to the distal end. The elongate body extends from a handle portion to a specimen portion, where the specimen portion is configured to receive a biological sample thereon. The elongate body further includes a closure portion disposed between the handle portion and the specimen portion, where the closure portion is configured to make surface to surface contact with the cap when the specimen portion of the elongate body is fully inserted within the lumen of the cap. At least one of an inner surface of the cap and an outer surface of the elongate body includes a textured area with a textured surface finish.

Abstract: A device for permeation of a biological material may include a lower portion and an upper portion configured to be releasably coupled to the lower portion. The lower portion may include a groove configured to receivingly support a biological material. The lower portion and the upper portion may be coupled such that a first reservoir and a second reservoir are formed collectively by the lower portion and the upper portion. The first reservoir, the second reservoir, and the groove may be in fluid communication with each other.

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use thereof, and methods of manufacturing. In one embodiment a strain relief member may include a support having a first end with a first outer diameter, a second end having a second outer diameter, an inner surface facing a support lumen that extends axially through the support along a longitudinal axis, and an outer surface opposite to the inner surface. An embodiment may also include an overlay coupled to a portion of the outer surface of the support, where the overlay comprises a first material and the support comprises a second material, and the first material is more flexible than the second material. A liner may be disposed in a portion of the support lumen and a first connector disposed over a portion of the support.

Abstract: A sealable container for preservation of a biological sample is provided. The container includes a cap comprising a proximal open and a lumen and an elongate body that extends from a handle portion to a specimen portion. A closure portion is disposed between the handle portion and the specimen portion, wherein the closure portion is configured to make surface to surface contact with the cap when the specimen portion is fully inserted within the lumen. The closure portion comprises an outer diameter that gradually decreases in a direction from the handle portion to the specimen portion. The specimen portion comprises a scooped portion where a distance between the upper surface and the lower surface is less than distances between the upper surface and the lower surface along remaining portions of the specimen portion, wherein the scooped portion is spaced proximally from a distal tip of the specimen portion.

Abstract: A device for permeation of a biological material may include a lower portion and an upper portion configured to be releasably coupled to the lower portion. The lower portion may include a groove configured to receivingly support a biological material. The lower portion and the upper portion may be coupled such that a first reservoir and a second reservoir are formed collectively by the lower portion and the upper portion. The first reservoir, the second reservoir, and the groove may be in fluid communication with each other.

Abstract: A device for culturing specimens may include a housing and a conveyor disposed within the housing, where the conveyor is translatable in vertical directions. The device may further include a plurality of plate holders disposed along a length of the conveyor, such that each plate holder of the plurality of plate holders can be moved to different positions along the length of the conveyor by a translation of the conveyor in the vertical directions. The device may further include an isolation chamber movable between a first position and a second position. The isolation chamber may include an opening and a door. The isolation chamber may be configured such that when the isolation chamber is in the second position, a first plate holder of the plurality of plate holders is isolated from a rest of the housing by the isolation chamber.

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use thereof, and methods of manufacturing. In one embodiment a strain relief member may include a support having a first end with a first outer diameter, a second end having a second outer diameter, an inner surface facing a support lumen that extends axially through the support along a longitudinal axis, and an outer surface opposite to the inner surface. An embodiment may also include an overlay coupled to a portion of the outer surface of the support, where the overlay comprises a first material and the support comprises a second material, and the first material is more flexible than the second material. A liner may be disposed in a portion of the support lumen and a first connector disposed over a portion of the support.

Abstract: The present embodiments provide strain relief members for a medical device delivery system, methods of use, and methods of manufacturing. In one embodiment, a medical device delivery system may include a body member with a first end having a first outer diameter, a second end having a second outer diameter, an inner surface facing a lumen that extends axially through the body member along a longitudinal axis, and an outer surface opposite to the inner surface. The embodiment also includes a threaded first connector at the first end of the body member. The outer surface of the body member may include a plurality of depressions. The body member may include a first material. The first connector may include a second material. The first material is more flexible than the second material. A portion of the outer surface of the body member may cover a portion of the first connector.

Abstract: A device for guiding an elongate body into a channel of a scope may include a main body extending between a proximal end portion and a distal end portion and a lumen extending through the main body. The device may be slidably attached onto the elongate body such that the elongate body may be threaded through the lumen of the device, out of the distal end portion of the main body of the device, and into the channel of the scope. When a distal end of the elongate body reaches a desired location inside the channel, the device may be moved along the elongate body from a first position to a second position, where the device may be releasably coupled with respect to the elongate body.

Abstract: A system for passive permeation of a biological material is disclosed. The system may include a main channel extending between an upper portion and a lower portion; a main reservoir connected to the upper portion of the main channel and in fluid communication with the main channel; a bottom reservoir connected to the lower portion of the main channel and in fluid communication with the main channel; at least one secondary channel disposed in at least one position between the upper portion and the lower portion of the main channel such that fluid communication is established in the at least one position between the at least one secondary channel and the main channel; and at least one secondary reservoir respectively connected to an upper portion of each of the at least one secondary channel and in fluid communication with the respective at least one secondary channel.

