Abstract: The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.

Abstract: The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.

Abstract: The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.

Abstract: The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.

Abstract: The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding the nucleic acids and proteins listed in FIG. 7, which are involved in modulation of lymphocyte activation and migration, e.g., A-raf-1, Lck, Zap70, Syk, PLC?1, PAG, SHP/PTP1C, CSK, nucleolin, SLAP, PAK2, TRAC1, TCPTP/PTPN2, EDG1, IL10-R?, integrin?2, Enolase 1a, PRSM1, CLN2, P2X5b, 6PFKL, DUSP1, KIAA0251, GG2-1, GRB7, SH2-B, STAT1, TCF19, HFP101S, RERE, SudD, Ku70, SCAMP2, Fibulin-5, KIAA1228, Est from clone 2108068, vimentin, filamin A ?, centractin ?, moesin, TIMP3, and RNH.

Abstract: The present invention relates to regulation of T lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding GRB7, which is involved in modulation of T lymphocyte activation and TCR signaling. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation and TCR signaling via modulation of GRB7; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.

Abstract: The present invention relates to regulation of T cell activation. More particularly, the present invention is directed to nucleic acids encoding alpha 2 integrin. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, siRNA, antisense nucleic acids, and ribozymes, that modulate T cell activation via modulation of alpha 2 integrin and alpha 2 integrin-related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to autoimmune disease and tissue and organ transplant.

Abstract: The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.

Abstract: The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding TRAC1, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of TRAC1; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.

Abstract: The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.

Abstract: An interlocking block for constructing walls without mortar at bed joints includes an inner wall, an outer wall, and a web arrangement connecting the walls, wherein upper and lower surfaces of the block when in use are formed in contact with walls of a mold, and the block is slipped from the mold in a direction parallel to the mold walls. Interlocking recesses and ridges are formed in one piece with the walls of the block. The web is minimal in cross-sectional area and is positioned at one end of the block and between the top and bottom to create large empty volumes defining vertical and horizontal passages. The block can include one or more intermediate walls parallel to the inner and outer walls and additional webs to connect the intermediate walls to the inner and outer walls.

Abstract: An interlocking block for constructing walls without mortar at bed joints includes an inner wall, an outer wall, and a web arrangement connecting the walls, wherein upper and lower surfaces of the block when in use are formed in contact with walls of a mold, and the block is slipped from the mold in a direction parallel to the mold walls. Interlocking recesses and ridges are formed in one piece with the walls of the block. The web is minimal in cross-sectional area and is positioned at one end of the block and between the top and bottom to create large empty volumes defining vertical and horizontal passages. The block can include one or more intermediate walls parallel to the inner and outer walls and additional webs to connect the intermediate walls to the inner and outer walls.

Abstract: A horizontal diaphragm for the generation of floor and roof structures includes a plurality of construction units arranged in rows and integrated joists by clip ties, wherein a load transferring material fills spaces between adjacent construction units in a row, both transversely and longitudinally. Each construction unit includes a lip projecting toward an adjacent unit in the row and defining with the other construction unit a space for receiving the filler material. The clip ties are anchored in the joists and are movable from a position obstructing the placement of additional construction units on the joists to a position integrating the previous construction unit with the joists. The joists comprise U-shaped troughs filled with grout in which the clip ties are anchored at spaced locations. The structure defining the trough can be monolithic or can comprise a plurality of discrete units placed in alignment and connected by reinforcing bars.

Abstract: A construction unit includes weep openings through a front wall, side walls, and a center web, and at least one slot extending parallel to a rear wall to receive a flashing member, the slot being defined at least partially by the rear wall. An insert member having an insect screen is positioned in each of the weep openings of the front wall.

Abstract: The biaxial CM casting apparatus utilizes one or more main mold cores having an automatically extensible and retractable plunger or like structure extending laterally into the mold cavity from the one or more main mold cores along an axis substantially orthogonal to the axis of casting during certain selected phases of the CM casting process to form one or more openings or other structural changes in the casted concrete which openings or changes extend in the direction of a second axis normal to the casting axis.

Abstract: A CM block machine for casting masonry blocks includes a mold cavity formed between a mold box and a mold core containing one or more plungers selectively extending laterally into the cavity along a second axis which is normal to the axis of casting so as to form openings extending through portions of the block in the direction of the second axis. The plunger(s) is disposed in a cartridge housing contained within the mold core. An oversized vibrating ring wiper mounted in the cartridge housing engages the external periphery of the plunger to prevent CM material from entering the cartridge during plunger retraction. The plunger includes an annular relief chamber formed in a side wall thereof to provide an additional volume of air from within the cartridge to an air passage communicating with the plunger end face to prevent vacuum from impeding plunger retraction.

Abstract: Interfitting modular construction units include alternating plateaus and recesses which interfit with one another to form walls without mortar. Drainage grooves are defined in the units, bevels are provided on the perimeter of the front and back to give a brickface appearance to the wall, and shear notches are defined just behind the front and back, and the units are devoid of surfaces facing toward one side. Special corner units are provided, along with cap units having transverse bores. Retaining walls and fence walls employing the units at integral footings defined by the units and drainage passages defined by cooperating drainage grooves. Piers can be provided to permit the construction of higher walls.

Abstract: A roof paver element includes a plurality of ribs projecting from a planar body portion, the ribs terminating in bottom surfaces having rounded longitudinal boundaries. The ribs are connected to the planar body portion and to one another by fillets. Sides of the planar body portions include depressions which form pressure equalization chambers with the sides of the body portions of adjacent roof paver elements in a roof system to hinder the development of air pressure differentials between the region above the roof paver elements and the spaces below the planar body portions.

Abstract: Methods for biaxially (or triaxially) casting concrete masonry ("CM") products like CM blocks which have twin cavities formed by a pair of face shells and three webs interconnecting same with the twin cavities extending in the direction of the axis of casting of the CM block include using in the mold cavity one or more main mold cores which incorporate structure for extending and retracting a plunger or the like to provide one or more temporary mold cores laterally extending into the mold cavity from one or more main mold cores along a second axis which is normal to the axis of casting during certain selected phases of the CM casting process so as to form openings extending through one or more webs in the direction of the second axis.