Abstract: The trend towards increasing the glazed area in automobiles has reduced the potential locations for mounting cabin lighting. This is especially true for vehicles having large panoramic glazing. Attempts to utilize integrated light sources within the glazing have had mixed results. Embedded LEDs in the laminate tend to be too bright for night driving. Edge feed illumination with light dispersing elements on the glass to date have only been able to provide low intensity levels. Both approaches tend to reduce visibility and aesthetics in the off state. The current invention provides a means and a method to produce a laminate which provides bright cabin lighting without compromising the function of the glazing to serve as a window, by creating a light dispersing layer that is substantially invisible when in the off state and very bright in the on state.

Abstract: The present disclosure relates to a method for treating or ameliorating the effects of a HER2 positive breast cancer in a subject by administration of a combination of tucatinib and an anti-HER2 antibody-drug conjugate (e.g., ado-trastuzumab emtansine or trastuzumab deruxtecan). In some embodiments, the methods provided herein are useful for treating or ameliorating the effects of a brain metastasis in a subject having a HER2 positive breast cancer by administration of a combination of tucatinib and an anti-HER2 antibody-drug conjugate (e.g., ado-trastuzumab emtansine or trastuzumab deruxtecan).

Abstract: The trend towards increasing the glazed area in automobiles has reduced the potential locations for mounting cabin lighting. This is especially true for vehicles having large panoramic glazing. Attempts to utilize integrated light sources within the glazing have had mixed results. Embedded LEDs in the laminate tend to be too bright for night driving. Edge feed illumination with light dispersing elements on the glass to date have only been able to provide low intensity levels. Both approaches tend to reduce visibility and aesthetics in the off state. The current invention provides a means and a method to produce a laminate which provides bright cabin lighting without compromising the function of the glazing to serve as a window, by creating a light dispersing layer that is substantially invisible when in the off state and very bright in the on state.

Abstract: The trend towards increasing the glazed area in automobiles has reduced the potential locations for mounting cabin lighting. This is especially true for vehicles having large panoramic glazing. Attempts to utilize integrated light sources within the glazing have had mixed results. Embedded LEDs in the laminate tend to be too bright for night driving. Edge feed illumination with light dispersing elements on the glass to date have only been able to provide low intensity levels. Both approaches tend to reduce visibility and aesthetics in the off state. The current invention provides a means and a method to produce a laminate which provides bright cabin lighting without compromising the function of the glazing to serve as a window, by creating a light dispersing layer that is substantially invisible when in the off state and very bright in the on state.

Abstract: The trend towards increasing the glazed area in automobiles has reduced the potential locations for mounting cabin lighting. This is especially true for vehicles having large panoramic glazing. Attempts to utilize integrated light sources within the glazing have had mixed results. Embedded LEDs in the laminate tend to be too bright for night driving. Edge feed illumination with light dispersing elements on the glass to date have only been able to provide low intensity levels. Both approaches tend to reduce visibility and aesthetics in the off state. The current invention provides a means and a method to produce a laminate which provides bright cabin lighting without compromising the function of the glazing to serve as a window, by creating a light dispersing layer that is substantially invisible when in the off state and very bright in the on state.

Abstract: Method of producing sintered nickel ferrite powder having steps of mixing the particles of iron oxide and nickel oxide with an alkali metal borate mineralizer, compacting the mixture to produce green compact and heating the compact at temperatures less than about 1400° C. Resulting product which may be in the form of a non-consumable electrode for electrolysis of alumina, exhibits satisfactory mechanical properties and electrical properties with enhanced chemical stability while being produced at significantly lower sintering temperatures than previously employed.