Abstract: A sealable container for preservation of a biological sample is provided. The container includes a cap comprising a proximal open and a lumen and an elongate body that extends from a handle portion to a specimen portion. A closure portion is disposed between the handle portion and the specimen portion, wherein the closure portion is configured to make surface to surface contact with the cap when the specimen portion is fully inserted within the lumen. The closure portion comprises an outer diameter that gradually decreases in a direction from the handle portion to the specimen portion. The specimen portion comprises a scooped portion where a distance between the upper surface and the lower surface is less than distances between the upper surface and the lower surface along remaining portions of the specimen portion, wherein the scooped portion is spaced proximally from a distal tip of the specimen portion.

Abstract: Aspects of the invention provides an imaging mini-scope, an attachment clip and a system including these components. Another aspect provides a method to using the imaging scope and attachment clip for an endoscopic procedure. In one embodiment, the mini-scope includes an elongated body having an attached jacket extending to its proximal end to its distal end. The jacket includes a longitudinal track extending from the distal end to the proximal end and defining a lumen having a restricted opening on the external surface of the jacket. The attachment clip includes a head portion that is sized and shaped to fit in the lumen and to slidably engage the longitudinal track.

Abstract: A kit for performing long term storage of biological matter is provided. The kit includes an elongate rod, extending between opposed first and second ends, and at least one holding point disposed upon the rod between the first and second ends, the holding point comprising a recess defined within a wall. A cryovial with an internal volume is configured to receive a biological sample therein, the cryovial comprising at least one finger that extends radially outward from an outer circumference thereof, wherein the finger is configured to releaseably mate with the at least one holding point upon the rod.

Abstract: A container or vial for the cryopreservation and/or vitrification and storage of a biological sample, including cellular samples and embryos is described. The container comprises a sealable closure that isolates a biological sample held in the container lumen from the external environment and is suitable for storage of the sample in liquid nitrogen. Methods for introducing and sealing biological samples within the container for cryopreservation and/or vitrification and storage are also described.

Abstract: A kit for performing long term storage of biological matter is provided. The kit includes an elongate rod, extending between opposed first and second ends, and at least one holding point disposed upon the rod between the first and second ends, the holding point comprising a recess defined within a wall. A cryovial with an internal volume is configured to receive a biological sample therein, the cryovial comprising at least one finger that extends radially outward from an outer circumference thereof, wherein the finger is configured to releaseably mate with the at least one holding point upon the rod.

Abstract: A kit for performing long term storage of biological matter is provided. The kit includes an elongate rod, extending between opposed first and second ends, and at least one holding point disposed upon the rod between the first and second ends, the holding point comprising a recess defined within a wall. A cryovial with an internal volume is configured to receive a biological sample therein, the cryovial comprising at least one finger that extends radially outward from an outer circumference thereof, wherein the finger is configured to releasably mate with the at least one holding point upon the rod.

Abstract: A device for the cryopreservation and/or vitrification of a biological sample in a freezing medium is described. The device preferably comprises a bath for receiving a vessel containing a biological sample in liquid-phase nitrogen. In one example, the bath includes a first member extending generally vertically from a bottom wall portion which divides the interior chamber of the bath into a first sub-chamber adapted for receiving a volume of cryogenic freezing medium and a second or overflow sub-chamber adapted to receive freezing medium from the first sub-chamber. A second member extends generally horizontally between the sidewall portions of the bath and includes at least one opening for receiving a biological sample-containing vessel(s). A kit including a cryogenic storage device and a vessel is also described.

Abstract: A kit for performing long term storage of biological matter is provided. The kit includes an elongate rod, extending between opposed first and second ends, and at least one holding point disposed upon the rod between the first and second ends, the holding point comprising a recess defined within a wall. A cryovial with an internal volume is configured to receive a biological sample therein, the cryovial comprising at least one finger that extends radially outward from an outer circumference thereof, wherein the finger is configured to releasably mate with the at least one holding point upon the rod.

Abstract: A container or vial for the cryopreservation and/or vitrification and storage of a biological sample, including cellular samples and embryos is described. The container comprises a sealable closure that isolates a biological sample held in the container lumen from the external environment and is suitable for storage of the sample in liquid nitrogen. Methods for introducing and sealing biological samples within the container for cryopreservation and/or vitrification and storage are also described.

Abstract: A device for the cryopreservation and/or vitrification of a biological sample in a freezing medium is described. The device preferably comprises a bath for receiving a vessel containing a biological sample in liquid-phase nitrogen. In one example, the bath includes a first member extending generally vertically from a bottom wall portion which divides the interior chamber of the bath into a first sub-chamber adapted for receiving a volume of cryogenic freezing medium and a second or overflow sub-chamber adapted to receive freezing medium from the first sub-chamber. A second member extends generally horizontally between the sidewall portions of the bath and includes at least one opening for receiving a biological sample-containing vessel(s). A kit including a cryogenic storage device and a vessel is also described.