Abstract: The present disclosure includes substituted 1-aryl-1?-heteroaryl compounds, substituted 1,1?-biheteroaryl compounds, analogues thereof, and compositions comprising the same. Such compounds and analogues comprises compounds of formula (I). In one aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent cancer in a patient.

Abstract: The present invention includes in one aspect substituted 2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient.

Abstract: A method may include storing, using a data management application on a user device, personal data that is associated with a user and a first data variable. The method may further include obtaining, from a requesting application and by the data management application, a data request for a second data variable. The method may further include determining, by the data management application, whether the first data variable associated with the personal data matches the second data variable associated with the data request. The method may further include transmitting, by the data management application and in response to determining that the first data variable matches the second data variable, the personal data to various intermediary nodes. One intermediary node among the intermediary nodes may transmit the personal data to the requesting application using a distributed ledger.

Abstract: The present disclosure includes novel substituted cyclopropyl-2,2?-bipyrimidinyl compounds, and compositions comprising the same. In certain embodiments, the compounds of the disclosure can be used to treat or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) infection in a patient.

Abstract: The present disclosure includes substituted isoindolinyl 2,2?-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.

Abstract: A method of designing a target combustible tobacco product, the method comprising receiving respective values for a plurality of input parameters (101); calculating respective values for a plurality of design parameters (130) for the combustible tobacco product based on the received values for the plurality of input parameters, and providing the calculated values as an output. The plurality of design parameters comprise at least two parameters selected from: a tobacco blend composition; tar, nicotine and carbon monoxide deliveries; a smoke sensory attribute; a number of puffs associated with the combustible tobacco product; combustible tobacco product dimensions; tobacco weight; tobacco rod and/or filter density; tobacco rod and/or filter firmness; open and/or closed combustible tobacco product pressure drop; filter pressure drop; cigarette paper porosity; and ventilation level.

Abstract: The present invention includes substituted polycyclic carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient.

Abstract: The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.

Abstract: The present disclosure includes substituted 2,2?-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.

Abstract: The present invention includes in one aspect substituted 2-oxo-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient.

Abstract: The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.

Abstract: The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection.

Abstract: The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection.