Patents by Inventor Jorge R. Barrio
Jorge R. Barrio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10626083Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.Type: GrantFiled: June 28, 2019Date of Patent: April 21, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jie Liu, Jorge R. Barrio
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Publication number: 20190322616Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.Type: ApplicationFiled: June 28, 2019Publication date: October 24, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jie Liu, Jorge R. Barrio
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Patent number: 10377701Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.Type: GrantFiled: November 8, 2017Date of Patent: August 13, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jie Liu, Jorge R. Barrio
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Patent number: 10357217Abstract: A method of using PET imaging includes using PET images obtained using a radiotracer for the determination of the progressive course of regional brain PET activities for a progressive neurodegenerative disease (e.g., MCI, AD, and CTE). The method may be used for the automatic staging of neurodegenerative disease for a particular patient/subject based on regional intensity and spatial patterns of the brain signals measured by PET imaging. The method may also be used to diagnose or classify the disease of a patient among multiple possibilities based on PET imaging profiles (e.g., for separating or distinguishing CTE from AD).Type: GrantFiled: October 18, 2017Date of Patent: July 23, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sung-Cheng Huang, Koon-Pong Wong, Gary W. Small, Jorge R. Barrio
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Publication number: 20180127355Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.Type: ApplicationFiled: November 8, 2017Publication date: May 10, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jie Liu, Jorge R. Barrio
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Publication number: 20180103921Abstract: A method of using PET imaging includes using PET images obtained using a radiotracer for the determination of the progressive course of regional brain PET activities for a progressive neurodegenerative disease (e.g., MCI, AD, and CTE). The method may be used for the automatic staging of neurodegenerative disease for a particular patient/subject based on regional intensity and spatial patterns of the brain signals measured by PET imaging. The method may also be used to diagnose or classify the disease of a patient among multiple possibilities based on PET imaging profiles (e.g., for separating or distinguishing CTE from AD).Type: ApplicationFiled: October 18, 2017Publication date: April 19, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sung-Cheng Huang, Koon-Pong Wong, Gary W. Small, Jorge R. Barrio
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Patent number: 9481705Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: GrantFiled: November 13, 2015Date of Patent: November 1, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen
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Publication number: 20160130295Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: ApplicationFiled: November 13, 2015Publication date: May 12, 2016Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen
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Patent number: 9211520Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: GrantFiled: December 24, 2014Date of Patent: December 15, 2015Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen
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Publication number: 20150329583Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: ApplicationFiled: December 24, 2014Publication date: November 19, 2015Inventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen
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Patent number: 8951480Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: GrantFiled: August 19, 2009Date of Patent: February 10, 2015Assignee: The Regents of the University of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark A. Eddings, Clifton Kwang-Fu Shen
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Patent number: 8845999Abstract: Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with 18F, 123I, or 124I, or free hexoses radiolabeled with 18F, 123I, or 124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.Type: GrantFiled: May 23, 2006Date of Patent: September 30, 2014Assignee: The Regents of the University of CaliforniaInventors: Ernest M. Wright, Jorge R. Barrio, Bruce A. Hirayama, Vladimir Kepe
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Publication number: 20140271474Abstract: Radiolabeled tracers for binding to sodium/glucose cotransporters (SGLTs), and their synthesis, are provided. The tracers are high-affinity inhibitors of SGLTs, glycosides labeled with radioactive halogens. Also provided are in vivo and in vitro techniques for using the tracers as analytical tools to study the biodistribution and regulation of SGLTs in health and disease, and to evaluate therapeutic interventions. The ability to monitor radiolabel tracer disposition in real time enables the design of new SGLT inhibitors with lower metabolism and higher efficiency.Type: ApplicationFiled: June 14, 2012Publication date: September 18, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ernest M. Wright, Jorge R. Barrio
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Patent number: 8742139Abstract: Phenyliodonium ylide derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are shown for use as precursors in aromatic nucleophilic substitution reactions. The iodonium ylide group is substituted by nucleophiles such as halide ions to provide the corresponding haloaryl derivatives. No-carrier-added [F-18]fluoride ion exclusively substitutes the iodonium ylide moiety in these derivatives and provides high specific activity F-18 labeled fluoro derivatives. Protected L-dopa-6-iodonium ylide derivative have been synthesized as a precursors for the preparation of no-carrier-added 6-[F-18]fluoro-L-dopa. The iodonium ylide group in this L-dopa.derivative is nucleophilically substituted by no-carrier-added [F-18]fluoride ion to provide a [F-18]fluoro intermediates which upon acid hydrolysis yielded 6-[F-18]fluoro-L-dopa.Type: GrantFiled: April 1, 2010Date of Patent: June 3, 2014Assignee: The Regents of The University of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio
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Patent number: 8674101Abstract: Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18]fluoride ion derived from anhydrous [F-18](F/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F-18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.Type: GrantFiled: July 13, 2009Date of Patent: March 18, 2014Assignee: The Regents of the University of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio
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Patent number: 8372380Abstract: Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18F, 123I, 124I, 125I, or 11C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.Type: GrantFiled: March 31, 2008Date of Patent: February 12, 2013Assignee: The Regents of the University of CaliforniaInventors: Jorge R. Barrio, Vladimir Kepe, Gary W. Small, Nagichettiar Satyamurthy
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Publication number: 20120123120Abstract: Phenyliodonium ylide derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are shown for use as precursors in aromatic nucleophilic substitution reactions. The iodonium ylide group is substituted by nucleophiles such as halide ions to provide the corresponding haloaryl derivatives. No-carrier-added [F-18]fluoride ion exclusively substitutes the iodonium ylide moiety in these derivatives and provides high specific activity F-18 labeled fluoro derivatives. Protected L-dopa-6-iodonium ylide derivative have been synthesized as a precursors for the preparation of no-carrier-added 6-[F-18]fluoro-L-dopa. The iodonium ylide group in this L-dopa.derivative is nucleophilically substituted by no-carrier-added [F-18]fluoride ion to provide a [F-18]fluoro intermediates which upon acid hydrolysis yielded 6-[F-18]fluoro-L-dopa.Type: ApplicationFiled: April 1, 2010Publication date: May 17, 2012Applicant: The Regents of the University of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio
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Publication number: 20120107175Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures.Type: ApplicationFiled: August 19, 2009Publication date: May 3, 2012Applicant: The Regents of the Univeristy of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael Van Dam, Sebastian Olma, Dirk Williams, Mark A. Eddings, Clifton Kwang-Fu Shen
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Publication number: 20110178302Abstract: Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18]fluoride ion derived from anhydrous [F-18](F/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F-18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.Type: ApplicationFiled: July 13, 2009Publication date: July 21, 2011Applicant: The Regents of the University of CaliforniaInventors: Nagichettiar Satyamurthy, Jorge R. Barrio
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Publication number: 20100135906Abstract: Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18F, 123I, 124I, 125I, or 11C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.Type: ApplicationFiled: March 31, 2008Publication date: June 3, 2010Inventors: Jorge R. Barrio, Vladimir Kepe, Small W. Gary, Nagichettiar Satyamurthy