Abstract: A method and system desulfurizes fuel produced from pyrolysis of waste tires and includes hydroprocessing tire pyrolysis oil to desulfurize the tire pyrolysis oil and obtain a hydroprocessed pyrolysis oil. The hydroprocessed oil is distilled into at least two environmentally fuel products selected from the group consisting of kerosene, naphtha, fuel oil, fuel and diesel. By combining hydroprocessing with distillation, and advantageously recycling byproducts, the methods of this disclosure allow for conversion of waste tires into fuel in a manner that is commercially viable and sustainable.

Abstract: The present disclosure provides complexes comprising a cationic oligosaccharide and an RNA, wherein the cationic oligosaccharide comprises a plurality of cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6, and a ratio of N/P in the complex is less than 20:1

Abstract: The present disclosure provides complexes comprising: i) a cationic oligosaccharide comprising one or more cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6; ii) a surfactant; and iii) one or more additives selected from: a sterol, a helper lipid, an immunomodulator, and a targeting molecule; and uses thereof.

Abstract: The present invention relates to an oral composition of ciclopirox or a derivate thereof which do not exhibit gastrointestinal toxicity and comprises a therapeutically effective amount of ciclopirox, tocopherol and alginate or their derivates.

Abstract: An electroencephalogram measurement device (1), comprising a support (10) on which the following components are attached and/or integrated: at least one electrode (2) for measuring EEG signals from a user (U); and at least one shielded cable (3), electrically connected to the at least one electrode (2), for transporting the EEG signals to an electrical signal amplifier (A); wherein the at least one electrode (2) and the at least one shielded cable (3) are made of threads and/or textiles. Process for manufacturing an electroencephalogram measurement device (1) whose sensor layer is partially or integrally made with threads and/or textiles.

Abstract: The present disclosure provides compositions comprising an oligosaccharide of formula (I), wherein said compositions are useful for delivery of certain agents, including, for example, nucleic acids.

Abstract: The present disclosure provides a compound of formula I, as well as complexes and compositions comprising a compound of formula I, wherein said compositions and complexes are useful for delivery of certain agents, including, for example, nucleic acids.

Abstract: The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.

Abstract: A method and system desulfurizes fuel produced from pyrolysis of waste tires and includes hydroprocessing tire pyrolysis oil to desulfurize the tire pyrolysis oil and obtain a hydroprocessed pyrolysis oil. The hydroprocessed oil is distilled into at least two environmentally fuel products selected from the group consisting of kerosene, naphtha, fuel oil, fuel and diesel. By combining hydroprocessing with distillation, and advantageously recycling byproducts, the methods of this disclosure allow for conversion of waste tires into fuel in a manner that is commercially viable and sustainable.

Abstract: This disclosure provides a method and system for desulfurizing fuel produced from pyrolysis of waste tires including adsorbing one or more polar sulfur molecules from the tire pyrolysis oil with a regenerable adsorbent, distilling the tire pyrolysis oil to separate the tire pyrolysis oil into at least two fuel products and regenerating and reusing the regenerable adsorbent material. By combining adsorption with distillation, and advantageously recycling byproducts, the methods of this disclosure allow for conversion of waste tires into fuel in a manner that is commercially viable and sustainable.

Abstract: The present invention relates to compositions comprising RNA, preferably messenger RNA (mRNA), more preferably self-amplifying RNA (saRNA), and polymers, in particular cationic polymers, such as polyethylenimine (PEI), poly-L-Lysin (PEL), polyvinylamine (PVA) or polyallylamine (PAA), where individual RNA molecules are present in solution. In the formulations, the RNA is preferentially present in the form of monomers, dimers, timers or oligomers, but not as aggregates comprising a large number of RNA molecules per aggregate, in particular large polyplex nanoparticles. The formulations display improved transfection efficacy and they can be used for delivery of RNA to a subject, where they have an improved dose response relationship in comparison to formulations where large aggregates in the form of polyplex nanoparticles are present.

Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.

Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.

Abstract: The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine. The RNA may encode a protein of interest, such as a pharmaceutically active protein. Furthermore, the present invention relates to pharmaceutical products, comprising said RNA polyplex formulations for parenteral application to humans or to animals. The present invention relates as well to manufacturing of such pharmaceutical products, comprising, optionally, steps of sterile filtration, freezing and dehydration.

