Patents by Inventor Jorge Velarde, Jr.
Jorge Velarde, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170175109Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: ApplicationFiled: March 6, 2017Publication date: June 22, 2017Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, Jr., Steven M. Barnard, Michael Graige
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Patent number: 9587273Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: GrantFiled: May 6, 2016Date of Patent: March 7, 2017Assignee: ILLUMINA, INC.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, Jr., Steven M. Barnard, Michael Graige
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Publication number: 20160251706Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: ApplicationFiled: May 6, 2016Publication date: September 1, 2016Applicant: Illumina, Inc.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, JR., Steven M. BaRNARD, Michael Graige
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Patent number: 9340781Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: GrantFiled: August 18, 2015Date of Patent: May 17, 2016Assignee: ILLUMINA, INC.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, Jr., Steven M. Barnard, Michael Graige
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Patent number: 9139826Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: GrantFiled: November 7, 2014Date of Patent: September 22, 2015Assignee: Illumina, Inc.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, Jr., Steven M. Barnard, Michael Graige
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Publication number: 20150065387Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: ApplicationFiled: November 7, 2014Publication date: March 5, 2015Applicant: Illumina, Inc.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, JR., Steven M. Barnard, Michael Graige
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Patent number: 8916350Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: GrantFiled: October 4, 2013Date of Patent: December 23, 2014Assignee: Illumina, Inc.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, Jr., Steven M. Barnard, Michael Graige
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Publication number: 20140045720Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: ApplicationFiled: October 4, 2013Publication date: February 13, 2014Applicant: Illumina, Inc.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, JR., Steven M. Barnard, Michael Graige
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Patent number: 8568979Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: GrantFiled: August 24, 2007Date of Patent: October 29, 2013Assignee: Illumina, Inc.Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, Jr., Steven M. Bernard, Michael Graige
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Publication number: 20100093550Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.Type: ApplicationFiled: August 24, 2007Publication date: April 15, 2010Inventors: John R. Stuelpnagel, David L. Barker, Jorge Velarde, JR., Steven M. Barnard, Michael Graige
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Patent number: 5919701Abstract: The present invention features compounds and methods for inhibiting propagation of human immunodeficiency virus (HIV). Preferred HIV target sites are identified and oligonucleotides designed to hybridize to a target site are described. The preferred use of the oligonucleotides is as an anti-HIV agent to inhibit HIV propagation in a patient infected with HIV. Other uses of the present invention include detecting the presence of HIV by using the oligonucleotides as detection probes or amplification primers, and measuring the ability of an oligonucleotide to inhibit HIV propagation to evaluate its suitability as an anti-HIV agent for a phenotype of HIV or diagnose the presence of HIV in a patient.Type: GrantFiled: June 2, 1997Date of Patent: July 6, 1999Assignee: Gen-Probe IncorporatedInventors: Todd C. Peterson, Jorge Velarde, Jr.
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Patent number: 5824475Abstract: The invention features a method for assaying the ability of an oligonucleotide to form a hybrid with a target nucleic acid sequence. The featured assay comprises the following steps: (a) contacting a test sample containing a target nucleic acid sequence with an oligonucleotide; (b) treating the test sample with a duplex-altering agent; (c) contacting the treated test sample with a labeled probe under stringent hybridization conditions, wherein the probe can hybridize to non-altered target nucleic acid sequence such that the probe label is protected from subsequent chemical inactivation but the probe cannot hybridize to altered target nucleic acid sequence in a manner which would protect the probe label from subsequent chemical inactivation; and (d) measuring the hybridization of the probe to non-altered target nucleic acid sequence by measuring the amount of protected label.Type: GrantFiled: June 7, 1995Date of Patent: October 20, 1998Assignee: Gen-Probe IncorporatedInventors: Norman C. Nelson, Jorge Velarde, Jr., Daniel L. Kacian
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Patent number: 5629413Abstract: The present invention features compounds and methods for inhibiting propagation of human immunodeficiency virus (HIV). Preferred HIV target sites are identified and oligonucleotides designed to hybridize to a target site are described. The preferred use of the oligonucleotides is as an anti-HIV agent to inhibit HIV propagation in a patient infected with HIV. Other uses of the present invention include detecting the presence of HIV by using the oligonucleotides as detection probes or amplification primers, and measuring the ability of an oligonucleotide to inhibit HIV propagation to evaluate its suitability as an anti-HIV agent for a phenotype of HIV or diagnose the presence of HIV in a patient.Type: GrantFiled: July 19, 1994Date of Patent: May 13, 1997Assignee: Gen-Probe IncorporatedInventors: Todd C. Peterson, Jorge Velarde, Jr.
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Patent number: 5106965Abstract: The present invention relates to DNA and proteins of human adenovirus Type 41 and their use in detection of said virus. More specifically, the present invention relates to the isolation of a 41.4 kd short fiber protein and a 60.6 kd long fiber protein of adenovirus type 41 (Ad41), as well as proteins derived from the Ad41 E3 region, thereby providing virus-derived antigens and active derivatives and parts thereof, useful in the development of diagnostic assays, DNA probes and vaccines for said virus or other related viruses belonging to the human enteric adenovirus family. In addition, the present invention is directed to recombinant DNA molecules containing the human enteric adenovirus Type 41 Tak long fiber protein gene, the Ad41 short fiber protein gene and the Ad41 E3 gene (encoding the Ad41 proteins RL-1 to RL-6) thereby providing a source of recombinant viral components useful in the development of said diagnostic assays, DNA probes and vaccines for human adenoviruses.Type: GrantFiled: April 9, 1990Date of Patent: April 21, 1992Assignee: Research Corporation Technologies, Inc.Inventors: Norman J. Pieniazek, Susan B. Slemenda, Danuta Pieniazek, Jorge Velarde, Jr., Ronald B. Luftig