Abstract: Certain embodiments provide systems and methods for determining light source characteristics from an image. An image having pixels is received that is affected by a light source. A silhouette boundary is received. The image may be filtered to decrease diffuse reflectivity. The presence of light sources is estimated by identifying a local maxima pixel around the silhouette boundary. The local maxima pixel may be associated with the light source. A slant angle that is associated with the light source is estimated using the silhouette boundary. A tilt angle associated with the light source is estimated using the slant angle and local maxima pixel intensity. The relative intensity of each light source may be determined. The ambient light intensity of the image may be determined. The characteristics, such as the slant angle and tilt angle, may be provided to a user.

Abstract: Certain embodiments provide systems and methods for determining light source characteristics from an image. An image having pixels is received that is affected by a light source. A silhouette boundary is received. The image may be filtered to decrease diffuse reflectivity. The presence of light sources is estimated by identifying a local maxima pixel around the silhouette boundary. The local maxima pixel may be associated with the light source. A slant angle that is associated with the light source is estimated using the silhouette boundary. A tilt angle associated with the light source is estimated using the slant angle and local maxima pixel intensity. The relative intensity of each light source may be determined. The ambient light intensity of the image may be determined. The characteristics, such as the slant angle and tilt angle, may be provided to a user.

Abstract: Certain embodiments provide systems and methods for determining light source characteristics from an image. An image having pixels is received that is affected by a light source. A silhouette boundary is received. The image may be filtered to decrease diffuse reflectivity. The presence of light sources is estimated by identifying a local maxima pixel around the silhouette boundary. The local maxima pixel may be associated with the light source. A slant angle that is associated with the light source is estimated using the silhouette boundary. A tilt angle associated with the light source is estimated using the slant angle and local maxima pixel intensity. The relative intensity of each light source may be determined. The ambient light intensity of the image may be determined. The characteristics, such as the slant angle and tilt angle, may be provided to a user.

Abstract: A downhole waterflood regulator installs in a side pocket mandrel to regulate fluid flow in a waterflood completion. The regulator has an internal piston and can have a check dart. The piston and check dart regulate fluid flow within the regulator's housing. Packings on the regulator's housing packoff the mandrel's ports that communicate with a surrounding annulus. When initially installed in the mandrel, a blanking plug on the regulator's latch prevents fluid flow through the regulator so that the regulator acts as a dummy valve and allows operators to set and test packers or perform other operations. To begin the waterflood operation, operators use a slickline to remove the blanking plug disposed in the latch. With the plug removed, fluid communicated from the tubing string can pass through the ported latch and into the regulator where the piston and check dart regulate the fluid flow out to the annulus.

Abstract: A downhole waterflood regulator installs in a side pocket mandrel to regulate fluid flow in a waterflood completion. The regulator has an internal piston and can have a check dart. The piston and check dart regulate fluid flow within the regulator's housing. Packings on the regulator's housing packoff the mandrel's ports that communicate with a surrounding annulus. When initially installed in the mandrel, a blanking plug on the regulator's latch prevents fluid flow through the regulator so that the regulator acts as a dummy valve and allows operators to set and test packers or perform other operations. To begin the waterflood operation, operators use a slickline to remove the blanking plug disposed in the latch. With the plug removed, fluid communicated from the tubing string can pass through the ported latch and into the regulator where the piston and check dart regulate the fluid flow out to the annulus.

Abstract: Certain embodiments provide systems and methods for determining light source characteristics from an image. An image having pixels is received that is affected by a light source. A silhouette boundary is received. The image may be filtered to decrease diffuse reflectivity. The presence of light sources is estimated by identifying a local maxima pixel around the silhouette boundary. The local maxima pixel may be associated with the light source. A slant angle that is associated with the light source is estimated using the silhouette boundary. A tilt angle associated with the light source is estimated using the slant angle and local maxima pixel intensity. The relative intensity of each light source may be determined. The ambient light intensity of the image may be determined. The characteristics, such as the slant angle and tilt angle, may be provided to a user.